Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0121 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0121 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0122 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0122 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0123 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0123 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0124 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0124 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0125 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0125 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0126 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0126 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0128 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Microvascular endothelial cells | LRR | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0128 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Microvascular endothelial cells | LRR | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0134 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0134 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0135 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0135 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0136 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0136 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0137 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0137 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0138 | Mannose Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0138 | Mannose Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0140 | N-acetylmannosamine Click for more detail | Bacteria | CC(=O)NC1C(C(C(OC1O)CO)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0140 | N-acetylmannosamine Click for more detail | Bacteria | CC(=O)NC1C(C(C(OC1O)CO)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0141 | N-acetylmannosamine Click for more detail | Bacteria | CC(=O)NC1C(C(C(OC1O)CO)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0141 | N-acetylmannosamine Click for more detail | Bacteria | CC(=O)NC1C(C(C(OC1O)CO)O)O | NA | Carbohydrate | Natural | Immunostimulant | Endo180 | Mannose receptor (MR) | Human | NA | lectin-like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | NA | Sugar-Binding assay | 12399458 | 2002 | Pubchem Assay |
| PRRID_0143 | OspA Click for more detail | Borrelia burgdorferi(Bacteria) | MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK | NA | Lipoprotein | Natural | immunostimulantt | Toll-like receptor 2 (TLR2)+unknown | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | human hyporesponsiveness to OspA vaccination | NA | 12091878 | 2002 | NA |
| PRRID_0143 | OspA Click for more detail | Borrelia burgdorferi(Bacteria) | MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK | NA | Lipoprotein | Natural | immunostimulantt | Toll-like receptor 2 (TLR2)+unknown | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | human hyporesponsiveness to OspA vaccination | NA | 12091878 | 2002 | NA |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0164 | Collagen Click for more detail | Host (Endogenous) (others) | MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM | 1464 | Protein | Natural | elicit innate immune response | Endo180 (Endocytic receptor 180) | Mannose receptor (MR) | Human | Endosomes | N-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | Endo180 Functions in Cells as a Collagen Binding and Internalization Receptor | ELISA | 12972549 | 2003 | Pubchem Assay |
| PRRID_0164 | Collagen Click for more detail | Host (Endogenous) (others) | MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM | 1464 | Protein | Natural | elicit innate immune response | Endo180 (Endocytic receptor 180) | Mannose receptor (MR) | Human | Endosomes | N-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domains | Q9UBG0.fasta | Q9UBG0 | 1479 | Endo180 Functions in Cells as a Collagen Binding and Internalization Receptor | ELISA | 12972549 | 2003 | Pubchem Assay |
| PRRID_0165 | Escherichia coli Click for more detail | E. coli(Bacteria) | NA | NA | Whole cell | Natural | The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16. | Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16) | Scavenger receptor (SR) | Human | Macrophages and Dendritic cells | Chemokine domain | Q9H2A7.fasta | Q9H2A7 | 254 | SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis. | ELISA | 12902461 | 2003 | Pubchem Assay |
| PRRID_0165 | Escherichia coli Click for more detail | E. coli(Bacteria) | NA | NA | Whole cell | Natural | The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16. | Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16) | Scavenger receptor (SR) | Human | Macrophages and Dendritic cells | Chemokine domain | Q9H2A7.fasta | Q9H2A7 | 254 | SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis. | ELISA | 12902461 | 2003 | Pubchem Assay |
