| Primary information |
|---|
| PRRID | PRRID_1499 |
| Ligand Name | N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB. |
| Name of receptor | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. |
| Assay used | ELISA and Immunofluoroscence assay |
| PMID | 24830384 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1499 |
| Ligand Name | N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB. |
| Name of receptor | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. |
| Assay used | ELISA and Immunofluoroscence assay |
| PMID | 24830384 |
| Year of Publication | 2014 |
| Pubchem assay | NA |