Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1388

PRIMARY INFORMATION
ID1388
PMID20089796
Year2010
SequenceSACLSPQAYQQGVTV
DSIGMLPRFIPENQR
TVAVY
NameHSV-1 gD 200-234 (group-2)
Length35
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideT-cell epitope peptide identified from HSV1-gD
Nature of Peptide/CargoIntranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFACS
EnhancerCpG adjuvant
Properties of enhancerNot mentioned
Concentration50 µl per nasal cavity
Incubation timeImmunized on 0,14 and 21 days. Euthanized after 10 days.
Tissue permeability (value with units)Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels
Tissue SampleNasal cavity of New Zealand White rabbits
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N1[C@H]([C@H](O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)NCC(=O)N[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N4[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O)Cc5ccc(cc5)O)C(C)C)C)C(C)C)[C@H](O)
C)CCCNC(=N)N)CCC(=O)N)CC(=O)N)CCC(=O)O)CCC4)[C@H](CCC[C@H]2C)C)Cc2ccccc2)CCCNC(=N)
N)CCC3)CC(C)C)CCSC)[C@H](CC)C)CO)CC(=O)O)C(C)C)[C@H](O)C)CCC(=O)N)
CCC(=O)N)Cc2ccc(cc2)O)C)CCC(=O)N)CCC1)CO)CC(C)C)CS)C)CO