Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0229Seeligeriolysin O ((rLSO483)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0229Seeligeriolysin O ((rLSO483)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0230Seeligeriolysin O (rLSO530)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUN7.fastaQ9QUN7784This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0230Seeligeriolysin O (rLSO530)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUN7.fastaQ9QUN7784This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0231Seeligeriolysin O (rLSO530)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0231Seeligeriolysin O (rLSO530)

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Listeria seeligeri (Bacteria)MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ530ProteinNaturalIt induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835This leads to the inflammatory response.Transfection and nuclear factor j-B reporter assay162916602005Pubchem Assay
PRRID_0247MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (“Ribi” adjuvant))

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lipid A mimetic (others)CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONALipidSyntheticImmunostimulantToll-like receptor 4+unknownToll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835NANA171856032006Pubchem Assay
PRRID_0247MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (“Ribi” adjuvant))

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lipid A mimetic (others)CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)ONALipidSyntheticImmunostimulantToll-like receptor 4+unknownToll-like receptor (TLR)MiceNANAQ9QUK6.fastaQ9QUK6835NANA171856032006Pubchem Assay
PRRID_0248Poly (I:C)-LANAC

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticAdjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSpleen and lung cellsNAQ99MB1.fastaQ99MB1905TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.ELISA167513772006Pubchem Assay
PRRID_0248Poly (I:C)-LANAC

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticAdjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSpleen and lung cellsNAQ99MB1.fastaQ99MB1905TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.ELISA167513772006Pubchem Assay
PRRID_0251dipalmitoylated proteins

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NANANAProteinNaturaltriggers immune responsesToll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)NANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.ELISA173531992007NA
PRRID_0251dipalmitoylated proteins

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NANANAProteinNaturaltriggers immune responsesToll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)NANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.ELISA173531992007NA
PRRID_0252dsDNA

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Adenovirus(virus)NANANucleic AcidNaturalAdenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MicePlasmacytoid dendritic cellsNAQ9NR96.fastaQ9NR961032This leads to the inflammatory response.ELISA172296892007Pubchem Assay
PRRID_0252dsDNA

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Adenovirus(virus)NANANucleic AcidNaturalAdenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MicePlasmacytoid dendritic cellsNAQ9NR96.fastaQ9NR961032This leads to the inflammatory response.ELISA172296892007Pubchem Assay
PRRID_0254Lipopolysaccharide (LPS)

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enterobacterial bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0254Lipopolysaccharide (LPS)

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enterobacterial bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0255Lipopolysaccharide (LPS)

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E.coli strain O111:B4(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0255Lipopolysaccharide (LPS)

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E.coli strain O111:B4(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduces a strong response from normal animal immune systemsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA173531992007Pubchem Assay
PRRID_0257Lipoprotein

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Gram-negative and Gram-positive bacteriaNANALipoproteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUN7.fastaQ9QUN7784plays a fundamental role in pathogen recognition and activation of innate immunityELISA173531992007Pubchem Assay
PRRID_0257Lipoprotein

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Gram-negative and Gram-positive bacteriaNANALipoproteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)Q9QUN7.fastaQ9QUN7784plays a fundamental role in pathogen recognition and activation of innate immunityELISA173531992007Pubchem Assay
PRRID_0262Pneumocystis carinii

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FungiNANAOthersNaturalImmunostimulantDectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ6QLQ4.fastaQ6QLQ4244cytokine production NA171599822007Pubchem Assay
PRRID_0262Pneumocystis carinii

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FungiNANAOthersNaturalImmunostimulantDectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ6QLQ4.fastaQ6QLQ4244cytokine production NA171599822007Pubchem Assay
PRRID_0264Tripalmitoylated proteins

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NANANACarbohydrateNaturaltriggers immune responsesToll-like receptor 2 (TLR2)/Toll-like receptor (TLR1Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)NANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.ELISA173531992007NA
PRRID_0264Tripalmitoylated proteins

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NANANACarbohydrateNaturaltriggers immune responsesToll-like receptor 2 (TLR2)/Toll-like receptor (TLR1Toll-like receptor (TLR)MicePeripheral blood mononuclear cells (PBMC)cytoplasmic leucine rich repeat (LRR)NANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.ELISA173531992007NA
PRRID_02673M002 (CL075)

