Details of TopicalPdb ID 1383
| ID | 1383 | |
| PMID | 20089796 | |
| Year | 2010 | |
| Sequence | APQIVRGASEDVRK QPYNLTIAWFRMGG | |
| Name | HSV-1 gD 77-104 (group-1) | |
| Length | 28 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | T-cell epitope peptide identified from HSV1-gD | |
| Nature of Peptide/Cargo | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | FACS | |
| Enhancer | CpG adjuvant | |
| Properties of enhancer | Not mentioned | |
| Concentration | 50 µl per nasal cavity | |
| Incubation time | Immunized on 0,14 and 21 days. Euthanized after 10 days. | |
| Tissue permeability (value with units) | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | |
| Tissue Sample | Nasal cavity of New Zealand White rabbits | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) NCC(=O)NCC=O)CCSC)CCCNC(=N)N)Cc2ccccc2) Cc2c[nH]c3c2cccc3)C)[C@H](CC)C)[C@H](O)C)CC(C)C) CC(=O)N)Cc2ccc(cc2)O)CCC)CCC(=O)N) CCCCN)CCCNC(=N)N)C(C)C)CC(=O)O)CCC(=O)O) CO)C)CCCNC(=N)N)C(C)C)[C@H](CC)C) CCC(=O)N)CCC1)C | |