| Primary information |
|---|
| PRRID | PRRID_1114 |
| Ligand Name | Pam3CysK |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB.  |
| Name of receptor | Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | TRIF mutant (C57BL/6J-Ticam1Lps2) mice |
| Localization | bone marrow-derived macrophage (BMDM) culture |
| Domain | Toll/IL-1R (TIR) domain |
| Sequence of Receptor | Q9QUN7.fasta |
| Swiss prot ID | Q9QUN7 |
| Length Of Receptor | 784 |
| Function | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. |
| Assay used | Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations |
| PMID | 24019532 |
| Year of Publication | 2013 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1114 |
| Ligand Name | Pam3CysK |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB.  |
| Name of receptor | Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | TRIF mutant (C57BL/6J-Ticam1Lps2) mice |
| Localization | bone marrow-derived macrophage (BMDM) culture |
| Domain | Toll/IL-1R (TIR) domain |
| Sequence of Receptor | Q9QUN7.fasta |
| Swiss prot ID | Q9QUN7 |
| Length Of Receptor | 784 |
| Function | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. |
| Assay used | Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations |
| PMID | 24019532 |
| Year of Publication | 2013 |
| Pubchem assay | Pubchem_assay |