Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1665Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)Plasmacytoid dendritic cells (pDCs) within endosomal compartmentsintracellular receptorsP58681.fastaP586811050important role in the immune response to viral infectionflow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA248142382014Pubchem_assay
PRRID_1665Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Mice (Murine)Plasmacytoid dendritic cells (pDCs) within endosomal compartmentsintracellular receptorsP58681.fastaP586811050important role in the immune response to viral infectionflow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA248142382014Pubchem_assay
PRRID_1666Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)Plasmacytoid dendritic cells (pDCs) within endosomal compartmentsintracellular receptorsQ9NR96.fastaQ9NR961032important role in the immune response to viral infectionflow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA248142382014Pubchem_assay
PRRID_1666Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Mice (Murine)Plasmacytoid dendritic cells (pDCs) within endosomal compartmentsintracellular receptorsQ9NR96.fastaQ9NR961032important role in the immune response to viral infectionflow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA248142382014Pubchem_assay
PRRID_1667Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytescell compartmentQ9NR96.fastaQ9NR961032Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1667Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytescell compartmentQ9NR96.fastaQ9NR961032Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1668Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytescell compartmentQ9NR96.fastaQ9NR961032Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1668Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytescell compartmentQ9NR96.fastaQ9NR961032Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1669Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalact as adjuvants in vaccination strategiesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)C57BL/6 MicepDCs, macrophagesCell Compartment/Intracellular (phagosomal compartment)Q9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA248016282014Pubchem_assay
PRRID_1669Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturalact as adjuvants in vaccination strategiesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)C57BL/6 MicepDCs, macrophagesCell Compartment/Intracellular (phagosomal compartment)Q9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA248016282014Pubchem_assay
PRRID_1670Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Male BALB/c miceMyeloid-derived suppressor cells (MDSCs)Intracellular receptorsQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunityFunctional assay247485122014Pubchem_assay
PRRID_1670Unmethylated CpG DNA

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BacteriaNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Male BALB/c miceMyeloid-derived suppressor cells (MDSCs)Intracellular receptorsQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunityFunctional assay247485122014Pubchem_assay
PRRID_1673Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagesCell Surface (Exogenous)Q6R5P0.fastaQ6R5P0926TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA248300242014Pubchem_assay
PRRID_1673Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagesCell Surface (Exogenous)Q6R5P0.fastaQ6R5P0926TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA248300242014Pubchem_assay
PRRID_1676Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1676Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1677Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1677Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalactivates macrophages via TLR2.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANATLR2 cooperates with TLR6 and CD14 in response to zymosanNA248300242014NA
PRRID_1678Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmast cellscell surfaceO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesReal-time PCR248186342014Pubchem_assay
PRRID_1678Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmast cellscell surfaceO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responsesReal-time PCR248186342014Pubchem_assay
PRRID_1689b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPxbGRPGastrin-releasing peptide receptor (GRP)Plutella xylostellaNANANANANANANA256176162015NA
PRRID_1689b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPxbGRPGastrin-releasing peptide receptor (GRP)Plutella xylostellaNANANANANANANA256176162015NA
PRRID_1698Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantBrain angiogenesis inhibitor 1 (BAI1)*, adhesion G-protein coupled receptor 1Scavenger receptor (SR)NANANANANANAELMO–Dock180–Rac1 moduleNA266831442015NA
PRRID_1698Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantBrain angiogenesis inhibitor 1 (BAI1)*, adhesion G-protein coupled receptor 1Scavenger receptor (SR)NANANANANANAELMO–Dock180–Rac1 moduleNA266831442015NA
PRRID_1699Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantLvLGBPPattern recognition receptor (PRR)Litopenaeus vannameiHemocytesNANANANAcause degranulation, and activate the proPO system that subsequently leads to an increase in PO activity, indicating the activation of innate immunity.ELISA265223392015NA
PRRID_1699Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantLvLGBPPattern recognition receptor (PRR)Litopenaeus vannameiHemocytesNANANANAcause degranulation, and activate the proPO system that subsequently leads to an increase in PO activity, indicating the activation of innate immunity.ELISA265223392015NA
PRRID_1700NA

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Gram negative Bacteria (Bacteria)NANANANaturalImmunostimulantHlCLecC type Lectin (CTL/CLR)Haemaphysalis longicornis ticks midgut and ovaryTriple carbohydrate recognition domainsNANANAKey role in innate immunity.NA267243792015NA
PRRID_1700NA

