Detailed description page of PRRDB2.0

This page displays user query in tabular form.

PRRID_1088 details
Primary information
PRRIDPRRID_1088
Ligand NameLipopolysaccharide (LPS)
SourceGram negative Bacteria (Bacteria)
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of Ligandelicit innate immune response
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source TRIF mutant (C57BL/6J-Ticam1Lps2) mice
Localizationbone marrow-derived macrophage (BMDM) culture
Domain Toll/IL-1R (TIR) domain
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations
PMID24019532
Year of Publication2013
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1088
Ligand NameLipopolysaccharide (LPS)
SourceGram negative Bacteria (Bacteria)
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of Ligandelicit innate immune response
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source TRIF mutant (C57BL/6J-Ticam1Lps2) mice
Localizationbone marrow-derived macrophage (BMDM) culture
Domain Toll/IL-1R (TIR) domain
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations
PMID24019532
Year of Publication2013
Pubchem assayPubchem_assay