| PRRID_0166 | GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9HC29.fasta | Q9HC29 | 1040 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0166 | GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9HC29.fasta | Q9HC29 | 1040 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0167 | GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0167 | GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0169 | HCV E1 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | triggers immune responses | DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) | C type Lectin (CTL/CLR) | Human | dendritic cells | NA | NA | NA | NA | promote HIV and Hepatitis C virus to infect T-cell from dendritic cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0169 | HCV E1 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | triggers immune responses | DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) | C type Lectin (CTL/CLR) | Human | dendritic cells | NA | NA | NA | NA | promote HIV and Hepatitis C virus to infect T-cell from dendritic cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0170 | HCV E1 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | triggers immune responses | DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein) | C type Lectin (CTL/CLR) | Human | endothelial cell populations, including hepatic sinusoidal endothelial cells | NA | NA | NA | NA | functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0170 | HCV E1 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | triggers immune responses | DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein) | C type Lectin (CTL/CLR) | Human | endothelial cell populations, including hepatic sinusoidal endothelial cells | NA | NA | NA | NA | functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0171 | HCV E2 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | elicit innate immune response | DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) | C type Lectin (CTL/CLR) | Human | dendritic cells | NA | NA | NA | NA | promote HIV and Hepatitis C virus to infect T-cell from dendritic cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0171 | HCV E2 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | elicit innate immune response | DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) | C type Lectin (CTL/CLR) | Human | dendritic cells | NA | NA | NA | NA | promote HIV and Hepatitis C virus to infect T-cell from dendritic cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0172 | HCV E2 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | elicit innate immune response | DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein) | C type Lectin (CTL/CLR) | Human | endothelial cell populations, including hepatic sinusoidal endothelial cells | NA | NA | NA | NA | functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0172 | HCV E2 glycoproteins Click for more detail | Hepatitis C Virus (virus) | DAWDMMMNWSPTTALVVSQLLRIPQAVVDIVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGTQTTGRVAARNAHGFTSLFSPGASQNLQLINTNGSWHINR | 106 | Glycoprotein | Natural | elicit innate immune response | DC-SIGNR (Dendritic cell-specific ICAM-3-grabbing nonintegrin related protein) | C type Lectin (CTL/CLR) | Human | endothelial cell populations, including hepatic sinusoidal endothelial cells | NA | NA | NA | NA | functions as an attachment factor for HIV and is expressed on liver sinusoidal endothelial cells | enzyme-linked immunosorbent assay | 12634366 | 2003 | NA |
| PRRID_0178 | M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail | Gram-negative bacteria | NA | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0178 | M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail | Gram-negative bacteria | NA | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0180 | muramyl tripeptide Click for more detail | muramyl dipeptide derivative (others) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Synthetic | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0180 | muramyl tripeptide Click for more detail | muramyl dipeptide derivative (others) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Synthetic | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0181 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0181 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0187 | Staphylococcus aureus Click for more detail | S. aureus (Bacteria) | NA | NA | Whole cell | Natural | The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16. | Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16) | Scavenger receptor (SR) | Human | Macrophages and Dendritic cells | Chemokine domain | Q9H2A7.fasta | Q9H2A7 | 254 | SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis. | ELISA | 12902461 | 2003 | Pubchem Assay |
| PRRID_0187 | Staphylococcus aureus Click for more detail | S. aureus (Bacteria) | NA | NA | Whole cell | Natural | The recognition specificity for bacteria is determine by the chemokine domain of SR-PSOX/CXCL16. | Scavenger receptor PSOX/CXCL16 (SR-PSOX/CXCL16) | Scavenger receptor (SR) | Human | Macrophages and Dendritic cells | Chemokine domain | Q9H2A7.fasta | Q9H2A7 | 254 | SR-PSOX/CXCL16 mediates bacterial adhesion and phagocytosis. | ELISA | 12902461 | 2003 | Pubchem Assay |
| PRRID_0188 | Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0188 | Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0194 | Conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Spore | Natural | It exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10. | DC-SIGN | C type Lectin (CTL/CLR) | Human | Macrophages and Dendritic cells | NA | NA | NA | NA | It mediates binding and internalization of Aspergillus fumigatus conidia. | ELISA | 15494514 | 2004 | NA |
