| PRIMARY INFORMATION |
|---|
| ID | 1248 |
| PMID | 10205635 |
| Year | 1999 |
| Sequence | pGlu-3-methyl-HP |
| Name | M-TRH |
| Length | 3 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Cyclic |
| Chirality | L |
| Chemical Modification | pGlu= Pyroglutamic acid |
| Origin of Peptide | Analogue of TRH |
| Nature of Peptide/Cargo | Analogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide. |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Liquid Scintillation Technique |
| Enhancer | Cineole and Ethanol |
| Properties of enhancer | The enhancement factors are driving force for permeation is the thermodynamic activity of the permeant in the donor solution. |
| Concentration | 5 mg/ml of M-TRH in presence of 3% (w/w) cineole in combination with 47% ethanol (w/w) and 50% PBS (n=3) |
| Incubation time | 30 h |
| Tissue permeability (value with units) | Permeability coefficient (Kp)= 32.0*105 cm/h, Cumulative amount= 41.5±4.9 µg/cm2, Enhancement factor (EF) =4.7 |
| Tissue Sample | Human epidermal membrane |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
