Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0121	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0121	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0122	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0122	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0123	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0123	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0124	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0124	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0125	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0125	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0126	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0126	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0135	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0135	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0137	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0137	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0138	Mannose Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0138	Mannose Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0140	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0140	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0141	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0141	N-acetylmannosamine Click for more detail	Bacteria	CC(=O)NC1C(C(C(OC1O)CO)O)O	NA	Carbohydrate	Natural	Immunostimulant	Endo180	Mannose receptor (MR)	Human	NA	lectin-like domains	Q9UBG0.fasta	Q9UBG0	1479	NA	Sugar-Binding assay	12399458	2002	Pubchem Assay
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0153	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0156	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0159	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0162	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0164	Collagen Click for more detail	Host (Endogenous) (others)	MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM	1464	Protein	Natural	elicit innate immune response	Endo180 (Endocytic receptor 180)	Mannose receptor (MR)	Human	Endosomes	N-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domains	Q9UBG0.fasta	Q9UBG0	1479	Endo180 Functions in Cells as a Collagen Binding and Internalization Receptor	ELISA	12972549	2003	Pubchem Assay
PRRID_0164	Collagen Click for more detail	Host (Endogenous) (others)	MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM	1464	Protein	Natural	elicit innate immune response	Endo180 (Endocytic receptor 180)	Mannose receptor (MR)	Human	Endosomes	N-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domains	Q9UBG0.fasta	Q9UBG0	1479	Endo180 Functions in Cells as a Collagen Binding and Internalization Receptor	ELISA	12972549	2003	Pubchem Assay
PRRID_0165	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0165	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0166	GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0166	GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0167	GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0167	GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail	Gram-negative bacteria	NA	NA	Carbohydrate	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0169	HCV E1 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	triggers immune responses	DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)	C type Lectin (CTL/CLR)	Human	dendritic cells	NA	NA	NA	NA	promote HIV and Hepatitis C virus to infect T-cell from dendritic cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0169	HCV E1 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	triggers immune responses	DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)	C type Lectin (CTL/CLR)	Human	dendritic cells	NA	NA	NA	NA	promote HIV and Hepatitis C virus to infect T-cell from dendritic cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0170	HCV E1 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	triggers immune responses	DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein)	C type Lectin (CTL/CLR)	Human	endothelial cell populations, including hepatic sinusoidal endothelial cells	NA	NA	NA	NA	functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0170	HCV E1 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	triggers immune responses	DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein)	C type Lectin (CTL/CLR)	Human	endothelial cell populations, including hepatic sinusoidal endothelial cells	NA	NA	NA	NA	functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0171	HCV E2 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	elicit innate immune response	DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)	C type Lectin (CTL/CLR)	Human	dendritic cells	NA	NA	NA	NA	promote HIV and Hepatitis C virus to infect T-cell from dendritic cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0171	HCV E2 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	elicit innate immune response	DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)	C type Lectin (CTL/CLR)	Human	dendritic cells	NA	NA	NA	NA	promote HIV and Hepatitis C virus to infect T-cell from dendritic cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0172	HCV E2 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	elicit innate immune response	DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein)	C type Lectin (CTL/CLR)	Human	endothelial cell populations, including hepatic sinusoidal endothelial cells	NA	NA	NA	NA	functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0172	HCV E2 glycoproteins Click for more detail	Hepatitis C Virus (virus)	DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR	106	Glycoprotein	Natural	elicit innate immune response	DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein)	C type Lectin (CTL/CLR)	Human	endothelial cell populations, including hepatic sinusoidal endothelial cells	NA	NA	NA	NA	functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells	enzyme-linked immunosorbent assay	12634366	2003	NA
PRRID_0178	M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail	Gram-negative bacteria	NA	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0178	M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail	Gram-negative bacteria	NA	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0180	muramyl tripeptide Click for more detail	muramyl dipeptide derivative (others)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Synthetic	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0180	muramyl tripeptide Click for more detail	muramyl dipeptide derivative (others)	CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Synthetic	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	production of pro-inflammatory cytokines	NA	12527755	2003	Pubchem Assay
PRRID_0181	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0181	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HEK293T (human embryonic kidney 293T cells)	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	NA	12871942	2003	Pubchem Assay
PRRID_0187	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0187	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16.	Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16)	Scavenger receptor (SR)	Human	Macrophages and Dendritic cells	Chemokine domain	Q9H2A7.fasta	Q9H2A7	254	SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis.	ELISA	12902461	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0188	Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptide	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Macrophages	NA	Q9Y239.fasta	Q9Y239	953	Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation	NA	12527755	2003	Pubchem Assay
PRRID_0194	Conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Spore	Natural	It exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10.	DC-SIGN	C type Lectin (CTL/CLR)	Human	Macrophages and Dendritic cells	NA	NA	NA	NA	It mediates binding and internalization of Aspergillus fumigatus conidia.	ELISA	15494514	2004	NA
PRRID_0194	Conidia Click for more detail	Aspergillus fumigatus(fungi)	NA	NA	Spore	Natural	It exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10.	DC-SIGN	C type Lectin (CTL/CLR)	Human	Macrophages and Dendritic cells	NA	NA	NA	NA	It mediates binding and internalization of Aspergillus fumigatus conidia.	ELISA	15494514	2004	NA
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0195	Double-stranded ribonucleic acid (dsRNA) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	ELISA	14976262	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0196	dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0205	Influenza virus Click for more detail	Influenza A (virus)	NA	NA	Whole cell	Natural	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0205	Influenza virus Click for more detail	Influenza A (virus)	NA	NA	Whole cell	Natural	It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Alveolar and bronchial epithelial cells	NA	O15455.fasta	O15455	904	It causes pulmonary inflammation.	ELISA	15579900	2004	Pubchem Assay
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0206	Not Determined Click for more detail	Uropathogenic E.coli (Bacteria)	NA	NA	Others	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	macrophages and liver, kidney, and bladder epithelial cells	NA	NA	NA	NA	NA	NA	15001781	2004	NA
PRRID_0207	Opacity protein Click for more detail	Neisseria meningitidis (Bacteria)	MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF	273	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0207	Opacity protein Click for more detail	Neisseria meningitidis (Bacteria)	MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF	273	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0208	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0208	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Mannose-binding lectins	Mannose receptor (MR)	Human	NA	NA	B1PN75.fasta	B1PN75	38	MBL binding to N. meningitidis and increases complement activation and killing of organisms.	ELISA	15004183	2004	Pubchem Assay
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0211	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0212	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	leads to stimulation of innate immune cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	peripheral blood mononuclear cells (PBMCs)	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	ELISA	14976262	2004	Pubchem Assay
PRRID_0215	Soluble egg antigen (SEA) Click for more detail	S. mansoni (others)	MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH	354	Others	Natural	elicit innate immune response	L-SIGN	C type Lectin (CTL/CLR)	Human	Liver sinusoidal endothelial cells	NA	NA	NA	NA	NA	Binding assay	15184372	2004	NA
PRRID_0215	Soluble egg antigen (SEA) Click for more detail	S. mansoni (others)	MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH	354	Others	Natural	elicit innate immune response	L-SIGN	C type Lectin (CTL/CLR)	Human	Liver sinusoidal endothelial cells	NA	NA	NA	NA	NA	Binding assay	15184372	2004	NA
PRRID_0216	Soluble egg antigen (SEA) Click for more detail	S. mansoni (others)	MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH	354	Others	Natural	elicit innate immune response	DC-SIGN	C type Lectin (CTL/CLR)	Human	Liver sinusoidal endothelial cells	NA	NA	NA	NA	NA	Binding assay	15184372	2004	NA
PRRID_0216	Soluble egg antigen (SEA) Click for more detail	S. mansoni (others)	MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH	354	Others	Natural	elicit innate immune response	DC-SIGN	C type Lectin (CTL/CLR)	Human	Liver sinusoidal endothelial cells	NA	NA	NA	NA	NA	Binding assay	15184372	2004	NA
PRRID_0218	Biglycan Click for more detail	Endogenous (others)	MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT	238	Carbohydrate	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	synthesis of TNF-alpha and MIP-2.	Western blotting and ELISA.	16025156	2005	Pubchem Assay
PRRID_0218	Biglycan Click for more detail	Endogenous (others)	MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT	238	Carbohydrate	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	synthesis of TNF-alpha and MIP-2.	Western blotting and ELISA.	16025156	2005	Pubchem Assay
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0219	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0220	FK156 Click for more detail	NA	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0220	FK156 Click for more detail	NA	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0221	FK565 Click for more detail	NA	CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0221	FK565 Click for more detail	NA	CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C	NA	Peptide	Synthetic	It induces the secretion of the IL-8	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Monocytes	NA	Q9Y239.fasta	Q9Y239	953	It leads to the maturation and activation of the host cells.	ELISA	15617523	2005	Pubchem Assay
PRRID_0226	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0226	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocytic cell line	extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	15661917	2005	NA
PRRID_0232	crystallin Click for more detail	Host (Endogenous) (others)	MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS	173	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay
PRRID_0232	crystallin Click for more detail	Host (Endogenous) (others)	MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS	173	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay

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