| ID | 1348 | |
| PMID | 1522236 | |
| Year | 1992 | |
| Sequence | HSDAVFTDNYTRLR KQMAVKKYLNSILN | |
| Name | Vasoactive intestinal peptide (VIP) | |
| Length | 28 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | VIP | |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. | |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter | |
| Enhancer | Before testing, each male was put in a separate cage for around one hour, then introduced to a receptive female, their mounts plus intromissions were recorded over a period of 15 min. | |
| Properties of enhancer | Not mentioned | |
| Concentration | 20 µl saline solution of 1 µg/ml experimental drug mixed with 10 µl DMSO and directly applied on the sex organ | |
| Incubation time | 15 minutes | |
| Tissue permeability (value with units) | 0.6% of the applied material was found in the penile tissue | |
| Tissue Sample | Rats with reduced sexual potential due to castration were employed for topical application on their penile organ. | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O) CC(=O)N)CC(C)C)[C@H](CC)C)CO)CC(=O)N)CC(C)C)Cc1ccc(cc1)O) CCCCN)CCCCN)C(C)C)C)CCSC)CCC(=O)N)CCCCN)CCCNC(=N)N) CC(C)C)CCCNC(=N)N)[C@H](O)C)Cc1ccc(cc1)O)CC(=O)N)CC(=O)O)[C@H](O)C) Cc1ccccc1)C(C)C)C)CC(=O)O)CO)Cc1[nH]cnc1 | |