| PRIMARY INFORMATION |
|---|
| ID | 1207 |
| PMID | 14757511 |
| Year | 2004 |
| Sequence | pGlu-HWSY-D-2-Nal-LRPG |
| Name | Nafarelin |
| Length | 10 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Cyclic |
| Chirality | Mix |
| Chemical Modification | pGlu= Pyroglutamic acid, Nal=Naphthylalanine |
| Origin of Peptide | Synthetic |
| Nature of Peptide/Cargo | Peptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. |
| Mechanism | Major mechanism of iontophoretic transdermal delivery of large peptides is the convective solvent flow. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | HPLC |
| Enhancer | Transdermal iontophoresis |
| Properties of enhancer | Transdermal iontophoresis utilizes low current/voltage electrostatic repulsion and electroosmotic solvent flow |
| Concentration | 0.5 mM of peptide in a buffer which consisted of 25 mM Hepes and 150 mM NaCl (pH 7.4) |
| Incubation time | Iontophoretic experiments lasted for 12 h |
| Tissue permeability (value with units) | Nafarelin flux= 3.33 ± 1.04 µg h−1 cm−2 at 75%+/25%- AC |
| Tissue Sample | Human cadaver skin |
| Ex vivo/In vivo/In vitro | ex vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
