Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1162	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1162	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1163	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1163	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1165	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1165	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1166	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1166	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1167	Zymosan Click for more detail	Various pathogens (others)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1167	Zymosan Click for more detail	Various pathogens (others)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1168	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1168	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1170	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1170	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1171	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1171	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1175	1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail	Lipid (PAMPS) (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O	NA	Fatty acid	Synthetic	genotoxic anticancer agent	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL	ELISA	24799523	2014	NA
PRRID_1175	1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail	Lipid (PAMPS) (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O	NA	Fatty acid	Synthetic	genotoxic anticancer agent	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL	ELISA	24799523	2014	NA
PRRID_1177	6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail	NA	NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1177	6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail	NA	NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1178	9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1178	9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	stimulates TLR7	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	pDCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1179	Albeit lipoproteins Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	promote pro-inflammatory cytokine responses and prime Th1 and Th17 responses.	ELISA	24810614	2014	Pubchem_assay
PRRID_1179	Albeit lipoproteins Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	promote pro-inflammatory cytokine responses and prime Th1 and Th17 responses.	ELISA	24810614	2014	Pubchem_assay
PRRID_1188	Bacterial lipoprotein Click for more detail	Francisella novicida (Bacteria)	MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT	282	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24772391	2014	Pubchem_assay
PRRID_1188	Bacterial lipoprotein Click for more detail	Francisella novicida (Bacteria)	MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT	282	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24772391	2014	Pubchem_assay
PRRID_1191	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with anti-cancer and antiviral properties	DUOX2	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1191	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with anti-cancer and antiviral properties	DUOX2	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1205	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	binding of TLR8 to its ligand stimulated cell proliferation	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1205	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	binding of TLR8 to its ligand stimulated cell proliferation	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1206	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1206	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1207	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1207	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1208	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1208	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1210	class B CpG DNA motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 21 (TLR2)	Toll-like receptor (TLR)	Chicken	Macrophages	Cell Compartment/Intracellular (ER compartment)	H9BPA7.fasta	H9BPA7	972	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1210	class B CpG DNA motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 21 (TLR2)	Toll-like receptor (TLR)	Chicken	Macrophages	Cell Compartment/Intracellular (ER compartment)	H9BPA7.fasta	H9BPA7	972	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1211	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1211	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1213	CpG motif Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1213	CpG motif Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1214	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1214	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1216	CpG ODN1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	endosomal TLR9 is crucial to promote the lupus progression.	ELISA	24719374	2014	Pubchem_assay
PRRID_1216	CpG ODN1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	endosomal TLR9 is crucial to promote the lupus progression.	ELISA	24719374	2014	Pubchem_assay
PRRID_1217	CpG ODN2216 Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	Splenocytes from these mice were found to secrete higher levels of interleukin-10 (IL-10)	ELISA	24719374	2014	Pubchem_assay
PRRID_1217	CpG ODN2216 Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3	20	Nucleic Acid	Synthetic	plays either stimulatory or protective roles in different murine lupus models	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 inbred mice	Splenocytes	intracellular	Q9NR96.fasta	Q9NR96	1032	Splenocytes from these mice were found to secrete higher levels of interleukin-10 (IL-10)	ELISA	24719374	2014	Pubchem_assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1219	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	used to enhance Th1 response, also induces high levels of the anti-inflammatory, Th2- promoting cytokine IL10, which could dampen the resulting Th1 response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q9NR96.fasta	Q9NR96	1032	leads to DC maturation, increased expression of surface co-stimulatory and MHC molecules, and enhanced antigen presentation to naiÃàve T cells	ELISA	24720881	2014	Pubchem_assay
PRRID_1219	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	used to enhance Th1 response, also induces high levels of the anti-inflammatory, Th2- promoting cytokine IL10, which could dampen the resulting Th1 response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Balb/c mice	Bone marrow derived dendritic cell (BMDC)	NA	Q9NR96.fasta	Q9NR96	1032	leads to DC maturation, increased expression of surface co-stimulatory and MHC molecules, and enhanced antigen presentation to naiÃàve T cells	ELISA	24720881	2014	Pubchem_assay
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1224	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1224	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1226	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	improve cell survival, prevent cell apoptosis, attenuate cardiac dysfunction after I/R19, and improve outcome in shock induced by polymicrobial sepsis or trauma hemorrhage	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	endosomes and endoplasmic reticulum	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	In situ apoptosis assay	24721797	2014	Pubchem_assay
PRRID_1226	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	improve cell survival, prevent cell apoptosis, attenuate cardiac dysfunction after I/R19, and improve outcome in shock induced by polymicrobial sepsis or trauma hemorrhage	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	endosomes and endoplasmic reticulum	Intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	In situ apoptosis assay	24721797	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1229	Defensins Click for more detail	Host (Endogenous) (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1229	Defensins Click for more detail	Host (Endogenous) (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1230	Defensins Click for more detail	Host (Endogenous) (others)	MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	68	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1230	Defensins Click for more detail	Host (Endogenous) (others)	MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	68	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1231	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9QUN7.fasta	Q9QUN7	784	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1231	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9QUN7.fasta	Q9QUN7	784	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1232	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9QUK6.fasta	Q9QUK6	835	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1232	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9QUK6.fasta	Q9QUK6	835	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1233	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1233	dextran sodium sulphate and radiation Click for more detail	NA	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	control intestinal epithelial homeostasis and provide protection from injury	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	NA	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1234	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1234	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1235	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1235	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1236	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9EPW9.fasta	Q9EPW9	795	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1236	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9EPW9.fasta	Q9EPW9	795	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1237	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1237	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1238	Diacylated lipoprotein Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, mast cells and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9EPW9.fasta	Q9EPW9	795	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1238	Diacylated lipoprotein Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, mast cells and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9EPW9.fasta	Q9EPW9	795	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay

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