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Details of TopicalPdb ID 1246

PRIMARY INFORMATION
ID1246
PMID10205635
Year1999
SequencepGlu-HP
NameThyrotropin-releasing hormone (TRH)
Length3
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicCyclic
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid
Origin of PeptideSynthetic
Nature of Peptide/CargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioimmunoassay and Liquid Scintillation Technique
EnhancerCineole and Ethanol
Properties of enhancerThe enhancement factors are driving force for permeation is the thermodynamic activity of the permeant in the donor solution.
Concentration50% (w/w) ethanol and 50% PBS (n=3)
Incubation time30 h
Tissue permeability (value with units)Permeability coefficient (Kp)= 16.6*105 cm/h, Cumulative amount= 18.5± 2.1 µg/cm2, Enhancement factor (EF) =3.1
Tissue SampleHuman epidermal membrane
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.