Detailed description page of PRRDB2.0

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PRRID_1206 details
Primary information
PRRIDPRRID_1206
Ligand NameCL075
SourceThiazoloquinoline compound (others)
Sequence of ligandCCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N
LengthNA
TypePattern-associated molecular patterns (PAMPs)
OccurenceSynthetic
Role of Ligandstimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12
Name of receptorToll-like receptor 7/8 (TLR7/8)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationdendritic cells, macrophages, natural killer cells
Domaincell compartment
Sequence of ReceptorNA
Swiss prot IDNA
Length Of ReceptorNA
Functionimportant role in the immune response to viral infection
Assay usedELISA
PMID24771328
Year of Publication2014
Pubchem assayNA
Primary information
PRRIDPRRID_1206
Ligand NameCL075
SourceThiazoloquinoline compound (others)
Sequence of ligandCCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N
LengthNA
TypePattern-associated molecular patterns (PAMPs)
OccurenceSynthetic
Role of Ligandstimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12
Name of receptorToll-like receptor 7/8 (TLR7/8)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationdendritic cells, macrophages, natural killer cells
Domaincell compartment
Sequence of ReceptorNA
Swiss prot IDNA
Length Of ReceptorNA
Functionimportant role in the immune response to viral infection
Assay usedELISA
PMID24771328
Year of Publication2014
Pubchem assayNA