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Gram negative Bacteria (Bacteria)NANANANaturalImmunostimulantHlCLecC type Lectin (CTL/CLR)Haemaphysalis longicornis ticks midgut and ovaryTriple carbohydrate recognition domainsNANANAKey role in innate immunity.NA267243792015NA
PRRID_1702Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_1702Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_1703Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellsLRRO00206.fastaO00206839It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_1703Surface Layer Proteins (SLPs)

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Clostridium difficile(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalThe binding induces the production of IL-23 via MyD-88 signalling pathway.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanDendritic cellsLRRO00206.fastaO00206839It has the role in the inflammation.ELISA256269052015Pubchem_assay
PRRID_170619 kDa lipoprotein

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Mycobacterium tuberculosis (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159NANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduces apoptosis and inhibits IFN- induced expression of several immune function genesNA267757992016NA
PRRID_170619 kDa lipoprotein

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Mycobacterium tuberculosis (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159NANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduces apoptosis and inhibits IFN- induced expression of several immune function genesNA267757992016NA
PRRID_1716b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Fenneropenaeus merguiensisHepatopancreasNANANANAActivate NF-KBELISA274319302016NA
PRRID_1716b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Fenneropenaeus merguiensisHepatopancreasNANANANAActivate NF-KBELISA274319302016NA
PRRID_1717Bacterial 23S ribosomal RNA

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BacteriaGGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA2905Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5N8.fastaQ6R5N8991Activate NF-KBNA277566042016Pubchem_assay
PRRID_1717Bacterial 23S ribosomal RNA

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BacteriaGGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA2905Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5N8.fastaQ6R5N8991Activate NF-KBNA277566042016Pubchem_assay
PRRID_1722cathepsin cysteine

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Schistosoma mansoni, Fasciola hepatica (Bacteria)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1722cathepsin cysteine

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Schistosoma mansoni, Fasciola hepatica (Bacteria)MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN340Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceNANAQ99MB1.fastaQ99MB1905Dampen TRIF signaling by degradation of TLR3ÔòªNA271202222016Pubchem_assay
PRRID_1724CpG-ODN

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BacteriaNANANucleic AcidSyntheticImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB3DJW3.fastaB3DJW31057induce IFN expressionNA277214562016Pubchem_assay
PRRID_1724CpG-ODN

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BacteriaNANANucleic AcidSyntheticImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainB3DJW3.fastaB3DJW31057induce IFN expressionNA277214562016Pubchem_assay
PRRID_1725CpG-ODN

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BacteriaNANANucleic AcidSyntheticImmunostimulantToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QMN8.fastaF1QMN8989induce IFN expressionNA277214562016Pubchem_assay
PRRID_1725CpG-ODN

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BacteriaNANANucleic AcidSyntheticImmunostimulantToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QMN8.fastaF1QMN8989induce IFN expressionNA277214562016Pubchem_assay
PRRID_1737Flagellin

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Salmonella (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1737Flagellin

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Salmonella (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1738Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9JLF7.fastaQ9JLF7859nuclear factor NF- κB mobilization and the stimulation and secretion of cytokines.NA277566042016Pubchem_assay
PRRID_1738Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9JLF7.fastaQ9JLF7859nuclear factor NF- κB mobilization and the stimulation and secretion of cytokines.NA277566042016Pubchem_assay
PRRID_1739Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5a/b (TLR5a/b)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainNANANAinduce IFN expressionNA277214562016NA
PRRID_1739Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalImmunostimulantToll-like receptor 5a/b (TLR5a/b)Toll-like receptor (TLR)Zebrafishendosomes and lysosomes.extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainNANANAinduce IFN expressionNA277214562016NA
PRRID_1741Flavolipin

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Flavobacterium meningosepticum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1741Flavolipin

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Flavobacterium meningosepticum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1745Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1745Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1748GroEL

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Pseudomonas aeruginosa (Bacteria)DPTKVTRTALQNAASIAGLMITTEAMVAEAPKKDEPAMPPGGGMGGMGGMDF52GlycoproteinNaturalBacterial infection and immunostimulantPTX3Peptidoglycan Recognition Receptor (PGRPs)HumanMonocytesNAP26022.fastaP26022381NANA280312622016Pubchem_assay
PRRID_1748GroEL

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Pseudomonas aeruginosa (Bacteria)DPTKVTRTALQNAASIAGLMITTEAMVAEAPKKDEPAMPPGGGMGGMGGMDF52GlycoproteinNaturalBacterial infection and immunostimulantPTX3Peptidoglycan Recognition Receptor (PGRPs)HumanMonocytesNAP26022.fastaP26022381NANA280312622016Pubchem_assay
PRRID_1750HDM

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Schistosoma mansoni, Fasciola hepatica (Bacteria)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1750HDM

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Schistosoma mansoni, Fasciola hepatica (Bacteria)RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN70Pattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835Alter the response of B cells (‚ÜëIgGÔõú)NA271202222016Pubchem_assay
PRRID_1753High-mannose glycans

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1753High-mannose glycans

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1757Lipopeptides

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1757Lipopeptides

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1764Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1764Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1766Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Fenneropenaeus merguiensisHepatopancreasNANANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaELISA274319302016NA
PRRID_1766Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Fenneropenaeus merguiensisHepatopancreasNANANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaELISA274319302016NA
PRRID_1767Lipopolysaccharide (LPS)

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A.hydrophilla(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCause bacterial infection, immunostimulantPcFBN1FREPProcambarus clarkiihepatopancreas and hemocyteFBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.NANANAtrigger complement system via the lectin-dependent pathway.Ligand binding assay274172292016NA
PRRID_1767Lipopolysaccharide (LPS)

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A.hydrophilla(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalCause bacterial infection, immunostimulantPcFBN1FREPProcambarus clarkiihepatopancreas and hemocyteFBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.NANANAtrigger complement system via the lectin-dependent pathway.Ligand binding assay274172292016NA
PRRID_1768Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1768Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1770Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAC1qPattern recognition receptor (PRR)NANANANANANANANA260026402016NA
PRRID_1770Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAC1qPattern recognition receptor (PRR)NANANANANANANANA260026402016NA
PRRID_1771Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNACgC1qDC-1Pattern recognition receptor (PRR)NANANANANANANANA260026402016NA
PRRID_1771Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNACgC1qDC-1Pattern recognition receptor (PRR)NANANANANANANANA260026402016NA
PRRID_1772Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCD300b-Toll like receptor4 (TLR4) complexPattern recognition receptor (PRR)HumanNANANANANAled to the recruitment and activation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphos- phate 3-kinase (PI3K).NA272612762016NA
PRRID_1772Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCD300b-Toll like receptor4 (TLR4) complexPattern recognition receptor (PRR)HumanNANANANANAled to the recruitment and activation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphos- phate 3-kinase (PI3K).NA272612762016NA
PRRID_1774Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantEcToll-like receptor (TLR1b)Toll-like receptor (TLR)Zebrafishspleen and head kidneyleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1774Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantEcToll-like receptor (TLR1b)Toll-like receptor (TLR)Zebrafishspleen and head kidneyleucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.NANANAActivate NF-KbNA270372192016NA
PRRID_1775Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCgSiglec-1Pattern recognition receptor (PRR)Crassostrea gigasNACRD or C1q domainNANANAact as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.NA270326022016NA
PRRID_1775Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantCgSiglec-1Pattern recognition receptor (PRR)Crassostrea gigasNACRD or C1q domainNANANAact as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.NA270326022016NA
PRRID_1776Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantOfGal-1 galectin-1Oplegnathus fasciatus gills, head kidney, and liver.NANANANA OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream.NA267927592016NA
PRRID_1776Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantOfGal-1 galectin-1Oplegnathus fasciatus gills, head kidney, and liver.NANANANA OfGal-1 can recognize a wide range of microbes and is a vital pattern recognition receptor in the innate immune system of rock bream.NA267927592016NA
PRRID_1777Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduces TNF-alpha and IL-6NA267757992016NA
PRRID_1777Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduces TNF-alpha and IL-6NA267757992016NA
PRRID_1778Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAInduces TNF-alpha and IL-6NA267757992016NA
PRRID_1778Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAInduces TNF-alpha and IL-6NA267757992016NA
PRRID_1779Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1779Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1780Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1780Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1781Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1781Glucan

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNACfLRRop-3Leucine rich repeats (LRR)NANANANANANANANA268264252016NA
PRRID_1786Lipopolysaccharide (LPS)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1786Lipopolysaccharide (LPS)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1787Peptidoglycan (PGN)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1787Peptidoglycan (PGN)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1788Mannan

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1788Mannan

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1789Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1789Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA