| Primary information |
|---|
| PRRID | PRRID_0134 |
| Ligand Name | Mannan |
| Source | S. cerevisiae (Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Polysaccharides |
| Occurence | Natural |
| Role of Ligand | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Monocytes |
| Domain | NA |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | This leads to the inflammatory response. |
| Assay used | ELISA |
| PMID | 12222939 |
| Year of Publication | 2002 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0134 |
| Ligand Name | Mannan |
| Source | S. cerevisiae (Bacteria) |
| Sequence of ligand | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC |
| Length | NA |
| Type | Polysaccharides |
| Occurence | Natural |
| Role of Ligand | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Monocytes |
| Domain | NA |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | This leads to the inflammatory response. |
| Assay used | ELISA |
| PMID | 12222939 |
| Year of Publication | 2002 |
| Pubchem assay | Pubchem Assay |