Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0484dsDNA

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vaccinia virus and murine cytomegalovirus (virus)NANANucleic AcidNaturalIt induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1BToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839It is involved in caspase-1-mediated maturation of IL-1βNA206201292010Pubchem Assay
PRRID_0484dsDNA

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vaccinia virus and murine cytomegalovirus (virus)NANANucleic AcidNaturalIt induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1BToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839It is involved in caspase-1-mediated maturation of IL-1βNA206201292010Pubchem Assay
PRRID_0488dsDNA viruses

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HSV, MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0488dsDNA viruses

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HSV, MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0489dsRNA virus

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RSV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0489dsRNA virus

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RSV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0490EBV DNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NR96.fastaQ9NR961032This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0490EBV DNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NR96.fastaQ9NR961032This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0491EBV RNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NYK1.fastaQ9NYK11049This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0491EBV RNA

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Epstein-Barr virus (virus)NANANucleic AcidNaturalViral nucleic acid recognition mediates IFN-α production by pDC.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanPlasmacytoid Dendritic CellsLRRQ9NYK1.fastaQ9NYK11049This results into the inflammatory response.ELISA201781212010Pubchem Assay
PRRID_0496Envelope protein

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RSV (virus)MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV613ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0496Envelope protein

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RSV (virus)MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV613ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0499F protein

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Respiratory syncytial virus (virus) LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC153ProteinNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0499F protein

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Respiratory syncytial virus (virus) LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC153ProteinNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0506FimH

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Escherichia coli strain EC99 (O78) (Bacteria)MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ300ProteinNaturalIt activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNatural Killer cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It aids innate protection against cancer or microbial infections.Chromium (51Cr) release assay for NK cytotoxicity204427102010Pubchem Assay
PRRID_0506FimH

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Escherichia coli strain EC99 (O78) (Bacteria)MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ300ProteinNaturalIt activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicityToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNatural Killer cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It aids innate protection against cancer or microbial infections.Chromium (51Cr) release assay for NK cytotoxicity204427102010Pubchem Assay
PRRID_0508Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0508Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0509Flagellin

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Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalActivates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance.IPAFNOD-like receptor (NLR)HumanNANAQ15399.fastaQ15399786It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0509Flagellin

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Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalActivates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance.IPAFNOD-like receptor (NLR)HumanNANAQ15399.fastaQ15399786It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0511Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It results into the inflammatory responseNA207199932010Pubchem Assay
PRRID_0511Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It results into the inflammatory responseNA207199932010Pubchem Assay
PRRID_0513Flagellin

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Motile Bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalIt itriggers the up-regulation of co-stimulatory signals and Ag-presenting moleculesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocytes, mDCs, Langerhans cells, T cells and NK cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It leads to the induction of DC maturation.NA207131002010Pubchem Assay
PRRID_0513Flagellin

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Motile Bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalIt itriggers the up-regulation of co-stimulatory signals and Ag-presenting moleculesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocytes, mDCs, Langerhans cells, T cells and NK cellsLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It leads to the induction of DC maturation.NA207131002010Pubchem Assay
PRRID_0514Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalinduced the secretion of IL-6 and IL-10Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0514Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalinduced the secretion of IL-6 and IL-10Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0515Flagellin

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Human respiratory syncytial virus (RSV)NANAProteinNaturalActivate NF-κBToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Induce IL-1, IL-6, IL-8, and RANTESNA206720472010Pubchem Assay
PRRID_0515Flagellin

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Human respiratory syncytial virus (RSV)NANAProteinNaturalActivate NF-κBToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Induce IL-1, IL-6, IL-8, and RANTESNA206720472010Pubchem Assay
PRRID_0516Flagellin

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Flagellated bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0516Flagellin

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Flagellated bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0519Flagellin

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Flagellated bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP4Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0519Flagellin

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Flagellated bacteria (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP4Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO60602.fastaO60602858It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0520Flagellin (L94A)

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Pseudomonas aeruginosa (Bacteria)GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP434ProteinNaturalIt elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs).Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)LRRO60602.fastaO60602858It stimulates mucosal surface innate immune response.ELISA201954692010Pubchem Assay
PRRID_0520Flagellin (L94A)

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Pseudomonas aeruginosa (Bacteria)GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP434ProteinNaturalIt elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs).Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHuman corneal epithelial cells (HCECs)LRRO60602.fastaO60602858It stimulates mucosal surface innate immune response.ELISA201954692010Pubchem Assay
PRRID_0524fMLF

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NANANAPeptideSyntheticIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesFormyl peptide receptor 1Pattern recognition receptor (PRR)HumanNeutrophilsNAP21462.fastaP21462350It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0524fMLF

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NANANAPeptideSyntheticIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesFormyl peptide receptor 1Pattern recognition receptor (PRR)HumanNeutrophilsNAP21462.fastaP21462350It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0525FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticFSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signallingToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0525FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticFSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signallingToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0527G-rich oligonucleotides

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Human respiratory syncytial virus (RSV)NANAProteinNaturalSuppress NF-κB activationToll-like receptor 2/4/9 (TLR2/4/9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0527G-rich oligonucleotides

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Human respiratory syncytial virus (RSV)NANAProteinNaturalSuppress NF-κB activationToll-like receptor 2/4/9 (TLR2/4/9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0530Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0530Gardiquimod

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imidazoquinoline (others)CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt activates the NF-Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049It has the role in the inflammation.NA205438572010Pubchem Assay
PRRID_0532gB/gH

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Human cytomegalovirus (virus)NANAGlycoproteinNaturalActivate NF-κBToll-like receptor 2/1 (TLR2/1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAProduce proinflammatory cytokinesNA206720472010NA
PRRID_0532gB/gH

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Human cytomegalovirus (virus)NANAGlycoproteinNaturalActivate NF-κBToll-like receptor 2/1 (TLR2/1)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAProduce proinflammatory cytokinesNA206720472010NA
PRRID_0536Glycoinositol phospholipids

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Trypanosoma (others)C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=ONALipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0536Glycoinositol phospholipids

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Trypanosoma (others)C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=ONALipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0539Glycosylphosphatidyl inositol anchor

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Protozoa (others)NANAPattern-associated molecular patterns (PAMPs)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0539Glycosylphosphatidyl inositol anchor

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Protozoa (others)NANAPattern-associated molecular patterns (PAMPs)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0541Glycosylphosphophatidyl inositol mucin

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Trypanosoma (others)NANAGlycoproteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0541Glycosylphosphophatidyl inositol mucin

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Trypanosoma (others)NANAGlycoproteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0542gp350/gp220

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Epstein-Barr virus (virus)MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV907GlycoproteinNaturalActivate NF-κBToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Induce MCP-1 productionNA206720472010Pubchem Assay
PRRID_0542gp350/gp220

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Epstein-Barr virus (virus)MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV907GlycoproteinNaturalActivate NF-κBToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Induce MCP-1 productionNA206720472010Pubchem Assay
PRRID_0543GPI anchor

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalGPIs binds to the TLR2 and activaes the downstream processesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanmacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Recognition and phagocytosisNA207292072010Pubchem Assay
PRRID_0543GPI anchor

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T. gondii (others)NANAPattern-associated molecular patterns (PAMPs)NaturalGPIs binds to the TLR2 and activaes the downstream processesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanmacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Recognition and phagocytosisNA207292072010Pubchem Assay
PRRID_0544HA

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Measles virus (virus)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAProteinNaturalActivate NF-κBToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12NA206720472010Pubchem Assay
PRRID_0544HA

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Measles virus (virus)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONAProteinNaturalActivate NF-κBToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12NA206720472010Pubchem Assay
PRRID_0548Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17AToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPBMCsLRRO00206.fastaO00206839The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0548Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17AToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPBMCsLRRO00206.fastaO00206839The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0549Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17ADectin-1C type Lectin (CTL/CLR)HumanPBMCsNAQ9BXN2.fastaQ9BXN2247The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0549Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17ADectin-1C type Lectin (CTL/CLR)HumanPBMCsNAQ9BXN2.fastaQ9BXN2247The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0552Hemagglutinin

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Measles virus (virus)MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR617GlycoproteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0552Hemagglutinin

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Measles virus (virus)MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR617GlycoproteinNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0556Hemozoin

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Plasmodium (others)CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]NANANaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0556Hemozoin

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Plasmodium (others)CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]NANANaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫NA206201292010Pubchem Assay
PRRID_0564HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalinduced cellular activation and NF-κB-dependent transcriptionToll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainNANANAIt generate the inflammatory response similar to intiated by LPSNA206899292010NA
PRRID_0564HMGB1

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Host (Endogenous) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalinduced cellular activation and NF-κB-dependent transcriptionToll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293Leucine-rich Repeat (LRR) DomainNANANAIt generate the inflammatory response similar to intiated by LPSNA206899292010NA
PRRID_0565HpaA

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H. pylori (Bacteria)NANALipoproteinNaturalIt activates the TLR2, which leads to the secretion of IL-12 and IFN-Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNatural Killer cellsLRRO60603.fastaO60603784It has a immunostimulatory roleELISA201301072010Pubchem Assay
PRRID_0565HpaA

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H. pylori (Bacteria)NANALipoproteinNaturalIt activates the TLR2, which leads to the secretion of IL-12 and IFN-Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNatural Killer cellsLRRO60603.fastaO60603784It has a immunostimulatory roleELISA201301072010Pubchem Assay
PRRID_0566HRG-IgG complex

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Human (others)NANAGlycoproteinNaturalHistidine-rich glycoprotein recruits IgG to facilitate necrotic cell clearance via FcFcFc receptorHumanPhagocytesNAP12314.fastaP12314374It facilitates the proinflammatory innate immune response promote the clearance of necrotic cells.Phagocytosis assay200716622010Pubchem Assay
PRRID_0566HRG-IgG complex

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Human (others)NANAGlycoproteinNaturalHistidine-rich glycoprotein recruits IgG to facilitate necrotic cell clearance via FcFcFc receptorHumanPhagocytesNAP12314.fastaP12314374It facilitates the proinflammatory innate immune response promote the clearance of necrotic cells.Phagocytosis assay200716622010Pubchem Assay
PRRID_0578imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0578imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0579imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0579imiquimod (R-837) and resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0600Lactoferrin

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Human (others)MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK711GlycoproteinNaturalIt activates the NF-Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman monocytic leukemia cell line, THP-1LRRO00206.fastaO00206839It has a immunostimulatory roleEMSA203459052010Pubchem Assay
PRRID_0600Lactoferrin

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Human (others)MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK711GlycoproteinNaturalIt activates the NF-Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman monocytic leukemia cell line, THP-1LRRO00206.fastaO00206839It has a immunostimulatory roleEMSA203459052010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0606lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0606lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay
PRRID_0629Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduced the secretion of IL-6 and IL-9Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanperipheral mononuclear cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207031562010Pubchem Assay