| PRIMARY INFORMATION |
|---|
| ID | 1352 |
| PMID | 1522236 |
| Year | 1992 |
| Sequence | HSDAVFTDNYTRLR
KQMAVKKYLNSILN |
| Name | Stearyl-VIP |
| Length | 28 |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | Derivative of VIP |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Radiolabelling assay is used to determine incorporation per 10 ml blood as a percentage of the total radioactivity applied using gamma counter. |
| Enhancer | Animals were cannulated at the carotid artery (under anesthesia), blood aliquots were removed and tested. |
| Properties of enhancer | Not mentioned |
| Concentration | Each animal received, by topical application, 1.6 x 106 cpm of the labeled analogue, in a mixture containing 26 µl DMSO and 10 µl saline. |
| Incubation time | 15 minutes |
| Tissue permeability (value with units) | Approximately 0.6% incorporation per 10 ml blood as a percentage of the total radioactivity applied |
| Tissue Sample | Rats with reduced sexual potential due to castration were employed for topical application on their penile organ to check sytemic dispersion. |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
