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Details of TopicalPdb ID 1286

PRIMARY INFORMATION
ID1286
PMID8156912
Year1994
SequenceHSDAVFTDNYTRLR
KQ-Nle-AVKKYLNSILN
NameStearyl-Nle17- VIP
Length28
N-Terminal ModificationStearic acid fused on N-terminus by amide bond
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNle=Norleucine
Origin of PeptideDerivative of VIP
Nature of Peptide/CargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats.
MechanismVIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioactive assay, Measurement of latency of first E2(Erection)
EnhancerNone
Properties of enhancerNot applicable
Concentration31.2 µl, 10% Sefsol and 2.4 mg Stearyl-Nle-VIP in 31.2 µl DMSO (l-2 µl/rat)
Incubation time45 minutes
Tissue permeability (value with units)Measurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutes
Tissue SampleIn castrated testosterone treated rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.