| Primary information |
|---|
| PRRID | PRRID_1434 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | cell wall of Gram-positive bacteria(Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Natural |
| Role of Ligand | functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARα), a nuclear transcription factor |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Lewis rats |
| Localization | monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells |
| Domain | Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases. |
| Assay used | western blotting |
| PMID | 24717912 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1434 |
| Ligand Name | Lipopolysaccharide (LPS) |
| Source | cell wall of Gram-positive bacteria(Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Lipopolysaccharide (LPS) |
| Occurence | Natural |
| Role of Ligand | functions as an antagonist of peroxisome proliferator-activated receptor alpha (PPARα), a nuclear transcription factor |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Lewis rats |
| Localization | monocytes/macrophages, and nonprofessional immune cells, such as epithelial cells |
| Domain | Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR4 plays a pivotal role in host defense, and inappropriate TLR4 activation can result in the acceleration of inflammatory and autoimmune diseases. |
| Assay used | western blotting |
| PMID | 24717912 |
| Year of Publication | 2014 |
| Pubchem assay | NA |