| PRIMARY INFORMATION |
|---|
| ID | 1351 |
| PMID | 1522236 |
| Year | 1992 |
| Sequence | HSDAVFTDNYTRLR
KQMAVKKYLNSILN |
| Name | Stearyl-VIP |
| Length | 28 |
| N-Terminal Modification | Stearic acid fused on N-terminus by amide bond |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | Derivative of VIP |
| Nature of Peptide/Cargo | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. |
| Mechanism | VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Labelled peptide was detected and quantified by measuring radioactivity in a gamma counter |
| Enhancer | Before testing, each male was put in a separate cage for around one hour, then introduced to a receptive female, their mounts plus intromissions were recorded over a period of 15 min. |
| Properties of enhancer | Not mentioned |
| Concentration | 20 µl saline solution of 1 µg/ml experimental drug mixed with 10 µl DMSO and directly applied on the sex organ |
| Incubation time | 60 minutes |
| Tissue permeability (value with units) | 1.25% of the applied material was found in the penile tissue |
| Tissue Sample | Rats with reduced sexual potential due to castration were employed for topical application on their penile organ. |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
