| Primary information |
|---|
| PRRID | PRRID_1528 |
| Ligand Name | Pam3CSK4 |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipopeptides |
| Occurence | Synthetic |
| Role of Ligand | induce apoptosis in monocytes |
| Name of receptor | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | bone marrow stromal cells (BMSCs) |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents. |
| Assay used | Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay |
| PMID | 24794258 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1528 |
| Ligand Name | Pam3CSK4 |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipopeptides |
| Occurence | Synthetic |
| Role of Ligand | induce apoptosis in monocytes |
| Name of receptor | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | bone marrow stromal cells (BMSCs) |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR1/2 triggering may be of therapeutic use to decrease cellular resistance to the cytotoxic action of chemotherapeutic agents. |
| Assay used | Fluorometric Adhesion Assay, Drug Cytotoxicity Assay, Apoptosis Assay |
| PMID | 24794258 |
| Year of Publication | 2014 |
| Pubchem assay | NA |