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NACCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58682.fastaP586821032It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_02673M002 (CL075)

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NACCCC1=NC2=C(S1)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58682.fastaP586821032It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0270Acute-phase serum amyloid A (SAA)

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Human (others)MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY122ProteinNaturalTLR2 responded to SAA with potent activation of NF-κB, moreover it increased phosphorylation of MAP kinases and accelerated IκBα degradation.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesEctodomainQ9QUN7.fastaQ9QUN7784It is resoonsible for the immuno-inflammation in the host cell.Solid-phase binding assay and NF-κB luciferase report assay185663662008Pubchem Assay
PRRID_0270Acute-phase serum amyloid A (SAA)

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Human (others)MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY122ProteinNaturalTLR2 responded to SAA with potent activation of NF-κB, moreover it increased phosphorylation of MAP kinases and accelerated IκBα degradation.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophagesEctodomainQ9QUN7.fastaQ9QUN7784It is resoonsible for the immuno-inflammation in the host cell.Solid-phase binding assay and NF-κB luciferase report assay185663662008Pubchem Assay
PRRID_0272Aminoalkyl Glucosaminide Phosphate (AGP)

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NANANALipidSyntheticAGPs boost the innate immune response to infection with F. novicida.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahges and Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It provides Protectection to Mice from Pneumonic Tularemia.ELISA184907592008Pubchem Assay
PRRID_0272Aminoalkyl Glucosaminide Phosphate (AGP)

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NANANALipidSyntheticAGPs boost the innate immune response to infection with F. novicida.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahges and Dendritic cellsLRRQ9QUK6.fastaQ9QUK6835It provides Protectection to Mice from Pneumonic Tularemia.ELISA184907592008Pubchem Assay
PRRID_0273Carbohydrate moieties

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Candida albicans(fungi)NANACarbohydrateNaturalThe stimulation of mincle by carbohydrate moities, leads to the production of TNF-‚ç∫ by macrophages.MincleC type Lectin (CTL/CLR)MiceMacropahgesCarbohydrate binding motif (EPN)Q9R0Q8.fastaQ9R0Q8214Mincle plays a significant role in the mammalian immune response against the yeast.ELISA184907402008Pubchem Assay
PRRID_0273Carbohydrate moieties

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Candida albicans(fungi)NANACarbohydrateNaturalThe stimulation of mincle by carbohydrate moities, leads to the production of TNF-‚ç∫ by macrophages.MincleC type Lectin (CTL/CLR)MiceMacropahgesCarbohydrate binding motif (EPN)Q9R0Q8.fastaQ9R0Q8214Mincle plays a significant role in the mammalian immune response against the yeast.ELISA184907402008Pubchem Assay
PRRID_0276CL087

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NACOCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3NANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0276CL087

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NACOCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3NANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0277CL097

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NACCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58682.fastaP586821032It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0277CL097

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NACCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58682.fastaP586821032It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0284Flagellin

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Salmonella typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalThe binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micenonhemopoietic (radioresistant) cellsLRRQ9JLF7.fastaQ9JLF7859It has a immunostimulatory roleELISA184907172008Pubchem Assay
PRRID_0284Flagellin

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Salmonella typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalThe binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micenonhemopoietic (radioresistant) cellsLRRQ9JLF7.fastaQ9JLF7859It has a immunostimulatory roleELISA184907172008Pubchem Assay
PRRID_0285Flagellin

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Salmonella typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalThe binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micehemopoietic (radiosensitive) cellsLRRQ9JLF7.fastaQ9JLF7859It has a immunostimulatory roleELISA184907172008Pubchem Assay
PRRID_0285Flagellin

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Salmonella typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalThe binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micehemopoietic (radiosensitive) cellsLRRQ9JLF7.fastaQ9JLF7859It has a immunostimulatory roleELISA184907172008Pubchem Assay
PRRID_0290German Cockroach frass

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German Cockroach (others)NANAAllergenNaturalIt induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeutrophilsLRRQ9QUN7.fastaQ9QUN7784It is responisble for the immune response against the allergen having origin as German Cockroach frass.ELISA184247552008Pubchem Assay
PRRID_0290German Cockroach frass

