| ID | 1382 | |
| PMID | 20089796 | |
| Year | 2010 | |
| Sequence | QPPSLPITVYAVLERA CRSVLLNAPSEAPQIVR | |
| Name | HSV-1 gD 49-82 (group-2) | |
| Length | 34 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | T-cell epitope peptide identified from HSV1-gD | |
| Nature of Peptide/Cargo | Intranasal immunizations with group 2 peptides induced strong CD4+ T cell proliferation in the conjunctiva. | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | FACS | |
| Enhancer | CpG adjuvant | |
| Properties of enhancer | Not mentioned | |
| Concentration | 50 µl per nasal cavity | |
| Incubation time | Immunized on 0,14 and 21 days. Euthanized after 10 days.21 days | |
| Tissue permeability (value with units) | Detectable HSV-1-specific CD4+ T cell responses were induced at the local (conjunctiva) and systemic (spleen) levels. | |
| Tissue Sample | Nasal cavity of New Zealand White rabbits | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
| |
| SMILES | N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C (=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H] (C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O) N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N [C@H](C(=O)N[C@H](C=O)C)CC(=O)N)CC(C)C)CC(C)C) C(C)C)CO)CCCNC(=N)N)CS)C)CCCNC(=N)N) CCC(=O)O)CC(C)C)C(C)C)C)Cc1ccc(cc1)O)C (C)C)[C@H](O)C)[C@H](CC)C)CCC)CC(C) C)CO)CCC)CCC)CCC(=O)N | |