PRIMARY INFORMATION |
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ID | 1245 |
PMID | 10205635 |
Year | 1999 |
Sequence | pGlu-HP |
Name | Thyrotropin-releasing hormone (TRH) |
Length | 3 |
N-Terminal Modification | Free |
C-Terminal Modification | Amidation |
Linear/ Cyclic | Cyclic |
Chirality | L |
Chemical Modification | pGlu= Pyroglutamic acid |
Origin of Peptide | Synthetic |
Nature of Peptide/Cargo | It is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND) |
Mechanism | Not mentioned |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Radioimmunoassay and Liquid Scintillation Technique |
Enhancer | Cineole and Ethanol |
Properties of enhancer | The enhancement factors are driving force for permeation is the thermodynamic activity of the permeant in the donor solution. |
Concentration | 3% (w/w) cineole in combination with 47% ethanol (w/w) and 50% PBS (n=3) |
Incubation time | 30 h |
Tissue permeability (value with units) | Permeability coefficient (Kp)= 18.4*105 cm/h, Cumulative amount= 24.9± 1.7 µg/cm2, Enhancement factor (EF) =3.4 |
Tissue Sample | Human epidermal membrane |
Ex vivo/In vivo/In vitro | in vitro |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |