Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0551Heat-shock proteins 60

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Host (Endogenous) (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalInduces the expression of TNF-‚ç∫Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206899292010NA
PRRID_0551Heat-shock proteins 60

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Host (Endogenous) (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalInduces the expression of TNF-‚ç∫Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206899292010NA
PRRID_0554hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio vulnificus (Bacteria)MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY4595ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacropahesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0554hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio vulnificus (Bacteria)MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY4595ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacropahesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0555hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio cholerae (Bacteria)MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL4558ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0555hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio cholerae (Bacteria)MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL4558ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0559HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0559HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0560HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0560HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0561HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageRAGEReceptor for advanced glycation endproducts (RAGE)MiceNALeucine-rich Repeat (LRR) DomainQ62151.fastaQ62151402Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0561HMGB1

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Mouse model of endotoxemiaMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalActs as a mediator of inflammation and organ damageRAGEReceptor for advanced glycation endproducts (RAGE)MiceNALeucine-rich Repeat (LRR) DomainQ62151.fastaQ62151402Acts as a mediator of inflammation and organ damageNA207403412010Pubchem Assay
PRRID_0562HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalIt interacts with the TLR4 and elicit immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatEndothelial cellsLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835It induced vascular endothelial activationEMSA207147912010Pubchem Assay
PRRID_0562HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalIt interacts with the TLR4 and elicit immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)RatEndothelial cellsLeucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835It induced vascular endothelial activationEMSA207147912010Pubchem Assay
PRRID_0563HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalEpinephrine directly acts through Mφ β- adrenergic receptor to stimulate HMGB1 secretion from the Mφ in an autocrine mannerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicelungLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207066582010Pubchem Assay
PRRID_0563HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalEpinephrine directly acts through Mφ β- adrenergic receptor to stimulate HMGB1 secretion from the Mφ in an autocrine mannerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicelungLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207066582010Pubchem Assay
PRRID_0564HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalinduced cellular activation and NF-κB-dependent transcriptionToll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainNANANAIt generate the inflammatory response similar to intiated by LPSNA206899292010NA
PRRID_0564HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalinduced cellular activation and NF-κB-dependent transcriptionToll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainNANANAIt generate the inflammatory response similar to intiated by LPSNA206899292010NA
PRRID_0567HSP72

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Host (Endogenous) (others)NANAProteinNaturalincreases in MIP-2 releaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicehepatocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA206899292010Pubchem Assay
PRRID_0567HSP72

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Host (Endogenous) (others)NANAProteinNaturalincreases in MIP-2 releaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicehepatocytesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA206899292010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0677MAVS

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NANANAProteinNaturalTheir bining activate the caspase-1 platformNod-like receptor X1 (NLRX1)NOD-like receptor (NLR)NAMitochondriaNANANANAIt suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS)NA206054292010NA
PRRID_0677MAVS

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NANANAProteinNaturalTheir bining activate the caspase-1 platformNod-like receptor X1 (NLRX1)NOD-like receptor (NLR)NAMitochondriaNANANANAIt suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS)NA206054292010NA
PRRID_0684MOMP

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Shigella flexneri (Bacteria)NANAProteinNaturalIt stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES)Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUN7.fastaQ9QUN7784It initiates event in the antibacterial host response.ELISA203474872010Pubchem Assay
PRRID_0684MOMP

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Shigella flexneri (Bacteria)NANAProteinNaturalIt stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES)Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUN7.fastaQ9QUN7784It initiates event in the antibacterial host response.ELISA203474872010Pubchem Assay
PRRID_0696mutated SOD1

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exogenous (others)NANAProteinSyntheticNAToll-like receptor 14 (TLR14)Toll-like receptor (TLR)MicemicrogliaNAP10810.fastaP10810366activation and toxicity of microgliaNA207066422010Pubchem Assay
PRRID_0696mutated SOD1

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exogenous (others)NANAProteinSyntheticNAToll-like receptor 14 (TLR14)Toll-like receptor (TLR)MicemicrogliaNAP10810.fastaP10810366activation and toxicity of microgliaNA207066422010Pubchem Assay
PRRID_0697MxiI

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Shigella flexneri (Bacteria)MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS97ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0697MxiI

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Shigella flexneri (Bacteria)MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS97ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0699N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress IRF3 activation (Bind to TBK1)The class II transactivator (CIITA)NOD-like receptor (NLR)HumanNALeucine-rich Repeat (LRR) DomainP33076.fastaP330761130Suppress IFN productionNA206720472010Pubchem Assay
PRRID_0699N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress IRF3 activation (Bind to TBK1)The class II transactivator (CIITA)NOD-like receptor (NLR)HumanNALeucine-rich Repeat (LRR) DomainP33076.fastaP330761130Suppress IFN productionNA206720472010Pubchem Assay
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0708Non-Structural Proetein 3 (NS3)

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Hepatitis C Virus (virus)AGARLVVLATATPPGSVTVPHPNIQEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLSSLGLNAVAYYRGLD84ProteinNaturalIt binds to the SRA-1 and activates the downstream cascadeScavenger receptor A-1 (SR A-1)Scavenger receptor (SR)Chinese HamsterOvary cellsNANANANAIt has a role in NS3 uptake and cross-presentation.ELISA203386592010NA
PRRID_0708Non-Structural Proetein 3 (NS3)

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Hepatitis C Virus (virus)AGARLVVLATATPPGSVTVPHPNIQEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLSSLGLNAVAYYRGLD84ProteinNaturalIt binds to the SRA-1 and activates the downstream cascadeScavenger receptor A-1 (SR A-1)Scavenger receptor (SR)Chinese HamsterOvary cellsNANANANAIt has a role in NS3 uptake and cross-presentation.ELISA203386592010NA
PRRID_0709Non-Structural Proetein 3 (NS3)

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Hepatitis C Virus (virus)AGARLVVLATATPPGSVTVPHPNIQEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLSSLGLNAVAYYRGLD84ProteinNaturalIt binds to the SREC-1 and activates the downstream cascadeScavenger receptor A-1 (SR A-1)Scavenger receptor (SR)Chinese HamsterOvary cellsNANANANAIt has a role in NS3 uptake and cross-presentation.ELISA203386592010NA
PRRID_0709Non-Structural Proetein 3 (NS3)

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Hepatitis C Virus (virus)AGARLVVLATATPPGSVTVPHPNIQEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLSSLGLNAVAYYRGLD84ProteinNaturalIt binds to the SREC-1 and activates the downstream cascadeScavenger receptor A-1 (SR A-1)Scavenger receptor (SR)Chinese HamsterOvary cellsNANANANAIt has a role in NS3 uptake and cross-presentation.ELISA203386592010NA
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0748phenol-soluble modulin

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Staphylococcus epidermis (Bacteria)MSKLAEAIANTVKAAQDQDWTKLGTSIVDIVESGVSVLGKIFGF44ProteinNaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0748phenol-soluble modulin

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Staphylococcus epidermis (Bacteria)MSKLAEAIANTVKAAQDQDWTKLGTSIVDIVESGVSVLGKIFGF44ProteinNaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0750Phosphoprotein

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Measles virus (virus)MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSGTPIKKGTERRLASFGTEIASLLTGGATQCARKSPSEPSGPGAPAGNVPEYVSNAALIQEWTPESGTTISPRSQNNEEGGDYYDDELFSDVQDIKTALAKIHEDNQKIISKLESLLLLKGEVESIKKQINRQNISISTLEGHLSSIMIAIPGLGKDPNDPTADVEINPDLKPIIGRDSGRALAEVLKKPVASRQLQGMTNGRTSSRGQLLKEFQPKPIGKKMSSAVGFVPDTGPASRSVIRSIIKSSRLEEDRKRYLMTLLDDIKGANDLAKFHQMLMKIIMK507ProteinNaturalSuppress NF-κB and AP-1 activation (Upregulate host NF-κB negative regulator A20)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit proinflammatory cytokine and chemokine productionNA206720472010NA
PRRID_0750Phosphoprotein

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Measles virus (virus)MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSGTPIKKGTERRLASFGTEIASLLTGGATQCARKSPSEPSGPGAPAGNVPEYVSNAALIQEWTPESGTTISPRSQNNEEGGDYYDDELFSDVQDIKTALAKIHEDNQKIISKLESLLLLKGEVESIKKQINRQNISISTLEGHLSSIMIAIPGLGKDPNDPTADVEINPDLKPIIGRDSGRALAEVLKKPVASRQLQGMTNGRTSSRGQLLKEFQPKPIGKKMSSAVGFVPDTGPASRSVIRSIIKSSRLEEDRKRYLMTLLDDIKGANDLAKFHQMLMKIIMK507ProteinNaturalSuppress NF-κB and AP-1 activation (Upregulate host NF-κB negative regulator A20)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit proinflammatory cytokine and chemokine productionNA206720472010NA
PRRID_0775Pore-forming toxins

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Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)NANAProteinNaturalActivates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance.Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)NOD-like receptor (NLR)NANAQ9C000.fastaQ9C0001473It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0775Pore-forming toxins

