| PRIMARY INFORMATION |
|---|
| ID | 1393 |
| PMID | 8737771 |
| Year | 1996 |
| Sequence | T |
| Name | Capsaicin |
| Length | 1 |
| N-Terminal Modification | Free |
| C-Terminal Modification | 7-methyl octa-5-ene |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | OH on benzene ring of tyrosine |
| Origin of Peptide | Component of chili peppers |
| Nature of Peptide/Cargo | Repeated capsaicin applications are assumed to cause desensitization of the nasal mucosa and a decreased secretory response |
| Mechanism | Capsaicin causes neural depolarization by stimulation of a specific neural cation channel [3], and its extended use reduces the activity of nociceptor sensory neurons |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Immunocytochemistry, electron microscopy |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 30mM |
| Incubation time | 1 day |
| Tissue permeability (value with units) | The number of goblet cells was increased in the nasal region. CGRP-Iike activity was decreased in biopsies taken from the test sides of the paranasal sinuses when compared to control. |
| Tissue Sample | Nasal mucosa of New Zealand White rabbits |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
