Detailed description page of PRRDB2.0

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PRRID_1042 details
Primary information
PRRIDPRRID_1042
Ligand NameFlagellin
SourceBacteria
Sequence of ligandMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR
Length495
TypeProtein
OccurenceNatural
Role of Ligandtriggers immune responses
Name of receptorToll-like receptor 5 (TLR5)
Type of receptorToll-like receptor (TLR)
Source TRIF mutant (C57BL/6J-Ticam1Lps2) mice
Localizationbone marrow-derived macrophage (BMDM) culture
Domain Toll/IL-1R (TIR) domain
Sequence of ReceptorQ9JLF7.fasta
Swiss prot IDQ9JLF7
Length Of Receptor859
FunctionIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.
Assay usedQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations
PMID24019532
Year of Publication2013
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1042
Ligand NameFlagellin
SourceBacteria
Sequence of ligandMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR
Length495
TypeProtein
OccurenceNatural
Role of Ligandtriggers immune responses
Name of receptorToll-like receptor 5 (TLR5)
Type of receptorToll-like receptor (TLR)
Source TRIF mutant (C57BL/6J-Ticam1Lps2) mice
Localizationbone marrow-derived macrophage (BMDM) culture
Domain Toll/IL-1R (TIR) domain
Sequence of ReceptorQ9JLF7.fasta
Swiss prot IDQ9JLF7
Length Of Receptor859
FunctionIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.
Assay usedQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations
PMID24019532
Year of Publication2013
Pubchem assayPubchem_assay