PRIMARY INFORMATION |
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ID | 1400 |
PMID | 2480171 |
Year | 1989 |
Sequence | T |
Name | Capsaicin |
Length | 1 |
N-Terminal Modification | Free |
C-Terminal Modification | 7-methyl octa-5-ene |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | OH on benzene ring of tyrosine |
Origin of Peptide | Component of chili peppers |
Nature of Peptide/Cargo | Capsaicin activates sensory nerve endings in the nose and the paranasal sinuses, thereby stimulating protective reflexes involved in sneezing and in increased vasopermeability and stimulate mucociliary activity |
Mechanism | Not mentioned |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | The amount of nasal mucosa secreted in response to capsaicin was weighed. |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | 1630nmol |
Incubation time | 6 days |
Tissue permeability (value with units) | Capsaicin stimulated the secretion of nasal fluid in a dose-dependent manner when administered as a single dose. |
Tissue Sample | Nasal mucosa of rats |
Ex vivo/In vivo/In vitro | in vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |