| PRIMARY INFORMATION |
|---|
| ID | 1286 |
| PMID | 8156912 |
| Year | 1994 |
| Sequence | HSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN |
| Name | Stearyl-Nle17- VIP |
| Length | 28 |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | Nle=Norleucine |
| Origin of Peptide | Derivative of VIP |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Radioactive assay, Measurement of latency of first E2(Erection) |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 31.2 µl, 10% Sefsol and 2.4 mg Stearyl-Nle-VIP in 31.2 µl DMSO (l-2 µl/rat) |
| Incubation time | 45 minutes |
| Tissue permeability (value with units) | Measurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutes |
| Tissue Sample | In castrated testosterone treated rats |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
