Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1245 | SequencepGlu-HP | NameThyrotropin-releasing hormone (TRH) | Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND) | AssayRadioimmunoassay and Liquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)= 18.4*105 cm/h, Cumulative amount= 24.9± 1.7 µg/cm2, Enhancement factor (EF) =3.4 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1246 | SequencepGlu-HP | NameThyrotropin-releasing hormone (TRH) | Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND) | AssayRadioimmunoassay and Liquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)= 16.6*105 cm/h, Cumulative amount= 18.5± 2.1 µg/cm2, Enhancement factor (EF) =3.1 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1247 | SequencepGlu-HP | NameThyrotropin-releasing hormone (TRH) | Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND) | AssayRadioimmunoassay and Liquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)= 5.4*105 cm/h, Cumulative amount= 7.8± 1.7 µg/cm2, Enhancement factor (EF) =0 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1248 | SequencepGlu-3-methyl-HP | NameM-TRH | Nature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide. | AssayLiquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)= 32.0*105 cm/h, Cumulative amount= 41.5±4.9 µg/cm2, Enhancement factor (EF) =4.7 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1249 | SequencepGlu-3-methyl-HP | NameM-TRH | Nature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide. | AssayLiquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)=20.2*105 cm/h, Cumulative amount= 20.4± 3.6µg/cm2, Enhancement factor (EF) =3.0 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1250 | SequencepGlu-3-methyl-HP | NameM-TRH | Nature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide. | AssayLiquid Scintillation Technique | Tissue permeabilityPermeability coefficient (Kp)= 6.8*105 cm/h, Cumulative amount= 8.6± 1.0 µg/cm2, Enhancement factor (EF) =0 | Tissue SampleHuman epidermal membrane | PUBMED ID10205635 |
| ID1251 | SequenceTPRL | NameCarboranyl pseudotetrapeptide analogue of the insect pyrokinin/PBAN neuropeptide family | Nature of peptide or cargoPotent pheromonotropic/myotropic activity | AssayCockroach Myotropic Bioassay and Pheromonotropic Assay (Topical) | Tissue permeability~ 23 ng/female, ED50=25pmol, Maximal response=60pmol | Tissue SampleAfter the scales were removed, 1µl of peptide solution was applied to the surface of the cuticle and smoothed evenly over the prepared surface | PUBMED ID8844762 |
| ID1252 | SequenceTPRL | NameCarboranyl pseudotetrapeptide analogue of the insect pyrokinin/PBAN neuropeptide family | Nature of peptide or cargoPotent pheromonotropic/myotropic activity | AssayCockroach Myotropic Bioassay and Pheromonotropic Assay (Topical) | Tissue permeability~ 62 ng/female, ED50=25pmol, Maximal response=60pmol | Tissue SampleAfter the scales were removed, 1µl of peptide solution was applied to the surface of the cuticle and smoothed evenly over the prepared surface | PUBMED ID8844762 |
| ID1253 | SequenceTPRL | NameCarboranyl pseudotetrapeptide analogue of the insect pyrokinin/PBAN neuropeptide family | Nature of peptide or cargoPotent pheromonotropic/myotropic activity | AssayCockroach Myotropic Bioassay and Pheromonotropic Assay (Topical) | Tissue permeability~ 70 ng/female, ED50=25pmol, Maximal response=60pmol | Tissue SampleAfter the scales were removed, 1µl of peptide solution was applied to the surface of the cuticle and smoothed evenly over the prepared surface | PUBMED ID8844762 |
| ID1254 | SequenceVTHRLAGLLSRSGGM VKSNFVPTNVGSKAF | NameCGRP receptor antagonist CGRP(8-37) | Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodelling | AssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test. | Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~24.5 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~36.5 mm2). | Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats. | PUBMED ID8584255 |
| ID1255 | SequenceVTHRLAGLLSRSGGM VKSNFVPTNVGSKAF | NameCGRP receptor antagonist CGRP(8-37) | Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodelling | AssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test. | Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~17 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~25 mm2). | Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats. | PUBMED ID8584255 |
| ID1256 | SequenceVTHRLAGLLSRSGGM VKSNFVPTNVGSKAF | NameCGRP receptor antagonist CGRP(8-37) | Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodelling | AssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test. | Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~13 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~16.5 mm2). | Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats. | PUBMED ID8584255 |
| ID1257 | SequenceVTHRLAGLLSRSGGM VKSNFVPTNVGSKAF | NameCGRP receptor antagonist CGRP(8-37) | Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodelling | AssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test. | Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~12 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~14 mm2). | Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats. | PUBMED ID8584255 |
