PRIMARY INFORMATION |
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ID | 1272 |
PMID | 8156912 |
Year | 1994 |
Sequence | HSDAVFTDNYTRLR KQMAVKKYLNSILN |
Name | Stearyl-VIP |
Length | 28 |
N-Terminal Modification | Stearic acid fused on N-terminus by amide bond |
C-Terminal Modification | Free |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | None |
Origin of Peptide | Derivative of VIP |
Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. |
Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Radioactive assay, Measurement of E2(Erection) |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | Each rat received 30-50 µg Stearyl-VIP in about 10 µl ointment (2 g lubricant [K-Y Vaginal Lubricating Jelly], 10 mg Stearyl-VIP, 1.7 ml nitroglycerin [1 mg/ml] and 130 µl of DMSO). |
Incubation time | 45 minutes |
Tissue permeability (value with units) | Measurement of E2(Erection): Control:4 , Test:11 |
Tissue Sample | In castrated testosterone treated rats |
Ex vivo/In vivo/In vitro | in vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |