Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0258	Lipoprotein Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0258	Lipoprotein Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0259	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0259	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0260	N-ALP1 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0260	N-ALP1 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0261	N-ALP2 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0261	N-ALP2 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0275	Chlamydia trachomatis Click for more detail	Chlamydia trachomatis(Bacteria)	NA	NA	Whole organism	Natural	Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8.	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HeLa 229 epithelial cells	LRR	Q9Y239.fasta	Q9Y239	953	NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection.	ELISA	18426885	2008	Pubchem Assay
PRRID_0275	Chlamydia trachomatis Click for more detail	Chlamydia trachomatis(Bacteria)	NA	NA	Whole organism	Natural	Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8.	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	HeLa 229 epithelial cells	LRR	Q9Y239.fasta	Q9Y239	953	NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection.	ELISA	18426885	2008	Pubchem Assay
PRRID_0280	Curdlan Click for more detail	Alcaligenes faecalis(Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.	Dectin-1	C type Lectin (CTL/CLR)	Human	PBMCs and monocyte-derived macrophages.	NA	Q9BXN2.fasta	Q9BXN2	247	It is resoonsible for the immuno-inflammation in the host cell.	ELISA	18549457	2008	Pubchem Assay
PRRID_0280	Curdlan Click for more detail	Alcaligenes faecalis(Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Curdlan is a pure dectin-1 agonist and induces TNF-alpha production in human PBMCs and macrophages.	Dectin-1	C type Lectin (CTL/CLR)	Human	PBMCs and monocyte-derived macrophages.	NA	Q9BXN2.fasta	Q9BXN2	247	It is resoonsible for the immuno-inflammation in the host cell.	ELISA	18549457	2008	Pubchem Assay
PRRID_0282	E. coli Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Protein	Natural	NA	GNBP4	Gram-negative Bacteria-binding Protein (GNBPs)	Mosquito	midgut epithelium	NA	NA	NA	NA	GNBPB4 in the IMD pathway. The IMD pathway has been shown to regulate anti-Plasmodium defence	Bacterial and Plasmodium infection assays	18237283	2008	NA
PRRID_0282	E. coli Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Protein	Natural	NA	GNBP4	Gram-negative Bacteria-binding Protein (GNBPs)	Mosquito	midgut epithelium	NA	NA	NA	NA	GNBPB4 in the IMD pathway. The IMD pathway has been shown to regulate anti-Plasmodium defence	Bacterial and Plasmodium infection assays	18237283	2008	NA
PRRID_0283	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole organism	Natural	BbFREP is able to bind bacteria E. coli.	BbFREP	Multivalent Pattern recognition receptor (PRR)	Amphioxus (Branchiostoma belcheri)	hepatic caecum	fibrinogen-like (FBG) domain	NA	NA	NA	It is repsonsible for antibacterial activity of Branchiostoma belcheri recombinant FREP against E. coli.	ELISA	18533266	2008	NA
PRRID_0283	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole organism	Natural	BbFREP is able to bind bacteria E. coli.	BbFREP	Multivalent Pattern recognition receptor (PRR)	Amphioxus (Branchiostoma belcheri)	hepatic caecum	fibrinogen-like (FBG) domain	NA	NA	NA	It is repsonsible for antibacterial activity of Branchiostoma belcheri recombinant FREP against E. coli.	ELISA	18533266	2008	NA
PRRID_0284	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	nonhemopoietic (radioresistant) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0284	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	nonhemopoietic (radioresistant) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0285	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	hemopoietic (radiosensitive) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0285	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	hemopoietic (radiosensitive) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0286	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	CF Patients	Airway epithelial cells and primary PBMCs	LRR	O60602.fasta	O60602	858	Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect.	ELISA	18490781	2008	Pubchem Assay
PRRID_0286	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	CF Patients	Airway epithelial cells and primary PBMCs	LRR	O60602.fasta	O60602	858	Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect.	ELISA	18490781	2008	Pubchem Assay
PRRID_0287	FTT1103 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0287	FTT1103 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0301	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0301	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0302	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0302	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0305	Lipopolysaccharide (LPS) Click for more detail	E. coli 055:B5(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Human prostate epithelial PC3 cells	LRR	O00206.fasta	O00206	839	It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.	ELISA	18649875	2008	Pubchem Assay
PRRID_0305	Lipopolysaccharide (LPS) Click for more detail	E. coli 055:B5(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Human prostate epithelial PC3 cells	LRR	O00206.fasta	O00206	839	It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines.	ELISA	18649875	2008	Pubchem Assay
PRRID_0306	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli 0111:B4 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Galectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.	Galectin-3	Pattern recognition receptor (PRR)	Mice	Bone Marrow Derived Macrophages.	NA	Q9JHE4 .fasta	Q9JHE4	423	Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.	ELISA	18684969	2008	Pubchem Assay
PRRID_0306	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli 0111:B4 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Galectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response.	Galectin-3	Pattern recognition receptor (PRR)	Mice	Bone Marrow Derived Macrophages.	NA	Q9JHE4 .fasta	Q9JHE4	423	Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock.	ELISA	18684969	2008	Pubchem Assay
PRRID_0307	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0307	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0308	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0308	Lipopolysaccharide (LPS) Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0309	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (055:B5) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Epididymis	LRR	NA	NA	NA	Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.	EMSA	18703421	2008	NA
PRRID_0309	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (055:B5) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Epididymis	LRR	NA	NA	NA	Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4.	EMSA	18703421	2008	NA
PRRID_0310	Lipopolysaccharide (LPS) Click for more detail	E. coli(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS stimulation leads to the activation of phospholipase C	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0310	Lipopolysaccharide (LPS) Click for more detail	E. coli(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS stimulation leads to the activation of phospholipase C	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0311	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q15399.fasta	Q15399	786	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0311	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q15399.fasta	Q15399	786	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0312	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	O60603.fasta	O60603	784	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0312	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	O60603.fasta	O60603	784	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0313	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q9Y2C9.fasta	Q9Y2C9	796	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0313	Lipoprotein Click for more detail	Ureaplasma parvum (Bacteria)	NA	NA	Lipoprotein	Natural	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leads to the activation of NF-	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	Q9Y2C9.fasta	Q9Y2C9	796	This induces the inflammatory response.	ELISA	18451040	2008	Pubchem Assay
PRRID_0314	Lipoprotein Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Lipoprotein	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Bone marrow-derived DC	NA	Q9QUN7.fasta	Q9QUN7	784	It has a immunostimulatory role	Cytokines assay	18641340	2008	Pubchem Assay
PRRID_0314	Lipoprotein Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Lipoprotein	Natural	It leads to the activation of NF-Œ∫B and stimulates the production of proinflammatory cytokines such as TNF-alpha and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Bone marrow-derived DC	NA	Q9QUN7.fasta	Q9QUN7	784	It has a immunostimulatory role	Cytokines assay	18641340	2008	Pubchem Assay
PRRID_0316	Lipoteichoic Acid (LTA) Click for more detail	Bacillus subtilis(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cultured human lymphatic endothelium (LEC)	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	18523807	2008	Pubchem Assay
PRRID_0316	Lipoteichoic Acid (LTA) Click for more detail	Bacillus subtilis(Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA-treated LEC increases the expression of E-selectin, ICAM-1, and VCAM-1, moreover it induces the expression of CCL2, CCL5, and CCL20 (Cys-Cys motif chemokines) and of CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8 (Cys-X-Cys motif chemokines).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cultured human lymphatic endothelium (LEC)	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	18523807	2008	Pubchem Assay
PRRID_0318	Lipoteichoic Acid (LTA) Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Upon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-‚ç∫ (TNF-‚ç∫) and nitric oxide (NO).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	RAW 264.7	NA	Q9QUN7.fasta	Q9QUN7	784	LTA contributes to E. faecalis‚Äìinduced inflammatory responses.	ELISA	18634930	2008	Pubchem Assay
PRRID_0318	Lipoteichoic Acid (LTA) Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Upon exposure to E. faecalis LTA, it produces a high level of tumor necrosis factor-‚ç∫ (TNF-‚ç∫) and nitric oxide (NO).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	RAW 264.7	NA	Q9QUN7.fasta	Q9QUN7	784	LTA contributes to E. faecalis‚Äìinduced inflammatory responses.	ELISA	18634930	2008	Pubchem Assay
PRRID_0319	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-Œ± production.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahges	NA	Q9QUN7.fasta	Q9QUN7	784	It resulted in the antibacterial response.	ELISA	18652890	2008	Pubchem Assay
PRRID_0319	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	LTA induces the Stat1 and Stat3 activation via induction of IRF1/2 and interferon-Œ± production.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahges	NA	Q9QUN7.fasta	Q9QUN7	784	It resulted in the antibacterial response.	ELISA	18652890	2008	Pubchem Assay
PRRID_0325	LPS and Œ≤-1,3-glucan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Glycoprotein	Natural	NA	TmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Tenebrio molitor	membrane localised	NA	B1B5K2.fasta	B1B5K2	442	NA	Antibacterial activity assay	18195005	2008	Pubchem Assay
PRRID_0325	LPS and Œ≤-1,3-glucan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Glycoprotein	Natural	NA	TmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Tenebrio molitor	membrane localised	NA	B1B5K2.fasta	B1B5K2	442	NA	Antibacterial activity assay	18195005	2008	Pubchem Assay
PRRID_0326	LPS and Œ≤-1,3-glucan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	NA	Natural	NA	AgGNBPA2	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	NA	NA	NA	NA	NA	Bacterial and Plasmodium infection assays	18237283	2008	NA
PRRID_0326	LPS and Œ≤-1,3-glucan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	NA	Natural	NA	AgGNBPA2	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	NA	NA	NA	NA	NA	Bacterial and Plasmodium infection assays	18237283	2008	NA
PRRID_0327	MG149 Click for more detail	Mycoplasma genitalium (Bacteria)	CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O	NA	Lipoprotein	Natural	On binding to the TLR2, it induces the activation of NF-	Toll-like receptor (TLR1 and Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	NA	NA	NA	It has a immunostimulatory role	ELISA	18474641	2008	NA
PRRID_0327	MG149 Click for more detail	Mycoplasma genitalium (Bacteria)	CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O	NA	Lipoprotein	Natural	On binding to the TLR2, it induces the activation of NF-	Toll-like receptor (TLR1 and Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Kidney cell line, 293T	LRR	NA	NA	NA	It has a immunostimulatory role	ELISA	18474641	2008	NA
PRRID_0331	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It leads to the increased p38 MAPK activity and produce antimicrobial peptide Œ≤-defensin-2 (mBD-2).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Pleural mesothelial cells	NA	Q9QUN7.fasta	Q9QUN7	784	PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.	Antimicrobial assay	18621910	2008	Pubchem Assay
PRRID_0331	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It leads to the increased p38 MAPK activity and produce antimicrobial peptide Œ≤-defensin-2 (mBD-2).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Pleural mesothelial cells	NA	Q9QUN7.fasta	Q9QUN7	784	PGN-activated PMC-derived mBD-2 significantly killed Staphylococcus aureus.	Antimicrobial assay	18621910	2008	Pubchem Assay
PRRID_0332	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN stimulation leads to the activation of phospholipase C	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUN7.fasta	Q9QUN7	784	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0332	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN stimulation leads to the activation of phospholipase C	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages and Dendritic cells	NA	Q9QUN7.fasta	Q9QUN7	784	It has the role in immuno inflammation.	ELISA	18233961	2008	Pubchem Assay
PRRID_0345	SalP Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	human corneal epithelial	NA	O60603.fasta	O60603	784	NA	Western Blot analysis	18191935	2008	Pubchem Assay
PRRID_0345	SalP Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	human corneal epithelial	NA	O60603.fasta	O60603	784	NA	Western Blot analysis	18191935	2008	Pubchem Assay
PRRID_0348	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	BbFREP is able to bind bacteria S. aureus	BbFREP	Multivalent Pattern recognition receptor (PRR)	Amphioxus (Branchiostoma belcheri)	hepatic caecum	fibrinogen-like (FBG) domain	NA	NA	NA	It is responsibe for antibacterial activity of Branchiostoma belcheri recombinant FREP against S. aureus.	ELISA	18533266	2008	NA
PRRID_0348	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	BbFREP is able to bind bacteria S. aureus	BbFREP	Multivalent Pattern recognition receptor (PRR)	Amphioxus (Branchiostoma belcheri)	hepatic caecum	fibrinogen-like (FBG) domain	NA	NA	NA	It is responsibe for antibacterial activity of Branchiostoma belcheri recombinant FREP against S. aureus.	ELISA	18533266	2008	NA
PRRID_0349	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	S. aureus induces IL-8 and TNF-alpha release by CBMC.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cord Blood-Derived Mast Cells (CBMC)	NA	O60603.fasta	O60603	784	S. aureus adheres to, invades, survives in, and stimulates human mast cells with the involvement of CD48 and TLR2.	ELISA	18644875	2008	Pubchem Assay
PRRID_0349	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	S. aureus induces IL-8 and TNF-alpha release by CBMC.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cord Blood-Derived Mast Cells (CBMC)	NA	O60603.fasta	O60603	784	S. aureus adheres to, invades, survives in, and stimulates human mast cells with the involvement of CD48 and TLR2.	ELISA	18644875	2008	Pubchem Assay
PRRID_0351	TUL4 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0351	TUL4 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0352	Type III effector protein Click for more detail	Pseudomonas syringae (Bacteria)	MGCVSSTSRSTGYYSGYESHEEPRAASRPTNSDDRGYETDSEPSSGNLIPNARSVYSESVLWHGTSMQSKIDLRSKGFDAGRKTGGATAGGNANMFMNLSREAQSETRRHHYLSSSQKEAKDFAMFADTSNPTLVRTIGVRNNLSLITDPRTGGTALMTDQSIPRKFVLGSKSSAPGENAKVFRDEMRAAGHNVSTKQAGELLREVQSDSDDDNFPDPDDFIMSRFTG	228	Protein	Natural	NA	RPM1	Pattern recognition receptor (PRR)	Arabidopsis	NA	TIR-NB-LRR	NA	NA	NA	It provides the disease resistance in response to Pto DC3000(avrB).	NA	18424557	2008	NA
PRRID_0352	Type III effector protein Click for more detail	Pseudomonas syringae (Bacteria)	MGCVSSTSRSTGYYSGYESHEEPRAASRPTNSDDRGYETDSEPSSGNLIPNARSVYSESVLWHGTSMQSKIDLRSKGFDAGRKTGGATAGGNANMFMNLSREAQSETRRHHYLSSSQKEAKDFAMFADTSNPTLVRTIGVRNNLSLITDPRTGGTALMTDQSIPRKFVLGSKSSAPGENAKVFRDEMRAAGHNVSTKQAGELLREVQSDSDDDNFPDPDDFIMSRFTG	228	Protein	Natural	NA	RPM1	Pattern recognition receptor (PRR)	Arabidopsis	NA	TIR-NB-LRR	NA	NA	NA	It provides the disease resistance in response to Pto DC3000(avrB).	NA	18424557	2008	NA
PRRID_0353	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0353	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	NA	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0355	Œ≤- 1,3-glucan Click for more detail	Gram negative Bacteria (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	NA	Natural	NA	AgGNBPA1	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	in vitro bacterial binding assay	18237283	2008	NA
PRRID_0355	Œ≤- 1,3-glucan Click for more detail	Gram negative Bacteria (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	NA	Natural	NA	AgGNBPA1	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	in vitro bacterial binding assay	18237283	2008	NA
PRRID_0356	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	AgGNBPA1	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	in vitro bacterial binding assay	18237283	2008	NA
PRRID_0356	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	AgGNBPA1	Gram-negative Bacteria-binding Protein (GNBPs)	Anopheles gambiae	salivary gland and thorax	Œ≤-1,3-glucan binding domain	NA	NA	NA	NA	in vitro bacterial binding assay	18237283	2008	NA
PRRID_0357	Aeromonas hydrophila Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by Aeromonas hydrophila infection.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the bacteria and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0357	Aeromonas hydrophila Click for more detail	A.hydrophilla(Bacteria)	NA	NA	Whole organism	Natural	Toll-like receptor 4 signaling pathway is trigger by Aeromonas hydrophila infection.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Gobiocypris rarus	Gill, Heart, Intestine, Kidney, Liver, Muscle and Spleen tissues	LRR	NA	NA	NA	This is responsible for the recognition of the bacteria and elicit the immune response against it.	NA	19264133	2009	NA
PRRID_0358	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	TmGNBP3	Gram-negative Bacteria-binding Protein (GNBPs)	Tenebrio molitor	membrane localised	NA	NA	NA	NA	NA	Antibacterial activity assay	19712587	2009	NA
PRRID_0358	b-1,3-glucans. Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Glycoprotein	Natural	NA	TmGNBP3	Gram-negative Bacteria-binding Protein (GNBPs)	Tenebrio molitor	membrane localised	NA	NA	NA	NA	NA	Antibacterial activity assay	19712587	2009	NA
PRRID_0362	Chromosomal DNA Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0362	Chromosomal DNA Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0370	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Lipoprotein	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0370	Lipoprotein Click for more detail	S. gordonii (Bacteria)	NA	NA	Lipoprotein	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0371	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Odontoblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0371	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Odontoblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0372	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Dental pulp fibroblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0372	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Dental pulp fibroblasts	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0373	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha, IL-1beta and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Immature dendritic cells	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0373	Lipoteichoic Acid (LTA) Click for more detail	S. aureus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It induces the production of the pro-inflammatory cytokines such as TNF-alpha, IL-1beta and CXCL8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Immature dendritic cells	LRR	O60603.fasta	O60603	784	It has inflammatory/immune response agianst gram-positive bacteria.	ELISA	19250704	2009	Pubchem Assay
PRRID_0374	Lipoteichoic Acid (LTA) Click for more detail	S. gordonii (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0374	Lipoteichoic Acid (LTA) Click for more detail	S. gordonii (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0376	Peptidoglycan (PGN) Click for more detail	S. gordonii (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0376	Peptidoglycan (PGN) Click for more detail	S. gordonii (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Stimulation elicits the production of tumour necrosis factor (TNF) and interleukin (IL)-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay

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