ID | 1261 | |
PMID | 8443036 | |
Year | 1994 | |
Sequence | KRPPGFSPFR | |
Name | Kallidin | |
Length | 10 | |
N-Terminal Modification | Free | |
C-Terminal Modification | Free | |
Linear/ Cyclic | Linear | |
Chirality | L | |
Chemical Modification | None | |
Origin of Peptide | Synthetic | |
Nature of Peptide/Cargo | Potent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | |
Mechanism | Not mentioned | |
Cargo Sequence/Structure | None | |
Name of cargo | Not applicable | |
Assay | Painful sensation assessed in a visual analogue scale(VAS) | |
Enhancer | None | |
Properties of enhancer | Not applicable | |
Concentration | 50µl of 50 nmol Kallidin was diluted in 0.9% saline | |
Incubation time | At various time intervals(30 seconds and each minute for 10 minutes) | |
Tissue permeability (value with units) | Pain response obtained in nostrils after capsaicin vehicle pretreatment: ~15.3(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | |
Tissue Sample | Solution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | |
Ex vivo/In vivo/In vitro | in vivo | |
STRUCTURE |
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SMILES | N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O) N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C (=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)CO |