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German Cockroach (others)NANAAllergenNaturalIt induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNeutrophilsLRRQ9QUN7.fastaQ9QUN7784It is responisble for the immune response against the allergen having origin as German Cockroach frass.ELISA184247552008Pubchem Assay
PRRID_0294Hyaluronan

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Sperm-secreted hyaluronidase (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalHyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceOvulated Cumulus-Oocyte Complexes(COCs)LRRQ9QUN7.fastaQ9QUN7784The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.Sperm accumulation assay184344142008Pubchem Assay
PRRID_0294Hyaluronan

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Sperm-secreted hyaluronidase (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalHyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceOvulated Cumulus-Oocyte Complexes(COCs)LRRQ9QUN7.fastaQ9QUN7784The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.Sperm accumulation assay184344142008Pubchem Assay
PRRID_0295Hyaluronan

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Sperm-secreted hyaluronidase (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalHyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceOvulated Cumulus-Oocyte Complexes(COCs)LRRQ9QUK6.fastaQ9QUK6835The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.Sperm accumulation assay184344142008Pubchem Assay
PRRID_0295Hyaluronan

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Sperm-secreted hyaluronidase (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)NaturalHyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceOvulated Cumulus-Oocyte Complexes(COCs)LRRQ9QUK6.fastaQ9QUK6835The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.Sperm accumulation assay184344142008Pubchem Assay
PRRID_0299Imiquimod (R837)

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0299Imiquimod (R837)

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NACC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0301Lipid A

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipidNaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0301Lipid A

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipidNaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0306Lipopolysaccharide (LPS)

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Escherichia coli 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalGalectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.Galectin-3Pattern recognition receptor (PRR)MiceBone Marrow Derived Macrophages.NAQ9JHE4 .fastaQ9JHE4423Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.ELISA186849692008Pubchem Assay
PRRID_0306Lipopolysaccharide (LPS)

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Escherichia coli 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalGalectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.Galectin-3Pattern recognition receptor (PRR)MiceBone Marrow Derived Macrophages.NAQ9JHE4 .fastaQ9JHE4423Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.ELISA186849692008Pubchem Assay
PRRID_0307Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0307Lipopolysaccharide (LPS)

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Burkholderia pseudomallei(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalStimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)HEK293 cellsLRRQ9QUK6.fastaQ9QUK6835It has a immunostimulatory roleELISA186914132008Pubchem Assay
PRRID_0310Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS stimulation leads to the activation of phospholipase CToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUK6.fastaQ9QUK6835It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0310Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS stimulation leads to the activation of phospholipase CToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUK6.fastaQ9QUK6835It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0314Lipoprotein

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Listeria monocytogenes (Bacteria)NANALipoproteinNaturalIt leads to the activation of NF-κB and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBone marrow-derived DCNAQ9QUN7.fastaQ9QUN7784It has a immunostimulatory roleCytokines assay186413402008Pubchem Assay
PRRID_0314Lipoprotein

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Listeria monocytogenes (Bacteria)NANALipoproteinNaturalIt leads to the activation of NF-κB and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceBone marrow-derived DCNAQ9QUN7.fastaQ9QUN7784It has a immunostimulatory roleCytokines assay186413402008Pubchem Assay
PRRID_0318Lipoteichoic Acid (LTA)

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-⍺ (TNF-⍺) and nitric oxide (NO).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)RAW 264.7NAQ9QUN7.fastaQ9QUN7784LTA contributes to E. faecalis–induced inflammatory responses.ELISA186349302008Pubchem Assay
PRRID_0318Lipoteichoic Acid (LTA)

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-⍺ (TNF-⍺) and nitric oxide (NO).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)RAW 264.7NAQ9QUN7.fastaQ9QUN7784LTA contributes to E. faecalis–induced inflammatory responses.ELISA186349302008Pubchem Assay
PRRID_0319Lipoteichoic Acid (LTA)

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S. aureus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalLTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-α production.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahgesNAQ9QUN7.fastaQ9QUN7784It resulted in the antibacterial response.ELISA186528902008Pubchem Assay
PRRID_0319Lipoteichoic Acid (LTA)

