Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0484 | dsDNA Click for more detail | vaccinia virus and murine cytomegalovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1B | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | It is involved in caspase-1-mediated maturation of IL-1β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0484 | dsDNA Click for more detail | vaccinia virus and murine cytomegalovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1B | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | It is involved in caspase-1-mediated maturation of IL-1β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0488 | dsDNA viruses Click for more detail | HSV, MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0488 | dsDNA viruses Click for more detail | HSV, MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0489 | dsRNA virus Click for more detail | RSV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0489 | dsRNA virus Click for more detail | RSV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0490 | EBV DNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0490 | EBV DNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0491 | EBV RNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0491 | EBV RNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0496 | Envelope protein Click for more detail | RSV (virus) | MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV | 613 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0496 | Envelope protein Click for more detail | RSV (virus) | MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV | 613 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0499 | F protein Click for more detail | Respiratory syncytial virus (virus) | LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC | 153 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0499 | F protein Click for more detail | Respiratory syncytial virus (virus) | LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC | 153 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0506 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0506 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0508 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0508 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0509 | Flagellin Click for more detail | Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | IPAF | NOD-like receptor (NLR) | Human | NA | NA | Q15399.fasta | Q15399 | 786 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0509 | Flagellin Click for more detail | Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | IPAF | NOD-like receptor (NLR) | Human | NA | NA | Q15399.fasta | Q15399 | 786 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0511 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It results into the inflammatory response | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0511 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It results into the inflammatory response | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0513 | Flagellin Click for more detail | Motile Bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes, mDCs, Langerhans cells, T cells and NK cells | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the induction of DC maturation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0513 | Flagellin Click for more detail | Motile Bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes, mDCs, Langerhans cells, T cells and NK cells | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the induction of DC maturation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0514 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced the secretion of IL-6 and IL-10 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0514 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced the secretion of IL-6 and IL-10 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0515 | Flagellin Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Induce IL-1, IL-6, IL-8, and RANTES | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0515 | Flagellin Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Induce IL-1, IL-6, IL-8, and RANTES | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0516 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0516 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0519 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP4 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0519 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP4 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0520 | Flagellin (L94A) Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | It elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs). | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | LRR | O60602.fasta | O60602 | 858 | It stimulates mucosal surface innate immune response. | ELISA | 20195469 | 2010 | Pubchem Assay |
| PRRID_0520 | Flagellin (L94A) Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | It elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs). | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | LRR | O60602.fasta | O60602 | 858 | It stimulates mucosal surface innate immune response. | ELISA | 20195469 | 2010 | Pubchem Assay |
| PRRID_0524 | fMLF Click for more detail | NA | NA | NA | Peptide | Synthetic | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Formyl peptide receptor 1 | Pattern recognition receptor (PRR) | Human | Neutrophils | NA | P21462.fasta | P21462 | 350 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0524 | fMLF Click for more detail | NA | NA | NA | Peptide | Synthetic | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Formyl peptide receptor 1 | Pattern recognition receptor (PRR) | Human | Neutrophils | NA | P21462.fasta | P21462 | 350 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0525 | FSL-1 Click for more detail | Mycoplasma (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | FSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signalling | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0525 | FSL-1 Click for more detail | Mycoplasma (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | FSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signalling | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0527 | G-rich oligonucleotides Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Suppress NF-κB activation | Toll-like receptor 2/4/9 (TLR2/4/9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0527 | G-rich oligonucleotides Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Suppress NF-κB activation | Toll-like receptor 2/4/9 (TLR2/4/9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0530 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0530 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0532 | gB/gH Click for more detail | Human cytomegalovirus (virus) | NA | NA | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Produce proinflammatory cytokines | NA | 20672047 | 2010 | NA |
| PRRID_0532 | gB/gH Click for more detail | Human cytomegalovirus (virus) | NA | NA | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Produce proinflammatory cytokines | NA | 20672047 | 2010 | NA |
| PRRID_0536 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0536 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0539 | Glycosylphosphatidyl inositol anchor Click for more detail | Protozoa (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0539 | Glycosylphosphatidyl inositol anchor Click for more detail | Protozoa (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0541 | Glycosylphosphophatidyl inositol mucin Click for more detail | Trypanosoma (others) | NA | NA | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0541 | Glycosylphosphophatidyl inositol mucin Click for more detail | Trypanosoma (others) | NA | NA | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0542 | gp350/gp220 Click for more detail | Epstein-Barr virus (virus) | MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV | 907 | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce MCP-1 production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0542 | gp350/gp220 Click for more detail | Epstein-Barr virus (virus) | MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV | 907 | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce MCP-1 production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0543 | GPI anchor Click for more detail | T. gondii (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GPIs binds to the TLR2 and activaes the downstream processes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Recognition and phagocytosis | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0543 | GPI anchor Click for more detail | T. gondii (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GPIs binds to the TLR2 and activaes the downstream processes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Recognition and phagocytosis | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0544 | HA Click for more detail | Measles virus (virus) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12 | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0544 | HA Click for more detail | Measles virus (virus) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12 | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0548 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | PBMCs | LRR | O00206.fasta | O00206 | 839 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0548 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | PBMCs | LRR | O00206.fasta | O00206 | 839 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0549 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Dectin-1 | C type Lectin (CTL/CLR) | Human | PBMCs | NA | Q9BXN2.fasta | Q9BXN2 | 247 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0549 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Dectin-1 | C type Lectin (CTL/CLR) | Human | PBMCs | NA | Q9BXN2.fasta | Q9BXN2 | 247 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0552 | Hemagglutinin Click for more detail | Measles virus (virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0552 | Hemagglutinin Click for more detail | Measles virus (virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0556 | Hemozoin Click for more detail | Plasmodium (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | NA | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0556 | Hemozoin Click for more detail | Plasmodium (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | NA | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0564 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | induced cellular activation and NF-κB-dependent transcription | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It generate the inflammatory response similar to intiated by LPS | NA | 20689929 | 2010 | NA |
| PRRID_0564 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | induced cellular activation and NF-κB-dependent transcription | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It generate the inflammatory response similar to intiated by LPS | NA | 20689929 | 2010 | NA |
| PRRID_0565 | HpaA Click for more detail | H. pylori (Bacteria) | NA | NA | Lipoprotein | Natural | It activates the TLR2, which leads to the secretion of IL-12 and IFN- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Natural Killer cells | LRR | O60603.fasta | O60603 | 784 | It has a immunostimulatory role | ELISA | 20130107 | 2010 | Pubchem Assay |
| PRRID_0565 | HpaA Click for more detail | H. pylori (Bacteria) | NA | NA | Lipoprotein | Natural | It activates the TLR2, which leads to the secretion of IL-12 and IFN- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Natural Killer cells | LRR | O60603.fasta | O60603 | 784 | It has a immunostimulatory role | ELISA | 20130107 | 2010 | Pubchem Assay |
| PRRID_0566 | HRG-IgG complex Click for more detail | Human (others) | NA | NA | Glycoprotein | Natural | Histidine-rich glycoprotein recruits IgG to facilitate necrotic cell clearance via Fc | Fc | Fc receptor | Human | Phagocytes | NA | P12314.fasta | P12314 | 374 | It facilitates the proinflammatory innate immune response promote the clearance of necrotic cells. | Phagocytosis assay | 20071662 | 2010 | Pubchem Assay |
| PRRID_0566 | HRG-IgG complex Click for more detail | Human (others) | NA | NA | Glycoprotein | Natural | Histidine-rich glycoprotein recruits IgG to facilitate necrotic cell clearance via Fc | Fc | Fc receptor | Human | Phagocytes | NA | P12314.fasta | P12314 | 374 | It facilitates the proinflammatory innate immune response promote the clearance of necrotic cells. | Phagocytosis assay | 20071662 | 2010 | Pubchem Assay |
| PRRID_0578 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0578 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0579 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0579 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0600 | Lactoferrin Click for more detail | Human (others) | MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK | 711 | Glycoprotein | Natural | It activates the NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human monocytic leukemia cell line, THP-1 | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | EMSA | 20345905 | 2010 | Pubchem Assay |
| PRRID_0600 | Lactoferrin Click for more detail | Human (others) | MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK | 711 | Glycoprotein | Natural | It activates the NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human monocytic leukemia cell line, THP-1 | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | EMSA | 20345905 | 2010 | Pubchem Assay |
| PRRID_0604 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0604 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0605 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0605 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0606 | lipo-arabinomannan Click for more detail | M. tuberculosis (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Binding of ligand leads to the inhibition of phagolysosome maturation | Mannose receptor | Mannose receptor (MR) | Human | NA | NA | P22897.fasta | P22897 | 1456 | It ensure its survival of M. toberculosis in the host | NA | 20488784 | 2010 | Pubchem Assay |
| PRRID_0606 | lipo-arabinomannan Click for more detail | M. tuberculosis (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Binding of ligand leads to the inhibition of phagolysosome maturation | Mannose receptor | Mannose receptor (MR) | Human | NA | NA | P22897.fasta | P22897 | 1456 | It ensure its survival of M. toberculosis in the host | NA | 20488784 | 2010 | Pubchem Assay |
| PRRID_0607 | lipomannas Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0607 | lipomannas Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |