| PRIMARY INFORMATION |
|---|
| ID | 1401 |
| PMID | 1733281 |
| Year | 1992 |
| Sequence | Pyr-QRLGNQWAVGHLM |
| Name | Bombesin |
| Length | 14 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | Pyroglutamic acid |
| Origin of Peptide | Originally isolated from the skin of the European fire-bellied toad (Bombina bombina) |
| Nature of Peptide/Cargo | It may act as secretagogue in human nasal mucosa in vivo |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Anterior rhinomanimetry, Nasal provocation, Lowrys method |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 1nmol-1000nmol (1mM diluted with saline) |
| Incubation time | 10 minutes |
| Tissue permeability (value with units) | Bombesin stimulates nasal secretion from submucosal glands and possibly epithelial cell without affecting vascular permeability. Total protein secretion was increased after 100 nmol (P=0.041) and 1000 nmol (P=0.009) of bombesin compared with baseline, significant lysozyme (24±3 µg/ml, P<0.05) secretion occurred after 1000 nmol. |
| Tissue Sample | Nasal mucosa of humans |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