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S. aureus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalLTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-α production.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahgesNAQ9QUN7.fastaQ9QUN7784It resulted in the antibacterial response.ELISA186528902008Pubchem Assay
PRRID_0323Low Molecular Weight Hyaluronic Acid (LMW-HA)

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAGlycosaminoglycanNaturalIt leads to the production of antimicrobial peptide beta defensins 2.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dorsal skinNAQ9QUK6.fastaQ9QUK6835It leadsto the induction of an antibacterial response.ELISA186413492008Pubchem Assay
PRRID_0323Low Molecular Weight Hyaluronic Acid (LMW-HA)

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAGlycosaminoglycanNaturalIt leads to the production of antimicrobial peptide beta defensins 2.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Dorsal skinNAQ9QUK6.fastaQ9QUK6835It leadsto the induction of an antibacterial response.ELISA186413492008Pubchem Assay
PRRID_0324Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0324Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Newborn MiceAstrocytes and microgliaLRRP58681.fastaP586811050It induces a neuroinflammatory response in CNS.Cytokines assay184907632008Pubchem Assay
PRRID_0328P8 proteoglycolipid

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Trypanosoma (Leishmania pifanoi)NANAGlycolipidNaturalimmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835NALuciferase assay.182993402008Pubchem Assay
PRRID_0328P8 proteoglycolipid

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Trypanosoma (Leishmania pifanoi)NANAGlycolipidNaturalimmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophagesNAQ9QUK6.fastaQ9QUK6835NALuciferase assay.182993402008Pubchem Assay
PRRID_0331Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt leads to the increased p38 MAPK activity and produce antimicrobial peptide β-defensin-2 (mBD-2).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Pleural mesothelial cellsNAQ9QUN7.fastaQ9QUN7784PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.Antimicrobial assay186219102008Pubchem Assay
PRRID_0331Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt leads to the increased p38 MAPK activity and produce antimicrobial peptide β-defensin-2 (mBD-2).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Pleural mesothelial cellsNAQ9QUN7.fastaQ9QUN7784PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.Antimicrobial assay186219102008Pubchem Assay
PRRID_0332Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN stimulation leads to the activation of phospholipase CToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUN7.fastaQ9QUN7784It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0332Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN stimulation leads to the activation of phospholipase CToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacrophages and Dendritic cellsNAQ9QUN7.fastaQ9QUN7784It has the role in immuno inflammation.ELISA182339612008Pubchem Assay
PRRID_0333Plant polysaccharide (EP)

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Echinacea purpurea(plant)NANACarbohydrateNaturalIt leads to the activation of NF-κB and stimulates the production of IL-6, TNF, IL-12 and NO.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Peritoneal macrophagesNAQ9QUK6.fastaQ9QUK6835Echinacea polysaccharides have immunomodulatory activity.ELISA186183122008Pubchem Assay
PRRID_0333Plant polysaccharide (EP)

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Echinacea purpurea(plant)NANACarbohydrateNaturalIt leads to the activation of NF-κB and stimulates the production of IL-6, TNF, IL-12 and NO.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Peritoneal macrophagesNAQ9QUK6.fastaQ9QUK6835Echinacea polysaccharides have immunomodulatory activity.ELISA186183122008Pubchem Assay
PRRID_0336polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticThey produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSertoli cellsLRRQ99MB1.fastaQ99MB1905Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.ELISA185962192008Pubchem Assay
PRRID_0336polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticThey produce the proinflammatory molecule ICAM1 and secrete functionally active CCL2 chemokine.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)MiceSertoli cellsLRRQ99MB1.fastaQ99MB1905Poly (I:C) elicits both inflammatory and antiviral responses in Sertoli cells.ELISA185962192008Pubchem Assay
PRRID_0350T.g.HSP70

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T. gondii (others)MGSSHHHHHHSSGLVPRGSHMLEMADSPAVGIDLGTTYSCVGVWKNDAVEIIANDQGNRTTPSYVAFTDTERLVGDAAKNQVARNPENTIFDAKRLIGRKFDDPSVQSDMKHWPFKVIAGPGDKPLIEVTYQGEKKTFHPEEVSAMVLGKMKEIAEAYLGKEVKEAVITVLAYFNDSQRQATKDAGTIAGLSVLRIINEPTAAAIAYGLDKKGCGEMNVLIFDMGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVDFCVQDFKRKNRGKDISTNSRALRRLRTQCERTKRTLSSSIQATIEIDSLFEGIDYSVSISRARFEELCMDYFRNSLLPVEKVLKDSGIDKRSVSEVVLVGGSTRIPKIQQLITDFFNGKEPCRSINPDEAVAYGAAVQAAILKGVTSSQVQDLLLLDVALLSLGLETAGGVMTKLIERNTTIPTKKSQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFHLDGIPPAPRGVPQIEVTFDIDANGIMNVTAQDKSTGKSNQITITNDKGRLSASEIDRMVQEAEKYKAEDEQNKHRVEAKNGLENYCYHMRQTLDDEKLKDKISSEDRDTANKAIQEALDWLDKNQLAEKEEFEAKQKEVESVCTPIITKLYQAGAAAGGMPGGMGGMPGGMGGMPGGMGGMPGGMGSGC674ProteinNaturalIt leads to the activation of cytosolic phospholipase A2 and platelet-activating factor and activated the PAF production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceSpleenocytesNAQ9QUK6.fastaQ9QUK6835It induces the lethal anaphylactic reaction.NA186670352008Pubchem Assay
PRRID_0350T.g.HSP70

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T. gondii (others)MGSSHHHHHHSSGLVPRGSHMLEMADSPAVGIDLGTTYSCVGVWKNDAVEIIANDQGNRTTPSYVAFTDTERLVGDAAKNQVARNPENTIFDAKRLIGRKFDDPSVQSDMKHWPFKVIAGPGDKPLIEVTYQGEKKTFHPEEVSAMVLGKMKEIAEAYLGKEVKEAVITVLAYFNDSQRQATKDAGTIAGLSVLRIINEPTAAAIAYGLDKKGCGEMNVLIFDMGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVDFCVQDFKRKNRGKDISTNSRALRRLRTQCERTKRTLSSSIQATIEIDSLFEGIDYSVSISRARFEELCMDYFRNSLLPVEKVLKDSGIDKRSVSEVVLVGGSTRIPKIQQLITDFFNGKEPCRSINPDEAVAYGAAVQAAILKGVTSSQVQDLLLLDVALLSLGLETAGGVMTKLIERNTTIPTKKSQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFHLDGIPPAPRGVPQIEVTFDIDANGIMNVTAQDKSTGKSNQITITNDKGRLSASEIDRMVQEAEKYKAEDEQNKHRVEAKNGLENYCYHMRQTLDDEKLKDKISSEDRDTANKAIQEALDWLDKNQLAEKEEFEAKQKEVESVCTPIITKLYQAGAAAGGMPGGMGGMPGGMGGMPGGMGGMPGGMGSGC674ProteinNaturalIt leads to the activation of cytosolic phospholipase A2 and platelet-activating factor and activated the PAF production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceSpleenocytesNAQ9QUK6.fastaQ9QUK6835It induces the lethal anaphylactic reaction.NA186670352008Pubchem Assay
PRRID_0354Viral RNA

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Murine norovirus-1 (virus)NANANucleic AcidNaturalUpon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.MDA5Rig-like receptor (RLR)MiceBone marrow-derived DCNAQ8R5F7.fastaQ8R5F71025MDA5 limits MNV-1 replication.ELISA186361032008Pubchem Assay
PRRID_0354Viral RNA

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Murine norovirus-1 (virus)NANANucleic AcidNaturalUpon stimulation, it leads to the production of IFN-alpha, IL-6, MCP-1, TNFalpha and IFN-beta.MDA5Rig-like receptor (RLR)MiceBone marrow-derived DCNAQ8R5F7.fastaQ8R5F71025MDA5 limits MNV-1 replication.ELISA186361032008Pubchem Assay
PRRID_0360Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0360Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0361Carrageenan

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Dietary Products(others)C1C2C(C(O1)C(C(O2)O)O)OC3C(C(C(C(O3)CO)OS(=O)(=O)[O-])OC4C(C5C(C(O4)CO5)OC6C(C(C(C(O6)CO)OS(=O)(=O)[O-])O)O)O)ONACarbohydrateSyntheticIt has the its inhibitory effects on LPS-induced TLR4-mediated NF-kappaB activation.Deleted in malignant brain tumors 1 (DMBT1)Pattern recognition receptor (PRR)MiceNANAQ60997.fastaQ609972085Carrageenan inhibit DMBT1-mediated bacterial aggregation.ELISA191893102009Pubchem Assay
PRRID_0361Carrageenan

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Dietary Products(others)C1C2C(C(O1)C(C(O2)O)O)OC3C(C(C(C(O3)CO)OS(=O)(=O)[O-])OC4C(C5C(C(O4)CO5)OC6C(C(C(C(O6)CO)OS(=O)(=O)[O-])O)O)O)ONACarbohydrateSyntheticIt has the its inhibitory effects on LPS-induced TLR4-mediated NF-kappaB activation.Deleted in malignant brain tumors 1 (DMBT1)Pattern recognition receptor (PRR)MiceNANAQ60997.fastaQ609972085Carrageenan inhibit DMBT1-mediated bacterial aggregation.ELISA191893102009Pubchem Assay
PRRID_0362Chromosomal DNA

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S. gordonii (Bacteria)NANAWhole organismNaturalStimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0362Chromosomal DNA

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S. gordonii (Bacteria)NANAWhole organismNaturalStimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0364Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.SCARF1Scavenger receptor (SR)MiceMacropahgesNAQ68EF1.fastaQ68EF1474Macrophages phagocytose and kill C. neoformans and binding of these fungi to endothelial cells initiates tissue invasion.NA192376022009Pubchem Assay
PRRID_0364Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.SCARF1Scavenger receptor (SR)MiceMacropahgesNAQ68EF1.fastaQ68EF1474Macrophages phagocytose and kill C. neoformans and binding of these fungi to endothelial cells initiates tissue invasion.NA192376022009Pubchem Assay
PRRID_0365Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0365Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0366Dextran Sulfate Sodium (DSS)

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Dietary Products(others)CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O.NaNACarbohydrateSyntheticIt has the its inhibitory effects on LPS-induced TLR4-mediated NF-kappaB activation.Deleted in malignant brain tumors 1 (DMBT1)Pattern recognition receptor (PRR)MiceNANAQ60997.fastaQ609972085DSS inhibit DMBT1-mediated bacterial aggregation.ELISA191893102009Pubchem Assay
PRRID_0366Dextran Sulfate Sodium (DSS)

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Dietary Products(others)CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O.NaNACarbohydrateSyntheticIt has the its inhibitory effects on LPS-induced TLR4-mediated NF-kappaB activation.Deleted in malignant brain tumors 1 (DMBT1)Pattern recognition receptor (PRR)MiceNANAQ60997.fastaQ609972085DSS inhibit DMBT1-mediated bacterial aggregation.ELISA191893102009Pubchem Assay
PRRID_0368Hyaluronan

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAGlycosaminoglycanNaturalHyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin)NOD-like receptor (NLR)MiceMacropahgesNAQ8BHB0.fastaQ8BHB0953It participates in the inflammatory response to injury or the cytokine response to hyaluronan.ELISA192583282009Pubchem Assay
PRRID_0368Hyaluronan

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Host (Endogenous) (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAGlycosaminoglycanNaturalHyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin)NOD-like receptor (NLR)MiceMacropahgesNAQ8BHB0.fastaQ8BHB0953It participates in the inflammatory response to injury or the cytokine response to hyaluronan.ELISA192583282009Pubchem Assay
PRRID_0370Lipoprotein

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S. gordonii (Bacteria)NANALipoproteinNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0370Lipoprotein

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S. gordonii (Bacteria)NANALipoproteinNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0374Lipoteichoic Acid (LTA)

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S. gordonii (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0374Lipoteichoic Acid (LTA)

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S. gordonii (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0376Peptidoglycan (PGN)

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S. gordonii (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay
PRRID_0376Peptidoglycan (PGN)

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S. gordonii (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalStimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Mice (Murine)Bone-marrow derived Dendritic cellsLRRQ9QUN7.fastaQ9QUN7784This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.ELISA192845002009Pubchem Assay