| PRIMARY INFORMATION |
|---|
| ID | 1399 |
| PMID | 3370386 |
| Year | 1988 |
| Sequence | T |
| Name | Capsaicin |
| Length | 1 |
| N-Terminal Modification | Free |
| C-Terminal Modification | 7-methyl octa-5-ene |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | OH on benzene ring of tyrosine |
| Origin of Peptide | Component of chili peppers |
| Nature of Peptide/Cargo | Capsaicin, the pungent ingredient of red peppers, when applied into the nasal mucosa induces violent sneezing, vasodilation and increases vascular permeability. |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Visual analogue scale method was used to measure burning and painful sensation on application of capsaicin. |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 75 µg |
| Incubation time | 10 minutes |
| Tissue permeability (value with units) | The application of capsaicin into the human nasal mucosa was immediately followed by a painful sensation that was described by all the subjects as burning. A variable number of sneezes (from I up to 8) also occurred. |
| Tissue Sample | Human nasal mucosa |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
