Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1013 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1014 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1015 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1076 | SequenceRRRRRRRR | NamePolyarginine | Nature of peptide or cargoCell penetrating peptide | AssayFranz cell system | Tissue permeabilityThe SC, epidermal and dermal retention of SP for SP-NLC-R11 was 10.92, 7.02 and 0.82 mg/g of skin, respectively and the SC, epidermal and dermal retention of KP for KP-NLC-R11 was 0.75, 0.44 and 0.17 mg/g of skin, respectively | Tissue SampleSkin from the dorsal surface of hairless rat | PUBMED ID22617521 |
| ID1091 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoTat-SOD is anti-inflammatory | AssayHistochemical analysis | Tissue permeabilitySignificant permeability of the Tat-SOD peptide can be seen in histochemical images | Tissue SampleEar of mice | PUBMED ID22189681 |
| ID1092 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayFranz diffusion cells, HPLC | Tissue permeabilityPermeation parameters observed were 15.74 ± 1.31% | Tissue SampleDorsal skin of mice | PUBMED ID22072881 |
| ID1093 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayFranz diffusion cells, HPLC | Tissue permeabilityPermeation parameters observed were5.74 ± 1.32% | Tissue SampleDorsal skin of mice | PUBMED ID22072881 |
| ID1094 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayIn vivo therapeutic efficacy assay | Tissue permeabilityShow significantly improvement in wound and dry skin | Tissue SamplePostaxial back skin of the mice | PUBMED ID22072881 |
| ID1095 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayIn vivo therapeutic efficacy assay | Tissue permeabilityShow significantly improvement in wound and dry skin but lesser than EL/T | Tissue SamplePostaxial back skin of the mice | PUBMED ID22072881 |
| ID1103 | SequenceCGLHPAFQC | NameTDA1 | Nature of peptide or cargoAnti-obesity treatment, Adipose tissue-targeting property and transdermal capacity | AssayFranz cell system | Tissue permeabilityAppearing frequency in the analyzed peptide pool (%) 28/280 (10) | Tissue SampleAbdominal skin surface of male wistar rats | PUBMED ID21999821 |
| ID1117 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability64.9±8.8% degraded | Tissue SampleInterior skin surface of dermatomed skin (DS) of porcine | PUBMED ID19486932 |
| ID1118 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability15±4.1% degraded | Tissue SampleInterior skin surface of heat separated epidermis (HSE) of porcine | PUBMED ID19486932 |
| ID1119 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability100% degraded | Tissue SampleInterior skin surface of full thickness skin (FTS) of porcine | PUBMED ID19486932 |
| ID1120 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability87.8±4.4% degraded | Tissue SampleInterior skin surface of dermatomed skin (DS) of porcine | PUBMED ID19486932 |
| ID1121 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability51.3±6% degraded | Tissue SampleInterior skin surface of heat separated epidermis (HSE) of porcine | PUBMED ID19486932 |
| ID1143 | Sequencer–nle–nle–nle–r–nle–nle–nle–g–y | NameRDP58 | Nature of peptide or cargoImmunomodulator | AssayHistological assay using bright field microscopy | Tissue permeabilityIt can be clearly seen from the histological images that topical application of RDP58results in significant decrease in tthe hickness of the ear skin as compared to control (TPA applied ear skin) | Tissue SampleEar of mice | PUBMED ID16117788 |
| ID1145 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 210 spots/1*106 total cells(4 folds more than the permeability of the peptide with vehicle alone) | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1146 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 65 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1147 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 51 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1148 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 100 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1149 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 200 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1150 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 215 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1151 | SequenceSIINFEKL | NameOVA257–264 | Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | AssayELISPOT assay | Tissue permeability~ 65 spots/1*106 total cells | Tissue SampleEpidermal layer of naive C57BL mice | PUBMED ID16113599 |
| ID1194 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability10 ng/ml serum conc. of desmopressin after ~100 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1195 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability1 ng/ml serum conc. of desmopressin after ~250 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1196 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability0.8 ng/ml serum conc. of desmopressin after ~350 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1197 | SequenceSIINFEKL | NameOVA8 | Nature of peptide or cargoOVA8 peptides can be used to detect a strong CD8+ cytolytic T cell response | AssayHistochemical staining | Tissue permeabilityDistributed uniformly on the skin surface without obvious penetration into deeper layers of the epidermis or the dermis. | Tissue SampleTape-stripped ears of mice | PUBMED ID15121311 |
| ID1199 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 2.37 ± 0.94 µg h−1 cm−2 at 100% DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1200 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 9.87 ± 4.91 µg h−1 cm−2 at 75% pulsed DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1201 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 5.57 ± 2.27 µg h−1 cm−2 at 50% pulsed DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1202 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 1.21 ± 0.76 µg h−1 cm−2 at 75%+/25%− AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1203 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 0.006 ± 0.004 µg h−1 cm−2 at 50%+/50%− AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1204 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 1.99 ± 2.04 µg h−1 cm−2 at 100% DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1205 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 6.47 ± 0.87 µg h−1 cm−2 at 75% DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1206 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 0.96 ± 0.79 µg h−1 cm−2 at 50% pulsed DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1207 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 3.33 ± 1.04 µg h−1 cm−2 at 75%+/25%- AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1208 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 0.15 ± 0.09 µg h−1 cm−2 at 50%+/50%- AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1209 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 12.39 ± 5.32 µg h−1 cm−2 at 75% pulsed DC (500 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1210 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 5.97 ± 3.20 µg h−1 cm−2 at 50% pulsed DC (500 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1211 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux=9.07 ± 4.28 µg h−1 cm−2 at 25% pulsed DC (500 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1212 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 8.70±3.56 µg h−1 cm−2 at 75% pulsed DC (5 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1213 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 7.31±1.94 µg h−1 cm−2 at 50% pulsed DC (5 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1214 | SequencepGlu-HWSYGLRPG | NameLHRH | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityLHRH flux= 9.35±1.98 µg h−1 cm−2 at 25% pulsed DC (5 Hz) | Tissue SampleEpidermis of human cadaver skin | PUBMED ID14757511 |
| ID1259 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityAlgesic response: ~15(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1260 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityAlgesic response: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1261 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin vehicle pretreatment: ~15.3(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1262 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~10.7(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1263 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin vehicle pretreatment: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1264 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~20(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1295 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.03)/Treated(1.72 ± 0.20), PGE2 levels(ng/ear)=Untreated(0)/Treated(83.2 ± 2.8), LTB4 levels(ng/ear)=Untreated(0)/Treated(15.2 ± 1.2) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |