Details of TopicalPdb ID 1283
| ID | 1283 | |
| PMID | 8156912 | |
| Year | 1994 | |
| Sequence | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | |
| Name | Stearyl-Nle17- VIP | |
| Length | 28 | |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | Nle=Norleucine | |
| Origin of Peptide | Derivative of VIP | |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Radioactive assay, Measurement of number of cups | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | 31.2 µl, 10% Sefsol and 2.4 mg Stearyl-Nle-VIP in 31.2 µl DMSO (l-2 µl/rat) | |
| Incubation time | 45 minutes | |
| Tissue permeability (value with units) | Measurement of number of first cup: Control:7 minutes , Test:20.2 minutes | |
| Tissue Sample | In castrated testosterone treated rats | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |