Details of TopicalPdb ID 1269
| ID | 1269 | |
| PMID | 8156912 | |
| Year | 1994 | |
| Sequence | HSDAVFTDNYTRLR KQMAVKKYLNSILN | |
| Name | Stearyl-VIP | |
| Length | 28 | |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Derivative of VIP | |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Radioactive assay, Measurement of number of cups | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | Each rat received 30-50 µg Stearyl-VIP in about 10 µl ointment (2 g lubricant [K-Y Vaginal Lubricating Jelly], 10 mg Stearyl-VIP, and 130 µl of DMSO). | |
| Incubation time | 45 minutes | |
| Tissue permeability (value with units) | Measurement of number of cups: Control:4.5 , Test:7.5 | |
| Tissue Sample | In castrated testosterone treated rats | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
| |
| SMILES | N.A. | |