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Details of TopicalPdb ID 1263

PRIMARY INFORMATION
ID1263
PMID8443036
Year1998
SequenceKRPPGFSPFR
NameKallidin
Length10
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayPainful sensation assessed in a visual analogue scale(VAS)
EnhancerNone
Properties of enhancerNot applicable
Concentration50µl of 500 nmol Kallidin was diluted in 0.9% saline
Incubation timeAt various time intervals(30 seconds and each minute for 10 minutes)
Tissue permeability (value with units)Pain response obtained in nostrils after capsaicin vehicle pretreatment: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value.
Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N1CCC[C@H]1C(=O)
N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C
(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)CO