ID | 1389 | |
PMID | 20089796 | |
Year | 2010 | |
Sequence | QRTVAVYSLKIAGWH GPKAPYTSTLLPPEL | |
Name | HSV-1 gD 228-257(group-3) | |
Length | 30 | |
N-Terminal Modification | Free | |
C-Terminal Modification | Free | |
Linear/ Cyclic | Linear | |
Chirality | L | |
Chemical Modification | None | |
Origin of Peptide | T-cell epitope peptide identified from HSV1-gD | |
Nature of Peptide/Cargo | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | |
Mechanism | Not mentioned | |
Cargo Sequence/Structure | None | |
Name of cargo | Not applicable | |
Assay | FACS | |
Enhancer | CpG adjuvant | |
Properties of enhancer | Not mentioned | |
Concentration | 50 µl per nasal cavity | |
Incubation time | Immunized on 0,14 and 21 days. Euthanized after 10 days. | |
Tissue permeability (value with units) | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | |
Tissue Sample | Nasal cavity of New Zealand White rabbits | |
Ex vivo/In vivo/In vitro | in vivo | |
STRUCTURE |
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SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N [C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O)CC(C)C)CCC (=O)O)CCC)CCC)CC(C)C)CC(C)C)[C@H](O)C)CO)[C@H](O)C)Cc1ccc(cc1)O) CCC)C)CCCCN)CCC)Cc1[nH]cnc1)Cc1c[nH]c2c1cccc2)C)[C@H](CC)C)CCCCN)CC(C)C)CO) Cc1ccc(cc1)O)C(C)C)C)C(C)C)[C@H](O)C)CCCNC(=N)N)CCC(=O)N |