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Details of TopicalPdb ID 1252

PRIMARY INFORMATION
ID1252
PMID8844762
Year1996
SequenceTPRL
NameCarboranyl pseudotetrapeptide analogue of the insect pyrokinin/PBAN neuropeptide family
Length4
N-Terminal ModificationCbe or 2-o-carboranylethanoic acid
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoPotent pheromonotropic/myotropic activity
MechanismThe amphiphylic carboranyl analogue elicits pheromone production following topical application as it contains all the structural information necessary to fully activate pyrokinin receptors.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayCockroach Myotropic Bioassay and Pheromonotropic Assay (Topical)
EnhancerNone
Properties of enhancerNot applicable
Concentration60 pmol dissolved in 1µl of water
Incubation time60 minutes
Tissue permeability (value with units)~ 62 ng/female, ED50=25pmol, Maximal response=60pmol
Tissue SampleAfter the scales were removed, 1µl of peptide solution was applied to the surface of the cuticle and smoothed evenly over the prepared surface
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)
N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C(=O)N