Details of TopicalPdb ID 1354
| ID | 1354 | |
| PMID | 1522236 | |
| Year | 1992 | |
| Sequence | HSDAVFTDNYTRLR KQMAVKKYLNSILN | |
| Name | Stearyl-VIP | |
| Length | 28 | |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Derivative of VIP | |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Radiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter. | |
| Enhancer | Animals were cannulated at the carotid artery (under anesthesia), blood aliquots were removed and tested. | |
| Properties of enhancer | Not mentioned | |
| Concentration | Each animal received, by topical application, 1.6 x 106 cpm of the labeled analogue, in a mixture containing 26 µl DMSO and 10 µl saline. | |
| Incubation time | 60 minutes | |
| Tissue permeability (value with units) | Approximately 0.4% incorporation per 10 ml blood as a percentage of the total radioactivity applied | |
| Tissue Sample | Rats with reduced sexual potential due to castration were employed for topical application on their penile organ to check sytemic dispersion. | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |