Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1424	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay
PRRID_1424	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay
PRRID_1425	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1425	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1426	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	cell surface	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1426	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	cell surface	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1427	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1427	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1428	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1428	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1429	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1429	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1430	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1430	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1431	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	European and African Children	MyD88, TRIF	MyD88, TRIF	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24743542	2014	Pubchem_assay
PRRID_1431	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	European and African Children	MyD88, TRIF	MyD88, TRIF	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24743542	2014	Pubchem_assay
PRRID_1432	Lipopolysaccharide (LPS) Click for more detail	E. coli K12(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induced significant up-regulation of IL-1b and IL-8	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1432	Lipopolysaccharide (LPS) Click for more detail	E. coli K12(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induced significant up-regulation of IL-1b and IL-8	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1433	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli O26:B6 strain (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	promote lupus progression	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	extracellular domain (ECD)	Q9QUK6.fasta	Q9QUK6	835	surface-expressed TLR4 is crucial to promote the lupus progression	ELISA	24719374	2014	Pubchem_assay
PRRID_1433	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli O26:B6 strain (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	promote lupus progression	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	extracellular domain (ECD)	Q9QUK6.fasta	Q9QUK6	835	surface-expressed TLR4 is crucial to promote the lupus progression	ELISA	24719374	2014	Pubchem_assay
PRRID_1434	Lipopolysaccharide (LPS) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARŒ±), a nuclear transcription factor	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Lewis rats	monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	NA	NA	NA	TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases.	western blotting	24717912	2014	NA
PRRID_1434	Lipopolysaccharide (LPS) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARŒ±), a nuclear transcription factor	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Lewis rats	monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	NA	NA	NA	TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases.	western blotting	24717912	2014	NA
PRRID_1435	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Soluble CD14 (sCD14)	Pattern recognition receptor (PRR)	Mice	in bodily fluids such as tears (0.5	TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway	NA	NA	NA	signal an immune response through Toll- like receptor 4 (TLR4)	NA	24703105	2014	NA
PRRID_1435	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Soluble CD14 (sCD14)	Pattern recognition receptor (PRR)	Mice	in bodily fluids such as tears (0.5	TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway	NA	NA	NA	signal an immune response through Toll- like receptor 4 (TLR4)	NA	24703105	2014	NA
PRRID_1441	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	Histological analyses, Real-time PCR analysis, Western blotting	24815695	2014	Pubchem_assay
PRRID_1441	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	Histological analyses, Real-time PCR analysis, Western blotting	24815695	2014	Pubchem_assay
PRRID_1446	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1446	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1447	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	keratinocytes and mouse skin	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1447	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	keratinocytes and mouse skin	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1448	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	keratinocytes and mouse skin	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1448	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	keratinocytes and mouse skin	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1449	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1449	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1450	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1450	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1451	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1451	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1452	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1452	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1453	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1453	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1454	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1454	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1455	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1455	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1456	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1456	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1463	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	JNKBP1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1463	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	JNKBP1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1467	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1467	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1468	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1468	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1469	D-mannose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1469	D-mannose Click for more detail	Bacteria	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1470	N-Acetyl-D-mannosamine Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1470	N-Acetyl-D-mannosamine Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	NA	ERGIC-53	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1471	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	VIP36	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1471	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	VIP36	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	24796868	2014	NA
