PRIMARY INFORMATION |
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ID | 1401 |
PMID | 1733281 |
Year | 1992 |
Sequence | Pyr-QRLGNQWAVGHLM |
Name | Bombesin |
Length | 14 |
N-Terminal Modification | Free |
C-Terminal Modification | Amidation |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | Pyroglutamic acid |
Origin of Peptide | Originally isolated from the skin of the European fire-bellied toad (Bombina bombina) |
Nature of Peptide/Cargo | It may act as secretagogue in human nasal mucosa in vivo |
Mechanism | Not mentioned |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Anterior rhinomanimetry, Nasal provocation, Lowrys method |
Enhancer | None |
Properties of enhancer | Not applicable |
Concentration | 1nmol-1000nmol (1mM diluted with saline) |
Incubation time | 10 minutes |
Tissue permeability (value with units) | Bombesin stimulates nasal secretion from submucosal glands and possibly epithelial cell without affecting vascular permeability. Total protein secretion was increased after 100 nmol (P=0.041) and 1000 nmol (P=0.009) of bombesin compared with baseline, significant lysozyme (24±3 µg/ml, P<0.05) secretion occurred after 1000 nmol. |
Tissue Sample | Nasal mucosa of humans |
Ex vivo/In vivo/In vitro | in vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |