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ID1089Sequence(GSGAGA)nNameSilk fibroin peptide (3,000 Da)Nature of peptide or cargoAnti-inflammatoryAssayHistochemical analysisTissue permeabilitySignificant permeability of the silk peptide can be seen in histochemical imagesTissue SampleEar of micePUBMED ID22189681
ID1090Sequence(GSGAGA)nNameSilk fibroin peptide (3,000 Da)Nature of peptide or cargoAnti-inflammatoryAssayRT-PCR, Western blottingTissue permeabilitySignificant decrease in translation of COX-2, IL-6 and IL-1β in presence of silk peptide +Tat-SOD can be seen in western blot imagesTissue SampleHaCaT keratinocytesPUBMED ID22189681
ID1254SequenceVTHRLAGLLSRSGGM
VKSNFVPTNVGSKAF
NameCGRP receptor antagonist CGRP(8-37)Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodellingAssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test.Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~24.5 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~36.5 mm2).Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats.PUBMED ID8584255
ID1255SequenceVTHRLAGLLSRSGGM
VKSNFVPTNVGSKAF
NameCGRP receptor antagonist CGRP(8-37)Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodellingAssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test.Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~17 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~25 mm2).Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats.PUBMED ID8584255
ID1256SequenceVTHRLAGLLSRSGGM
VKSNFVPTNVGSKAF
NameCGRP receptor antagonist CGRP(8-37)Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodellingAssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test.Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~13 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~16.5 mm2).Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats.PUBMED ID8584255
ID1257SequenceVTHRLAGLLSRSGGM
VKSNFVPTNVGSKAF
NameCGRP receptor antagonist CGRP(8-37)Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodellingAssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test.Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~12 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~14 mm2).Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats.PUBMED ID8584255
ID1258SequenceVTHRLAGLLSRSGGM
VKSNFVPTNVGSKAF
NameCGRP receptor antagonist CGRP(8-37)Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodellingAssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test.Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~7 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~13.5 mm2).Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats.PUBMED ID8584255
ID1267SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of number of cupsTissue permeabilityMeasurement of number of cups: Control:1.5 , Test:3Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1268SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of number of cupsTissue permeabilityMeasurement of number of cups: Control:4 , Test:9Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1269SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of number of cupsTissue permeabilityMeasurement of number of cups: Control:4.5 , Test:7.5Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1270SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of number of cupsTissue permeabilityMeasurement of number of cups: Control:7 , Test:15Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1271SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of E2(Erection)Tissue permeabilityMeasurement of E2(Erection): Control:15 , Test:26Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1272SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of E2(Erection)Tissue permeabilityMeasurement of E2(Erection): Control:4 , Test:11Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1273SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of E2(Erection)Tissue permeabilityMeasurement of E2(Erection): Control:6 , Test:12Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1274SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of E2(Erection)Tissue permeabilityMeasurement of E2(Erection): Control:11 , Test:24Tissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1275SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first cupTissue permeabilityMeasurement of latency of first cup: Control:44 minutes , Test:38 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1276SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first cupTissue permeabilityMeasurement of latency of first cup: Control:25.5 minutes , Test:19 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1277SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first cupTissue permeabilityMeasurement of latency of first cup: Control:39 minutes , Test:32 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1278SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first cupTissue permeabilityMeasurement of latency of first cup: Control:23 minutes , Test:15 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1279SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first E2(Erection)Tissue permeabilityMeasurement of latency of first E2(Erection): Control:29 minutes , Test:31 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1280SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first E2(Erection)Tissue permeabilityMeasurement of latency of first E2(Erection): Control:32 minutes , Test:16 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1281SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first E2(Erection)Tissue permeabilityMeasurement of latency of first E2(Erection): Control:9 minutes , Test:3 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1282SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first E2(Erection)Tissue permeabilityMeasurement of latency of first E2(Erection): Control:3.5 minutes , Test:2 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1283SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of number of cupsTissue permeabilityMeasurement of number of first cup: Control:7 minutes , Test:20.2 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1284SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of E2(Erection)Tissue permeabilityMeasurement of number of first E2(Erection): Control:11 minutes , Test:35 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1285SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first cupTissue permeabilityMeasurement of latency of first cup: Control:23 minutes , Test:10 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1286SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assay, Measurement of latency of first E2(Erection)Tissue permeabilityMeasurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutesTissue SampleIn castrated testosterone treated ratsPUBMED ID8156912
ID1287SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assayTissue permeabilityTime course of distribution of radioactively labelled peptide: Control:6 minutes , Test:20 minutesTissue SampleThree-month-old diabetic ratsPUBMED ID8156912
ID1288SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadioactive assayTissue permeabilityTime course of distribution of radioactively labelled peptide:Control:5.5 minutes , Test:21.5 minutesTissue SampleSpontaneous high blood pressure rats(SHR)PUBMED ID8156912
ID1348SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameVasoactive intestinal peptide (VIP)Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man.AssayLabelled peptide was detected and quantified by measuring radioactivity in a gamma counterTissue permeability0.6% of the applied material was found in the penile tissueTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ.PUBMED ID1522236
ID1349SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayLabelled peptide was detected and quantified by measuring radioactivity in a gamma counterTissue permeability5% of the applied material was found in the penile tissueTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ.PUBMED ID1522236
ID1350SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayLabelled peptide was detected and quantified by measuring radioactivity in a gamma counterTissue permeability2.5% of the applied material was found in the penile tissueTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ.PUBMED ID1522236
ID1351SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayLabelled peptide was detected and quantified by measuring radioactivity in a gamma counterTissue permeability1.25% of the applied material was found in the penile tissueTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ.PUBMED ID1522236
ID1352SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.Tissue permeabilityApproximately 0.6% incorporation per 10 ml blood as a percentage of the total radioactivity appliedTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ to check sytemic dispersion.PUBMED ID1522236
ID1353SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.Tissue permeabilityApproximately 0.55% incorporation per 10 ml blood as a percentage of the total radioactivity appliedTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ to check sytemic dispersion.PUBMED ID1522236
ID1354SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameStearyl-VIPNature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.AssayRadiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter.Tissue permeabilityApproximately 0.4% incorporation per 10 ml blood as a percentage of the total radioactivity appliedTissue SampleRats with reduced sexual potential due to castration were employed for topical application on their penile organ to check sytemic dispersion.PUBMED ID1522236
ID1380SequenceSKYALVDASLKMSDP
NRFRGKDLPVLDQL
NameHSV-1 gD 1-29 (group1)Nature of peptide or cargoIntranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responsesAssayFACSTissue permeabilityDetectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels.Tissue SampleNasal cavity of New Zealand White rabbitsPUBMED ID20089796
ID1383SequenceAPQIVRGASEDVRK
QPYNLTIAWFRMGG
NameHSV-1 gD 77-104 (group-1)Nature of peptide or cargoIntranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responsesAssayFACSTissue permeabilityDetectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels.Tissue SampleNasal cavity of New Zealand White rabbitsPUBMED ID20089796
ID1384SequenceTIAWFRMGGNCAIP
ITVMEYTECSYNKS
NameHSV-1 gD 96-123 (group 3)Nature of peptide or cargoIntranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responsesAssayFACSTissue permeabilityDetectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levelsTissue SampleNasal cavity of New Zealand White rabbitsPUBMED ID20089796
ID1389SequenceQRTVAVYSLKIAGWH
GPKAPYTSTLLPPEL
NameHSV-1 gD 228-257(group-3)Nature of peptide or cargoIntranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responsesAssayFACSTissue permeabilityDetectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levelsTissue SampleNasal cavity of New Zealand White rabbitsPUBMED ID20089796
ID1390SequenceICGIVYWMRRHTQKA
PKRIRLPHIRED
NameHSV-1 gD 332-358 (group-3)Nature of peptide or cargoIntranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responsesAssayFACSTissue permeabilityDetectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levelsTissue SampleNasal cavity of New Zealand White rabbitsPUBMED ID20089796
ID1425SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameVasoactive intestinal peptide (VIP)Nature of peptide or cargoPotent cAMP-dependent stimulus of both fluid and protein secretion from the rat and rabbit main lacrimal glandAssayTear film osmolarityTissue permeabilityOsmolarity measurements: t=0 min., VIP/Buffer=330/314.5mOsm/l; t=16 min., VIP/Buffer=315/313.5mOsm/lTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1426SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameVasoactive intestinal peptide (VIP)Nature of peptide or cargoPotent cAMP-dependent stimulus of both fluid and protein secretion from the rat and rabbit main lacrimal glandAssayTear film osmolarityTissue permeabilityOsmolarity measurements: t=0 min., VIP/Buffer=320/318mOsm/l; t=6 min., VIP/Buffer=303.5/310mOsm/l; t=16 min., VIP/Buffer=310/314mOsm/lTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1427SequenceHSDAVFTDNYTRLR
KQMAVKKYLNSILN
NameVasoactive intestinal peptide (VIP)Nature of peptide or cargoPotent cAMP-dependent stimulus of both fluid and protein secretion from the rat and rabbit main lacrimal glandAssayOsmolarity and tear volume measurementsTissue permeabilityOsmolarity measurements: t=0 min., VIP/Buffer=315/320mOsm/l; t=6 min., VIP/Buffer=301/314mOsm/l; t=16 min., VIP/Buffer=308/313mOsm/l; Volume measurement: VIP/Buffer= 17µl/7µlTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1428SequenceHSDGTLTSELSRLRD
RARLQRLLQGLL
NameSecretinNature of peptide or cargoSecretin stimulates the release of a watery bicarbonate solution from the pancreatic and bile duct epithelium.AssayTear film osmolarityTissue permeabilityCaused decrease in tear film osmolarityTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1429SequenceHSDGTLTSELSRLRD
RARLQRLLQGLL
NameSecretinNature of peptide or cargoSecretin stimulates the release of a watery bicarbonate solution from the pancreatic and bile duct epithelium.AssayTear film osmolarityTissue permeabilityCaused decrease in tear film osmolarityTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1430SequenceHSDGTLTSELSRLRD
RARLQRLLQGLL
NameSecretinNature of peptide or cargoSecretin stimulates the release of a watery bicarbonate solution from the pancreatic and bile duct epithelium.AssayOsmolarity and tear volume measurementsTissue permeabilityCaused decrease in tear film osmolarity, Tear volume: VIP/Buffer= 5.0±0.8µl/5.5±0.5µlTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1431SequenceHSQGTFTSDYSKYLD
SRRAQDFVQWLMNT
NameGlucagonNature of peptide or cargoThe pancreas releases glucagon when the concentration of glucose in the bloodstream falls too low in order to raise glucose levelsAssayTear film osmolarityTissue permeabilityOsmolarity measurements: t=0 min., Glucagon/Buffer=311/312.5mOsm/l; t=6 min., Glucagon/Buffer=304/306.5mOsm/l; t=16 min., Glucagon/Buffer=305/307.5mOsm/lTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1432SequenceHSQGTFTSDYSKYLD
SRRAQDFVQWLMNT
NameGlucagonNature of peptide or cargoThe pancreas releases glucagon when the concentration of glucose in the bloodstream falls too low in order to raise glucose levelsAssayOsmolarity and tear volume measurementsTissue permeabilityOsmolarity measurements: t=0 min., Glucagon/Buffer=310/308mOsm/l; t=6 min., Glucagon/Buffer=301/306mOsm/l; t=16 min., Glucagon/Buffer=305/307mOsm/l; Volume measurement: Glucagon/Buffer= 11.5µl/5.2µlTissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory ductPUBMED ID2365569
ID1503SequenceSKYALVDASLKMADP
NRFRGKDLPVLDQL
NamegD 1-29 (group 1)Nature of peptide or cargonot mentionedAssayELISA, Antibody assay, Peptide specific T-cell assaysTissue permeabilityFailed to induce significant IgA titers (p > 1).Tissue SampleeyePUBMED ID15603887