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Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)NANAProteinNaturalActivates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance.Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)NOD-like receptor (NLR)NANAQ9C000.fastaQ9C0001473It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0776Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206794452010NA
PRRID_0776Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206794452010NA
PRRID_0777PrgJ

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S. typhimurium (Bacteria)MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS101ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0777PrgJ

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S. typhimurium (Bacteria)MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS101ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0778profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY163ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD95MDA5Rig-like receptor (RLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ53TB6.fastaQ53TB6435It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0778profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY163ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD95MDA5Rig-like receptor (RLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainQ53TB6.fastaQ53TB6435It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0780PscI

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Pseudomonas aeruginosa (Bacteria)MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ112ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0780PscI

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Pseudomonas aeruginosa (Bacteria)MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ112ProteinNaturalIt activates caspase-1 through NLRC4 and secrete IL-1βNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)MiceBone marrow–derived macrophagesNAQ3UP24.fastaQ3UP241024It leads to the clearance of the pathogen from the systemELISA201336352010Pubchem Assay
PRRID_0783RID

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Adenovirus(virus)MVTPLLLLVCLPIIYASTTFAAVSHLDTDCLPALLTYLIFTSVCCTAICSIATFFVAIFQTADYLYVRVAYYRHHPQYRNHEVATLLCLS90ProteinNaturalSuppress NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress MCP-1 and IL-8 productionNA206720472010Pubchem Assay
PRRID_0783RID

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Adenovirus(virus)MVTPLLLLVCLPIIYASTTFAAVSHLDTDCLPALLTYLIFTSVCCTAICSIATFFVAIFQTADYLYVRVAYYRHHPQYRNHEVATLLCLS90ProteinNaturalSuppress NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress MCP-1 and IL-8 productionNA206720472010Pubchem Assay
PRRID_0814T3SS

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Gram-negative bacteriaMKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR330ProteinNaturalIt activates caspase 1 dependent IL-1β and IL-18 secretion in response.Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAIt act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systemsNA203491222010NA
PRRID_0814T3SS

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Gram-negative bacteriaMKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR330ProteinNaturalIt activates caspase 1 dependent IL-1β and IL-18 secretion in response.Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAIt act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systemsNA203491222010NA
PRRID_0815T4SS

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Gram-negative bacteriaNANAProteinNaturalIt activates caspase 1 dependent IL-1β and IL-18 secretion in response.Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAIt act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systemsNA203491222010NA
PRRID_0815T4SS

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Gram-negative bacteriaNANAProteinNaturalIt activates caspase 1 dependent IL-1β and IL-18 secretion in response.Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAIt act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systemsNA203491222010NA
PRRID_0816Tat

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HIV-1 (virus)MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE86ProteinNaturalActivate NF-κB (PKR-dependent)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA206720472010NA
PRRID_0816Tat

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HIV-1 (virus)MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE86ProteinNaturalActivate NF-κB (PKR-dependent)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANANANA206720472010NA
PRRID_0823type III or IV secretion systems

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Salmonella typhimurium, Shigella flexneri, Legionella pneumophila and Pseudomonas aeruginosa (BacterNANAProteinNaturalIt’s binding to the NLRP1 leads to the activation of caspase-1,IPAFNOD-like receptor (NLR)NANANANANANAIPAF-dependent caspase-1 activation is accompanied by rapid cell deathELISA201336352010NA
PRRID_0823type III or IV secretion systems

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Salmonella typhimurium, Shigella flexneri, Legionella pneumophila and Pseudomonas aeruginosa (BacterNANAProteinNaturalIt’s binding to the NLRP1 leads to the activation of caspase-1,IPAFNOD-like receptor (NLR)NANANANANANAIPAF-dependent caspase-1 activation is accompanied by rapid cell deathELISA201336352010NA
PRRID_0839Virulence factor p60

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Listeriamonocytogenes (Bacteria)MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE529ProteinNaturalIt activates of nuclear factor kB (NF-kB) and induces proinflammatory cytokine production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUK6.fastaQ9QUK6835It provides host resistance against infection with L. monocytogenes.ELISA203377012010Pubchem Assay
PRRID_0839Virulence factor p60

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Listeriamonocytogenes (Bacteria)MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE529ProteinNaturalIt activates of nuclear factor kB (NF-kB) and induces proinflammatory cytokine production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacropahesLRRQ9QUK6.fastaQ9QUK6835It provides host resistance against infection with L. monocytogenes.ELISA203377012010Pubchem Assay
PRRID_0840Virulence factor p60

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Listeriamonocytogenes (Bacteria)MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE529ProteinNaturalIt activates of nuclear factor kB (NF-kB) and induces proinflammatory cytokine production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophage RAW264.7 cellsLRRQ9QUK6.fastaQ9QUK6835It provides host resistance against infection with L. monocytogenes.ELISA203377012010Pubchem Assay
PRRID_0840Virulence factor p60

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Listeriamonocytogenes (Bacteria)MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE529ProteinNaturalIt activates of nuclear factor kB (NF-kB) and induces proinflammatory cytokine production.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceMacrophage RAW264.7 cellsLRRQ9QUK6.fastaQ9QUK6835It provides host resistance against infection with L. monocytogenes.ELISA203377012010Pubchem Assay
PRRID_0842Vpr

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HIV-1 (virus)MEQAPEDQGPQREPHNEWTLELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGVTQQRRARNGASRS96ProteinNaturalActivate NF-κBToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAEnhance IL-6, IL-8, and IL-10 productionNA206720472010NA
PRRID_0842Vpr

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HIV-1 (virus)MEQAPEDQGPQREPHNEWTLELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGVTQQRRARNGASRS96ProteinNaturalActivate NF-κBToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAEnhance IL-6, IL-8, and IL-10 productionNA206720472010NA
PRRID_0843Vpu

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HIV-1 (virus)MQPIQIAIAALVVAIIIAIVVWSIVIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISALVEMGVEMGHHAPWDIDDL81ProteinNaturalInhibit NF-κB activation (Stabilize IκB)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0843Vpu

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HIV-1 (virus)MQPIQIAIAALVVAIIIAIVVWSIVIIEYRKILRQRKIDRLIDRLIERAEDSGNESEGEISALVEMGVEMGHHAPWDIDDL81ProteinNaturalInhibit NF-κB activation (Stabilize IκB)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0882Envelope protein

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Mouse mammary tumour virusPTSACVTYPYAILLGLPQLIDIEKRGSTFHISCSSCRLTNCLDSSAYDYAAIIVKRPPYVLLPVDIGDEPWFDDSAIQTFRYATDLIRAKRFVAAIILGISALIAIITSFAVATTALVKEMQTATFVNNLHRNVTLALSEQRIIDLKLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDFICVTPLPYNASESWERTKAHLLGIWNDNEISYNIQELTNLISDMSKQHIDTVDLSGLAQSFANGVKALNPLDWTQYFIFIGVGALLLVIVLMIFPIVFQCLAKSLDQVQSDLNVLLLKKKKGGNAAPAAGTGQVRKATEEAGL326ProteinNaturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0882Envelope protein

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Mouse mammary tumour virusPTSACVTYPYAILLGLPQLIDIEKRGSTFHISCSSCRLTNCLDSSAYDYAAIIVKRPPYVLLPVDIGDEPWFDDSAIQTFRYATDLIRAKRFVAAIILGISALIAIITSFAVATTALVKEMQTATFVNNLHRNVTLALSEQRIIDLKLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDFICVTPLPYNASESWERTKAHLLGIWNDNEISYNIQELTNLISDMSKQHIDTVDLSGLAQSFANGVKALNPLDWTQYFIFIGVGALLLVIVLMIFPIVFQCLAKSLDQVQSDLNVLLLKKKKGGNAAPAAGTGQVRKATEEAGL326ProteinNaturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0886Fimbriae H protein (FimH)

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Uropathogenic E.coli (Bacteria)MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ300ProteinNaturalstimulate the innate immune system and elicits protective responses against bacterial and viral infectionsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 miceNANAQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219450412011Pubchem Assay
PRRID_0886Fimbriae H protein (FimH)

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Uropathogenic E.coli (Bacteria)MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ300ProteinNaturalstimulate the innate immune system and elicits protective responses against bacterial and viral infectionsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 miceNANAQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219450412011Pubchem Assay
PRRID_0887Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMyeloid cells, epithelial cells, microglia, astrocytesNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219825582011Pubchem Assay
PRRID_0887Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMyeloid cells, epithelial cells, microglia, astrocytesNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219825582011Pubchem Assay
PRRID_0888Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANANANANANAIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219554432011NA
PRRID_0888Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANANANANANAIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219554432011NA
PRRID_0889Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANANANANANAIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219498662011NA
PRRID_0889Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)NANANANANANAIt stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219498662011NA
PRRID_0890Flagellin

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S. typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalelicits innate responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHuman colon adenocarcinoma intestinal epithelial cellsamino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219497732011Pubchem Assay
PRRID_0890Flagellin

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S. typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalelicits innate responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHuman colon adenocarcinoma intestinal epithelial cellsamino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA219497732011Pubchem Assay