Please click on the ID to see detailed information about each entry.
| ID | Name | Sequence | Assay | Nature of peptide or cargo | Tissue permeability (value with units) | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1380 | HSV-1 gD 1-29 (group1) | SKYALVDASLKMSDP NRFRGKDLPVLDQL | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1381 | HSV-1 gD 22-52 (group-1) | DLPVLQLTHPPGVRRV YHIQAGLPDPFQPPS | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1382 | HSV-1 gD 49-82 (group-2) | QPPSLPITVYAVLERA CRSVLLNAPSEAPQIVR | FACS | Intranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva. | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1383 | HSV-1 gD 77-104 (group-1) | APQIVRGASEDVRK QPYNLTIAWFRMGG | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1384 | HSV-1 gD 96-123 (group 3) | TIAWFRMGGNCAIP ITVMEYTECSYNKS | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1385 | HSV-1 gD 121-152 (group-1) | NKSLGACPIRTQPRW NYYDSFSAVSEDNLGF | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1386 | HSV-1 gD 146-179 (group-2) | EDNLGFLMHSPSFETSGT YLRLVKINDWTEITQF | FACS | Intranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva. | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1387 | HSV-1 gD 176-206 (group-3) | ITQFILEHRAKGSCKY ALPLRIPPSACLSPQ | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1388 | HSV-1 gD 200-234 (group-2) | SACLSPQAYQQGVTV DSIGMLPRFIPENQR TVAVY | FACS | Intranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva. | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1389 | HSV-1 gD 228-257(group-3) | QRTVAVYSLKIAGWH GPKAPYTSTLLPPEL | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1390 | HSV-1 gD 332-358 (group-3) | ICGIVYWMRRHTQKA PKRIRLPHIRED | FACS | Intranasal aministration of HSV-gD peptides plus CpG can induce local ocular mucosal and systemic T-cell responses | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1391 | HSV-1 gD 287-317 (group-2) | APQIPPNWHIPSIQDA ATPYHPPATPNNMGL | FACS | Intranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva. | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels | Nasal cavity of New Zealand White rabbits | 20089796 |
| 1392 | Retro-inverso HA 91-108 | lsaydpvdypysnsfakc | ELISA | Antigenic properties with increased resistance to proteolytic activity and consequently longer persistence in vivo | Retro-inverso peptide induced high levels of serum IgG and lung IgA antibodies | Nasal cavity of mouse | 12220890 |
| 1393 | Capsaicin | T | Immunocytochemistry, electron microscopy | Repeated capsaicin applications are assumed to cause desensitization of the nasal mucosa and a decreased secretory response | The number of goblet cells was increased in the nasal region. CGRP-Iike activity was decreased in biopsies taken from the test sides of the paranasal sinuses when compared to control. | Nasal mucosa of New Zealand White rabbits | 8737771 |
| 1394 | Bradykinin | RPPGFSPFR | Evan's blue dye | Small endogenous peptide mediators formed de novo at sites of tissue damage where it has important actions that contribute to the acute inflammatory response. | Instillation of bradykinin increased extravasation of Evans blue dye to 93.5±7.5 ng/ml from baseline 8.54±0.93 ng/ml | Nasal mucosa of guinea pigs | 8719791 |
| 1395 | Kallidin | KRPPGFSPFR | Pain response evaluated by a visual analogue scale | Produces a mildly painful response when topically applied in nasal mucosa | The maximal painful response was attained 1-2 min after drug administration and faded after 5 min | Nostrils of human subjects | 8443036 |
| 1396 | Capsaicin | T | Pain response evaluated by a visual analogue scale | Nociceptive responses to various noxious stimuli are inhibited or abolished in capsaicin-treated animals. This effect is presumed to arise from the toxic action of capsaicin and the consequent neurodegeneration of C-fibre nociceptors. | Capsaicin (50 nmol, 50 µl) produced a remarkable pain response (considered as 100 in the VAS), sneezing and secretion of copious flow of nasal fluid. Capsaicin applications were performed every day for 5-7 days until the painful response reported by each subject was reduced by about 80% | Nostrils of human subjects | 8443036 |
| 1397 | Botulinum toxin type A | Botulinum neurotoxin A light chain (PFVNKQF NYKDPVNGVDIAYIKIPN AGQMQPVKAFKIHNKI WVIPERDTFTNPEEGD LNPPPEAKQVPVSYY DSTYLSTDNEKDNYLK GVTKLFERIYSTDLGR MLLTSIVRGIPFWGG STIDTELKVIDTNCIN VIQPDGSYRSEE LNLVIIGPSADIIQFE CKSFGHEVLNLTRNGY GSTQYIRFSPDFT FGFEESLEVDTNPLL | Weights of the nasal secretion were collected and compared. | Potent inhibitor of cholinergic motor nerves. | Topically applied botulinum toxin reduced neurally evoked rhinorrhea by an average of 41%. | Nasal cavity of male mongrel dogs | 7700663 |
| 1398 | Capsaicin | T | Immunocytochemistry | Affects not only sensory nerves but impacts on THI sympathetic nerves in the nasal mucosa | In the nasal mucosa of toluene diisocyanate sensitized guinea pigs, substance P (SP)- and tyrosine hydroxylase (TH)-like immunoreactive (SPI and THI) fibers seemed to decrease after capsaicin application | Nasal mucosa of guinea pigs | 7680838 |
| 1399 | Capsaicin | T | Visual analogue scale method was used to measure burning and painful sensation on application of capsaicin. | Capsaicin, the pungent ingredient of red peppers, when applied into the nasal mucosa induces violent sneezing, vasodilation and increases vascular permeability. | The application of capsaicin into the human nasal mucosa was immediately followed by a painful sensation that was described by all the subjects as burning. A variable number of sneezes (from I up to 8) also occurred. | Human nasal mucosa | 3370386 |
| 1400 | Capsaicin | T | The amount of nasal mucosa secreted in response to capsaicin was weighed. | Capsaicin activates sensory nerve endings in the nose and the paranasal sinuses, thereby stimulating protective reflexes involved in sneezing and in increased vasopermeability and stimulate mucociliary activity | Capsaicin stimulated the secretion of nasal fluid in a dose-dependent manner when administered as a single dose. | Nasal mucosa of rats | 2480171 |
| 1401 | Bombesin | Pyr-QRLGNQWAVGHLM | Anterior rhinomanimetry, Nasal provocation, Lowrys method | It may act as secretagogue in human nasal mucosa in vivo | Bombesin stimulates nasal secretion from submucosal glands and possibly epithelial cell without affecting vascular permeability. Total protein secretion was increased after 100 nmol (P=0.041) and 1000 nmol (P=0.009) of bombesin compared with baseline, significant lysozyme (24±3 µg/ml, P<0.05) secretion occurred after 1000 nmol. | Nasal mucosa of humans | 1733281 |