Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1446	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1446	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1447	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	keratinocytes and mouse skin	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1447	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	keratinocytes and mouse skin	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1448	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	keratinocytes and mouse skin	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1448	Lipoteichoic Acid (LTA) Click for more detail	Staphylococcus epidermidis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	keratinocytes and mouse skin	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1449	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1449	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUN7.fasta	Q9QUN7	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1450	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1450	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O60603.fasta	O60603	784	important for inflammation in the skin following injury	NA	24784586	2014	Pubchem_assay
PRRID_1451	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1451	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1452	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1452	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1453	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1453	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1454	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1454	Lipoteichoic Acid (LTA) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1455	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1455	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1456	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1456	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1458	low molecular weight molecules of the imidazoquinoline family Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1458	low molecular weight molecules of the imidazoquinoline family Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1459	low molecular weight molecules of the imidazoquinoline family Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1459	low molecular weight molecules of the imidazoquinoline family Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1460	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It activates the innate immune system through Toll-like receptor 7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1460	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It activates the innate immune system through Toll-like receptor 7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1461	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	It activates the innate immune system through Toll-like receptor 7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1461	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	It activates the innate immune system through Toll-like receptor 7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1462	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1462	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1474	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1475	macrophage-activating lipopeptide-2 (MALP-2) Click for more detail	Mycoplasma fementans (Bacteria)	NA	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1476	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1477	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771854	2014	NA
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1478	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1479	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	purification of recombinant proteins as a protein tag	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1479	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	purification of recombinant proteins as a protein tag	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1480	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	induce dendritic cell activation and the production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	peritoneal macrophages	transmembrane	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1480	Maltose-binding protein (MBP) Click for more detail	E. coli(Bacteria)	MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK	396	Pattern-associated molecular patterns (PAMPs)	Natural	induce dendritic cell activation and the production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	peritoneal macrophages	transmembrane	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR	24825603	2014	Pubchem_assay
PRRID_1488	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1488	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24830024	2014	Pubchem_assay
PRRID_1490	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1490	mRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1499	N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1499	N-palmitoyl-S-[2,3-bis(palmitoyloxy)-propyl]-(R)-cysteinyl-(lysyl)3-lysine (PAM3CSK4) Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1502	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	NA	Real-time PCR	24736205	2014	NA
PRRID_1502	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	NA	Real-time PCR	24736205	2014	NA
PRRID_1503	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5X405.fasta	B5X405	962	NA	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1503	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5X405.fasta	B5X405	962	NA	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1513	naloxone Click for more detail	synthetic alkaloids (others)	O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	spinal microglia, macrophage and astrocytes	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24824631	2014	Pubchem_assay
PRRID_1513	naloxone Click for more detail	synthetic alkaloids (others)	O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	spinal microglia, macrophage and astrocytes	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24824631	2014	Pubchem_assay
PRRID_1514	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1514	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1515	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1515	Non-methylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24754320	2014	Pubchem_assay
PRRID_1516	non-methylated cytosine‚Äìguanine dinucleotide (Cg) motifs Click for more detail	Bacterial, viral and mitochondrial Dna	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with metastatic colorectal carcinoma (CRC)	plasmacytoid dendritic cells (pDC) and B cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24816725	2014	Pubchem_assay
PRRID_1516	non-methylated cytosine‚Äìguanine dinucleotide (Cg) motifs Click for more detail	Bacterial, viral and mitochondrial Dna	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human patients with metastatic colorectal carcinoma (CRC)	plasmacytoid dendritic cells (pDC) and B cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	24816725	2014	Pubchem_assay
PRRID_1517	ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1517	ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1518	oxidized lipids Click for more detail	Gram-negative bacteria	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1518	oxidized lipids Click for more detail	Gram-negative bacteria	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1519	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of cancer	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1519	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of cancer	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1520	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of cancer	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1520	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of cancer	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1521	Pam3 Click for more detail	Bacteria	NA	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	European and African Children	NA	MyD88	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	24743542	2014	NA
PRRID_1521	Pam3 Click for more detail	Bacteria	NA	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	European and African Children	NA	MyD88	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	24743542	2014	NA
PRRID_1522	Pam3CSK3 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	Real-time PCR	24736205	2014	NA
PRRID_1522	Pam3CSK3 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	Real-time PCR	24736205	2014	NA
PRRID_1523	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1523	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1524	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1524	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1525	Pam3CSK4 Click for more detail	Gram-positive and negative bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	mast cells	cytoplasmic domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	Real-time PCR	24818634	2014	NA
PRRID_1525	Pam3CSK4 Click for more detail	Gram-positive and negative bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	mast cells	cytoplasmic domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	Real-time PCR	24818634	2014	NA
PRRID_1526	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine.	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	ELISA	24799523	2014	NA
PRRID_1526	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine.	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6	ELISA	24799523	2014	NA
PRRID_1527	Pam3CSK4 Click for more detail	Salmonella typhimurium(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1527	Pam3CSK4 Click for more detail	Salmonella typhimurium(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1528	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	induce apoptosis in monocytes	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	bone marrow stromal cells (BMSCs)	cell surface	NA	NA	NA	TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents.	Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay	24794258	2014	NA
PRRID_1528	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	induce apoptosis in monocytes	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	bone marrow stromal cells (BMSCs)	cell surface	NA	NA	NA	TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents.	Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay	24794258	2014	NA
PRRID_1529	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1529	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1530	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1530	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771854	2014	Pubchem_assay
PRRID_1531	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	NA
PRRID_1531	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	cell surface	NA	NA	NA	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	NA
PRRID_1532	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	NA
PRRID_1532	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipoprotein	Synthetic	triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-Œ∫B.	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages	cell surface	NA	NA	NA	plays a fundamental role in pathogen recognition and activation of innate immunity	ELISA	24771328	2014	NA
PRRID_1533	Pam3CSK4 + Ara-C Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells.	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines.	ELISA	24799523	2014	NA
PRRID_1533	Pam3CSK4 + Ara-C Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells.	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines.	ELISA	24799523	2014	NA

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