| PRRID_0194 | Conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Spore | Natural | It exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10. | DC-SIGN | C type Lectin (CTL/CLR) | Human | Macrophages and Dendritic cells | NA | NA | NA | NA | It mediates binding and internalization of Aspergillus fumigatus conidia. | ELISA | 15494514 | 2004 | NA |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0205 | Influenza virus Click for more detail | Influenza A (virus) | NA | NA | Whole cell | Natural | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0205 | Influenza virus Click for more detail | Influenza A (virus) | NA | NA | Whole cell | Natural | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0206 | Not Determined Click for more detail | Uropathogenic E.coli (Bacteria) | NA | NA | Others | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | macrophages and liver, kidney, and bladder epithelial cells | NA | NA | NA | NA | NA | NA | 15001781 | 2004 | NA |
| PRRID_0206 | Not Determined Click for more detail | Uropathogenic E.coli (Bacteria) | NA | NA | Others | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | macrophages and liver, kidney, and bladder epithelial cells | NA | NA | NA | NA | NA | NA | 15001781 | 2004 | NA |
| PRRID_0207 | Opacity protein Click for more detail | Neisseria meningitidis (Bacteria) | MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF | 273 | Protein | Natural | elicit innate immune response | Mannose-binding lectins | Mannose receptor (MR) | Human | NA | NA | B1PN75.fasta | B1PN75 | 38 | MBL binding to N. meningitidis and increases complement activation and killing of organisms. | ELISA | 15004183 | 2004 | Pubchem Assay |
| PRRID_0207 | Opacity protein Click for more detail | Neisseria meningitidis (Bacteria) | MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF | 273 | Protein | Natural | elicit innate immune response | Mannose-binding lectins | Mannose receptor (MR) | Human | NA | NA | B1PN75.fasta | B1PN75 | 38 | MBL binding to N. meningitidis and increases complement activation and killing of organisms. | ELISA | 15004183 | 2004 | Pubchem Assay |
| PRRID_0208 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | elicit innate immune response | Mannose-binding lectins | Mannose receptor (MR) | Human | NA | NA | B1PN75.fasta | B1PN75 | 38 | MBL binding to N. meningitidis and increases complement activation and killing of organisms. | ELISA | 15004183 | 2004 | Pubchem Assay |
| PRRID_0208 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | elicit innate immune response | Mannose-binding lectins | Mannose receptor (MR) | Human | NA | NA | B1PN75.fasta | B1PN75 | 38 | MBL binding to N. meningitidis and increases complement activation and killing of organisms. | ELISA | 15004183 | 2004 | Pubchem Assay |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0215 | Soluble egg antigen (SEA) Click for more detail | S. mansoni (others) | MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH | 354 | Others | Natural | elicit innate immune response | L-SIGN | C type Lectin (CTL/CLR) | Human | Liver sinusoidal endothelial cells | NA | NA | NA | NA | NA | Binding assay | 15184372 | 2004 | NA |
| PRRID_0215 | Soluble egg antigen (SEA) Click for more detail | S. mansoni (others) | MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH | 354 | Others | Natural | elicit innate immune response | L-SIGN | C type Lectin (CTL/CLR) | Human | Liver sinusoidal endothelial cells | NA | NA | NA | NA | NA | Binding assay | 15184372 | 2004 | NA |
| PRRID_0216 | Soluble egg antigen (SEA) Click for more detail | S. mansoni (others) | MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH | 354 | Others | Natural | elicit innate immune response | DC-SIGN | C type Lectin (CTL/CLR) | Human | Liver sinusoidal endothelial cells | NA | NA | NA | NA | NA | Binding assay | 15184372 | 2004 | NA |
| PRRID_0216 | Soluble egg antigen (SEA) Click for more detail | S. mansoni (others) | MSGGKQHNAVSIPVNREQRSFEKQRRDLLTGLEHGGGAHRGNSIAPYTEDWPSTVDNWIDSSWKRWDDDMRRLRRGMFALLPLDTFSIGILENPFALMHQMDRQIQDIRERMGSLDVPSTGSVNDFLKDAYEVGEDGKVHFKVRFDAQGFAPQDINVTSSENRVTVHAKKETTTDGRKCSREFCRMVQLPKSIDDSQLKCRMTDDGVLMLEAPVKVDQNQSLTLNESGQVAVRPKSDNQIKAVPASQALVAKGVHGLSYVDDGSGGKRLHVEVAVDPVYKPEDLFVNVDSNRVVVSGRHHKQKSDQHGRSSSFAEFSQSYAIPETVDPLSVSAQVVGNTLVLEAPLEKQHAITH | 354 | Others | Natural | elicit innate immune response | DC-SIGN | C type Lectin (CTL/CLR) | Human | Liver sinusoidal endothelial cells | NA | NA | NA | NA | NA | Binding assay | 15184372 | 2004 | NA |
| PRRID_0218 | Biglycan Click for more detail | Endogenous (others) | MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT | 238 | Carbohydrate | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | synthesis of TNF-alpha and MIP-2. | Western blotting and ELISA. | 16025156 | 2005 | Pubchem Assay |
| PRRID_0218 | Biglycan Click for more detail | Endogenous (others) | MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT | 238 | Carbohydrate | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | synthesis of TNF-alpha and MIP-2. | Western blotting and ELISA. | 16025156 | 2005 | Pubchem Assay |
| PRRID_0219 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0219 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0220 | FK156 Click for more detail | NA | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0220 | FK156 Click for more detail | NA | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0221 | FK565 Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0221 | FK565 Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0226 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0226 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0232 | crystallin Click for more detail | Host (Endogenous) (others) | MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS | 173 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |
| PRRID_0232 | crystallin Click for more detail | Host (Endogenous) (others) | MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS | 173 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |