| ID | 1397 | |
| PMID | 7700663 | |
| Year | 1995 | |
| Sequence | Botulinum neurotoxin A light chain (PFVNKQF NYKDPVNGVDIAYIKIPN AGQMQPVKAFKIHNKI WVIPERDTFTNPEEGD LNPPPEAKQVPVSYY DSTYLSTDNEKDNYLK GVTKLFERIYSTDLGR MLLTSIVRGIPFWGG STIDTELKVIDTNCIN VIQPDGSYRSEE LNLVIIGPSADIIQFE CKSFGHEVLNLTRNGY GSTQYIRFSPDFT FGFEESLEVDTNPLL | |
| Name | Botulinum toxin type A | |
| Length | 1295 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Cyclic (C429-453, C1234-1279) | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Neurotoxic protein produced by the bacterium Clostridium botulinum. It is also produced commercially for medical, cosmetic and research use. | |
| Nature of Peptide/Cargo | Potent inhibitor of cholinergic motor nerves. | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Weights of the nasal secretion were collected and compared. | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | 50 units of type A botulinum toxin (total volume 4 cm 3,conc 1.25 units/0.1 cm) | |
| Incubation time | 6 days | |
| Tissue permeability (value with units) | Topically applied botulinum toxin reduced neurally evoked rhinorrhea by an average of 41%. | |
| Tissue Sample | Nasal cavity of male mongrel dogs | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |