| PRIMARY INFORMATION |
|---|
| ID | 1396 |
| PMID | 8443036 |
| Year | 1993 |
| Sequence | T |
| Name | Capsaicin |
| Length | 1 |
| N-Terminal Modification | Free |
| C-Terminal Modification | 7-methyl octa-5-ene |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | OH on benzene ring of tyrosine |
| Origin of Peptide | Component of chili peppers |
| Nature of Peptide/Cargo | Nociceptive responses to various noxious stimuli are inhibited or abolished in capsaicin-treated animals. This effect is presumed to arise from the toxic action of capsaicin and the consequent neurodegeneration of C-fibre nociceptors. |
| Mechanism | Neurodegeneration of C-fibre nociceptors |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Pain response evaluated by a visual analogue scale |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 50 µl containing 50 nmol of capsaicin |
| Incubation time | 5-7 consecutive days |
| Tissue permeability (value with units) | Capsaicin (50 nmol, 50 µl) produced a remarkable pain response (considered as 100 in the VAS), sneezing and secretion of copious flow of nasal fluid. Capsaicin applications were performed every day for 5-7 days until the painful response reported by each subject was reduced by about 80% |
| Tissue Sample | Nostrils of human subjects |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