PRRID_1472	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	DUOX2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1472	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	DUOX2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1473	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	FRMPD2	NOD-like receptor (NLR)	NA	stabilizes NOD2, required for NF-kB signalling	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1473	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	FRMPD2	NOD-like receptor (NLR)	NA	stabilizes NOD2, required for NF-kB signalling	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1479	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	purification of recombinant proteins as a protein tag	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1479	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	purification of recombinant proteins as a protein tag	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1480	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	induce dendritic cell activation and the production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	peritoneal macrophages	transmembrane	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1480	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	induce dendritic cell activation and the production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	peritoneal macrophages	transmembrane	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1481	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	responsible for the uptake and efficient catabolism of maltodextrins	Mannose Receptor (CD206)	Mannose receptor (MR)	Mice	peritoneal macrophages	cell surface	Q61830.fasta	Q61830	1456	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1481	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	responsible for the uptake and efficient catabolism of maltodextrins	Mannose Receptor (CD206)	Mannose receptor (MR)	Mice	peritoneal macrophages	cell surface	Q61830.fasta	Q61830	1456	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1484	meso-lanthionine tripeptide Click for more detail	PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria)	NA	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	most adult tissues	intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1484	meso-lanthionine tripeptide Click for more detail	PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria)	NA	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	most adult tissues	intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1485	meso-lanthionine tripeptide Click for more detail	PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria)	NA	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1485	meso-lanthionine tripeptide Click for more detail	PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria)	NA	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1487	monomeric flagellin Click for more detail	Bacteria	MAQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKNGSMKIQVGANDNQTITIDLKQIDAKTLGLDGFSVKNNDTVTTSAPVTAFGATTTNNIKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKATTITSGGTPVQIDNTAGSATANLGAVSLVKLQDSKGNDTDTYALKDTNGNLYAADVNETTGAVSVKTITYTDSSGAASSPTAVKLGGDDGKTEVVDIDGKTYDSADLNGGNLQTGLTAGGEALTAVANGKTTDPLKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLLQG	498	Pattern-associated molecular patterns (PAMPs)	Natural	It directly interac with TLR 5 and induces immune response	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1487	monomeric flagellin Click for more detail	Bacteria	MAQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKNGSMKIQVGANDNQTITIDLKQIDAKTLGLDGFSVKNNDTVTTSAPVTAFGATTTNNIKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKATTITSGGTPVQIDNTAGSATANLGAVSLVKLQDSKGNDTDTYALKDTNGNLYAADVNETTGAVSVKTITYTDSSGAASSPTAVKLGGDDGKTEVVDIDGKTYDSADLNGGNLQTGLTAGGEALTAVANGKTTDPLKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLLQG	498	Pattern-associated molecular patterns (PAMPs)	Natural	It directly interac with TLR 5 and induces immune response	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1495	muramyl tripeptide Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Mice	intraepithelial T lymphocytes	intracellular receptors	Q9JLF7.fasta	Q9JLF7	859	recognises peptidoglycan of bacterial cell wall	NA	24779390	2014	Pubchem_assay
PRRID_1495	muramyl tripeptide Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Mice	intraepithelial T lymphocytes	intracellular receptors	Q9JLF7.fasta	Q9JLF7	859	recognises peptidoglycan of bacterial cell wall	NA	24779390	2014	Pubchem_assay
PRRID_1496	muramyl tripeptide Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Human	intraepithelial T lymphocytes	intracellular receptors	Q96PD5.fasta	Q96PD5	576	recognises peptidoglycan of bacterial cell wall	NA	24779390	2014	Pubchem_assay
PRRID_1496	muramyl tripeptide Click for more detail	Mycobacteria (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	PGLYRP-2	Peptidoglycan Recognition Receptor (PGRPs)	Human	intraepithelial T lymphocytes	intracellular receptors	Q96PD5.fasta	Q96PD5	576	recognises peptidoglycan of bacterial cell wall	NA	24779390	2014	Pubchem_assay
PRRID_1497	N-glycolylated muramic acid Click for more detail	Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Carbohydrate	Natural	activates NOD2	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Mice	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1497	N-glycolylated muramic acid Click for more detail	Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Carbohydrate	Natural	activates NOD2	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Mice	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1498	N-glycolylated muramic acid Click for more detail	Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Carbohydrate	Natural	activates NOD2	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Human	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q9HC29.fasta	Q9HC29	1040	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1498	N-glycolylated muramic acid Click for more detail	Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Carbohydrate	Natural	activates NOD2	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Human	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q9HC29.fasta	Q9HC29	1040	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1499	N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1499	N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1504	NACHT Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CARD8	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1504	NACHT Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CARD8	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1505	NACHT Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1505	NACHT Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA

previous 1 2...7 8 91011 12 13...35 36 next