| ID1258 | SequenceVTHRLAGLLSRSGGM VKSNFVPTNVGSKAF | NameCGRP receptor antagonist CGRP(8-37) | Nature of peptide or cargoRegulation of blood flow, modulation of inflammation, and tissue remodelling | AssayPhotographed both hind paws using a micro-computer imaging device(MCID)-assessed analysis system. Immunostaining. Mann-Whitney U-test. | Tissue permeabilityEffect of the CGRP-receptor antagonist CGRP(8-37)(~7 mm2) on the necrotic area in UV-damaged skin of the rat hindpaw compared to solvent applications(~13.5 mm2). | Tissue SampleThe dorsum of both hind paws were irradiated of male Sprague-Dawley (SD) rats. | PUBMED ID8584255 |
| ID1262 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~10.7(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1263 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin vehicle pretreatment: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1264 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin pretreatment((50 nmol in 50 µl, everyday for 5-7 days): ~20(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1295 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.03)/Treated(1.72 ± 0.20), PGE2 levels(ng/ear)=Untreated(0)/Treated(83.2 ± 2.8), LTB4 levels(ng/ear)=Untreated(0)/Treated(15.2 ± 1.2) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1296 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.03)/Treated(1.73 ± 0.13), PGE2 levels(ng/ear)=Untreated(0)/Treated(79.2 ± 3.1), LTB4 levels(ng/ear)=Untreated(0)/Treated(17.6 ± 1.3) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1297 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.03)/Treated(1.68 ± 0.21), PGE2 levels(ng/ear)=Untreated(0)/Treated(80.1 ± 3.2), LTB4 levels(ng/ear)=Untreated(0)/Treated(18.1 ± 2.2) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1298 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.02)/Treated(48.2 ± 3.2), NAG levels(mU/ear)=Untreated(23.1 ± 1.1)/Treated(39.1 ± 3.1), 6-keto-PGF1α(pg/ear)=Untreated(198 ± 22)/Treated(381 ± 31), LTB4 levels(pg/ear)=Untreated(0.30)/Treated(893 ± 161) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1299 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.02)/Treated(42.7 ± 3.1), NAG levels(mU/ear)=Untreated(23.1 ± 1.1)/Treated(30.9 ± 2.9), 6-keto-PGF1α(pg/ear)=Untreated(198 ± 22)/Treated(Not defined), LTB4 levels(pg/ear)=Untreated(0.30)/Treated(697 ± 131) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1300 | SequenceHDMNKVLDL | NameNonapeptide P2 or AF-2 | Nature of peptide or cargoShowed an anti-inflammatory effect in carrageenan-induced rat paw oedema, they inhibit pancreatic and Naja naja PLA2 in vitro and acute inflammatory processes induced by carrageenan or phorbol esters when administered locally or parenterally. | AssayMPO and NAG assays | Tissue permeabilityMPO levels(mU/ear)=Untreated(0.02)/Treated(38.2 ± 2.5), NAG levels(mU/ear)=Untreated(23.1 ± 1.1)/Treated(27.1 ± 2.6), 6-keto-PGF1α(pg/ear)=Untreated(198 ± 22)/Treated(254 ± 26), LTB4 levels(pg/ear)=Untreated(0.30)/Treated(523 ± 128) | Tissue SampleEar(auditory pinna) of male Swiss Webster mice | PUBMED ID7646536 |
| ID1393 | SequenceT | NameCapsaicin | Nature of peptide or cargoRepeated capsaicin applications are assumed to cause desensitization of the nasal mucosa and a decreased secretory response | AssayImmunocytochemistry, electron microscopy | Tissue permeabilityThe number of goblet cells was increased in the nasal region. CGRP-Iike activity was decreased in biopsies taken from the test sides of the paranasal sinuses when compared to control. | Tissue SampleNasal mucosa of New Zealand White rabbits | PUBMED ID8737771 |
| ID1394 | SequenceRPPGFSPFR | NameBradykinin | Nature of peptide or cargoSmall endogenous peptide mediators formed de novo at sites of tissue damage where it has important actions that contribute to the acute inflammatory response. | AssayEvan's blue dye | Tissue permeabilityInstillation of bradykinin increased extravasation of Evans blue dye to 93.5±7.5 ng/ml from baseline 8.54±0.93 ng/ml | Tissue SampleNasal mucosa of guinea pigs | PUBMED ID8719791 |
| ID1397 | SequenceBotulinum neurotoxin A light chain (PFVNKQF NYKDPVNGVDIAYIKIPN AGQMQPVKAFKIHNKI WVIPERDTFTNPEEGD LNPPPEAKQVPVSYY DSTYLSTDNEKDNYLK GVTKLFERIYSTDLGR MLLTSIVRGIPFWGG STIDTELKVIDTNCIN VIQPDGSYRSEE LNLVIIGPSADIIQFE CKSFGHEVLNLTRNGY GSTQYIRFSPDFT FGFEESLEVDTNPLL | NameBotulinum toxin type A | Nature of peptide or cargoPotent inhibitor of cholinergic motor nerves. | AssayWeights of the nasal secretion were collected and compared. | Tissue permeabilityTopically applied botulinum toxin reduced neurally evoked rhinorrhea by an average of 41%. | Tissue SampleNasal cavity of male mongrel dogs | PUBMED ID7700663 |
| ID1501 | SequenceDF-Me-Phe-GLM | NameSenktide | Nature of peptide or cargoNK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity. | AssayRadioimmunoassay | Tissue permeabilityThe mean maximum pupillary constriction observed with senktide (25 mg, i.v.) was 4.25+0.25 mm. | Tissue SampleEye of rabbit | PUBMED ID9351503 |