Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1536	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1536	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1537	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1537	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q9HC29.fasta	Q9HC29	1040	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1538	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1538	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium	Intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24829146	2014	Pubchem_assay
PRRID_1539	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1539	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1540	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1541	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	cell surface	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24825342	2014	Pubchem_assay
PRRID_1541	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	cell surface	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24825342	2014	Pubchem_assay
PRRID_1542	Peptidoglycan (PGN) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	Histological analyses, Real-time PCR analysis, Western blotting	24815695	2014	Pubchem_assay
PRRID_1542	Peptidoglycan (PGN) Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	Histological analyses, Real-time PCR analysis, Western blotting	24815695	2014	Pubchem_assay
PRRID_1543	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1543	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1544	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1544	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1545	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1545	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1546	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1546	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q9DD78.fasta	Q9DD78	793	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1547	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	peripheral blood mononuclear cells such as macrophages, granulocytes, dendritic cells, and along the intestinal epithelial cells	intracellular receptors	Q9HC29.fasta	Q9HC29	1040	recognizes fragments of the bacterial cell wall.	Luciferase assay	24790089	2014	Pubchem_assay
PRRID_1547	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	peripheral blood mononuclear cells such as macrophages, granulocytes, dendritic cells, and along the intestinal epithelial cells	intracellular receptors	Q9HC29.fasta	Q9HC29	1040	recognizes fragments of the bacterial cell wall.	Luciferase assay	24790089	2014	Pubchem_assay
PRRID_1548	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1548	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Mice	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1549	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	Mice	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1549	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	Mice	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1550	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Human	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1550	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Nod-like receptor 1 (NLR1)	NOD-like receptor (NLR)	Human	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1551	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	Human	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1551	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	Human	lymphocytes, macrophages, dendritic cells	intracellular receptors	NA	NA	NA	triggering of these receptors induces activation of the NF-Œ∫B pathway and consequently, an immune response	NA	24779390	2014	NA
PRRID_1552	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771328	2014	NA
PRRID_1552	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771328	2014	NA
PRRID_1553	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771328	2014	NA
PRRID_1553	Peptidoglycan (PGN) Click for more detail	Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN is known to be a potent activator of NF-Œ∫B and TNF-Œ± through TLR2	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24771328	2014	NA
PRRID_1554	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1554	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1555	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	MjFREP2	FREP	NA	NA	NA	NA	NA	NA	NA	NA	24830772	2014	NA
PRRID_1555	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	MjFREP2	FREP	NA	NA	NA	NA	NA	NA	NA	NA	24830772	2014	NA
PRRID_1556	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1556	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1557	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1557	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1558	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1558	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1559	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1559	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1560	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	European and African Children	most adult tissues	signals via a caspase- activated recruitment domain (CARD)	Q9Y239.fasta	Q9Y239	953	induce autophagy and inflammatory responses in host cells.	ELISA	24746552	2014	Pubchem_assay
PRRID_1560	Peptidoglycan (PGN) Click for more detail	Gram negative Bacteria (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	European and African Children	most adult tissues	signals via a caspase- activated recruitment domain (CARD)	Q9Y239.fasta	Q9Y239	953	induce autophagy and inflammatory responses in host cells.	ELISA	24746552	2014	Pubchem_assay
PRRID_1564	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	NA	NA	NA	NA	NA	NA	NA	NA	23796791	2014	NA
PRRID_1564	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	PGN-binding proteins (PGRPs)	Peptidoglycan Recognition Receptor (PGRPs)	NA	NA	NA	NA	NA	NA	NA	NA	23796791	2014	NA
PRRID_1780	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	CfLRRop-3	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26826425	2016	NA
PRRID_1780	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	CfLRRop-3	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26826425	2016	NA
PRRID_1784	Peptidoglycan (PGN) Click for more detail	Gram-negative bacteria Escherichia coli, Vibrio anguillarum	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection and immunostimulant	CgPGRPS2	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1784	Peptidoglycan (PGN) Click for more detail	Gram-negative bacteria Escherichia coli, Vibrio anguillarum	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection and immunostimulant	CgPGRPS2	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1787	Peptidoglycan (PGN) Click for more detail	Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection and immunostimulant	CgPGRPS2	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1787	Peptidoglycan (PGN) Click for more detail	Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection and immunostimulant	CgPGRPS2	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1790	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	MnCTLDcp2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1790	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	MnCTLDcp2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1839	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection	CgPGRPS4	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1839	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Bacterial infection	CgPGRPS4	Peptidoglycan Recognition Receptor (PGRPs)	Crassostrea gigas	Cytoplasm	one typical PGRP/amidase domain	NA	NA	NA	Activate NF-kB	PAMPs binding assay	28042081	2016	NA
PRRID_1840	Peptidoglycan (PGN) Click for more detail	Gram negative bacteria, Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	DjCTL	C type Lectin (CTL/CLR)	Dugesia japonica	Pharyngeal and epidermis	Doamin of CLECT	A0A1L2DBR5.fasta	A0A1L2DBR5	107	foreign invaders and phagocytize or encapsulate the aggregates of killed bacteria which have been digested in intestinal cavity.	Microbial binding assay	27565408	2016	Pubchem_assay
PRRID_1840	Peptidoglycan (PGN) Click for more detail	Gram negative bacteria, Gram-positive bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	DjCTL	C type Lectin (CTL/CLR)	Dugesia japonica	Pharyngeal and epidermis	Doamin of CLECT	A0A1L2DBR5.fasta	A0A1L2DBR5	107	foreign invaders and phagocytize or encapsulate the aggregates of killed bacteria which have been digested in intestinal cavity.	Microbial binding assay	27565408	2016	Pubchem_assay
PRRID_1841	Peptidoglycan (PGN) Click for more detail	A.hydrophilla(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Cause bacterial infection, immunostimulant	PcFBN1	FREP	Procambarus clarkii	hepatopancreas and hemocyte	FBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.	NA	NA	NA	trigger complement system via the lectin-dependent pathway.	Ligand binding assay	27417229	2016	NA
PRRID_1841	Peptidoglycan (PGN) Click for more detail	A.hydrophilla(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Cause bacterial infection, immunostimulant	PcFBN1	FREP	Procambarus clarkii	hepatopancreas and hemocyte	FBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.	NA	NA	NA	trigger complement system via the lectin-dependent pathway.	Ligand binding assay	27417229	2016	NA
PRRID_1842	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Hexokinase	Pattern recognition receptor (PRR)	Human	Macrophages, Dendritic cells	NA	P52789.fasta	P52789	917	Metabolic enzyme, Trigger NLRP3 Inflammasome Activation and IL-1b Production	Proximity Ligation assay	27374331	2016	Pubchem_assay
PRRID_1842	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Hexokinase	Pattern recognition receptor (PRR)	Human	Macrophages, Dendritic cells	NA	P52789.fasta	P52789	917	Metabolic enzyme, Trigger NLRP3 Inflammasome Activation and IL-1b Production	Proximity Ligation assay	27374331	2016	Pubchem_assay
PRRID_1843	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	CgSiglec-1	Pattern recognition receptor (PRR)	Crassostrea gigas	NA	CRD or C1q domain	NA	NA	NA	act as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.	NA	27032602	2016	NA
PRRID_1843	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	CgSiglec-1	Pattern recognition receptor (PRR)	Crassostrea gigas	NA	CRD or C1q domain	NA	NA	NA	act as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.	NA	27032602	2016	NA
PRRID_1844	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It enhances microbe agglutination and haemocytes encapsulation.	Galectin	Pattern recognition receptor (PRR)	Eriocheir sinensis	Hepatopancreas	CRD	NA	NA	NA	It provies immune defense against invading microbes.	ELISA	27095174	2016	NA
PRRID_1844	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It enhances microbe agglutination and haemocytes encapsulation.	Galectin	Pattern recognition receptor (PRR)	Eriocheir sinensis	Hepatopancreas	CRD	NA	NA	NA	It provies immune defense against invading microbes.	ELISA	27095174	2016	NA
PRRID_1937	b-1,3-glucan and lipopolysaccharide Click for more detail	Gram positive bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Peptidoglycan	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	Q9NHB0.fasta	Q9NHB0	494	NA	NA	29229443	2017	Pubchem_assay
PRRID_1937	b-1,3-glucan and lipopolysaccharide Click for more detail	Gram positive bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Peptidoglycan	Natural	NA	DmGNBP1	Gram-negative Bacteria-binding Protein (GNBPs)	Drosophila melanogaster	membrane localised	NA	Q9NHB0.fasta	Q9NHB0	494	NA	NA	29229443	2017	Pubchem_assay
PRRID_2083	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	rPtCTL-2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28916358	2017	NA
PRRID_2083	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	rPtCTL-2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28916358	2017	NA
PRRID_2278	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	rPtCTL-2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28288910	2017	NA
PRRID_2278	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	rPtCTL-2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	28288910	2017	NA
PRRID_2280	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	elicit innate immune response	rMrLec	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	27818342	2017	NA
PRRID_2280	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	elicit innate immune response	rMrLec	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	27818342	2017	NA
PRRID_2282	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	elicit innate immune response	MrCTL	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	27620819	2017	NA
PRRID_2282	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	elicit innate immune response	MrCTL	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	27620819	2017	NA
PRRID_2284	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	NA	PcFBN1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	27417229	2017	NA
PRRID_2284	Peptidoglycan (PGN) Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Peptidoglycan	Natural	NA	PcFBN1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	27417229	2017	NA
PRRID_2302	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgPGRPS2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28042081	2017	NA
PRRID_2302	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	rCgPGRPS2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	28042081	2017	NA
PRRID_2315	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2315	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2318	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2318	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2321	M-Tri-DAP Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptidoglycan	Synthetic	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor C2 (NLRC2)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	NA	NA	NA	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	NA
PRRID_2321	M-Tri-DAP Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N	NA	Peptidoglycan	Synthetic	Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-Œ∫B-mediated expression of inflammatory cytokines	Nod-like receptor C2 (NLRC2)	NOD-like receptor (NLR)	Human	Intracellular	C-terminal leucine-rich regions and NOD domains	NA	NA	NA	triggering production of Œ≤-defensins via an NF-Œ∫B signaling pathway	NA	28776416	2017	NA
PRRID_2349	muramyl di- , glycosaminyl muramyl dipeptide Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptidoglycan	Synthetic	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	29207344	2017	NA
PRRID_2349	muramyl di- , glycosaminyl muramyl dipeptide Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptidoglycan	Synthetic	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	29207344	2017	NA
PRRID_2352	Muropeptides Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	29207344	2017	NA
PRRID_2352	Muropeptides Click for more detail	Gram negative Bacteria (Bacteria)	NA	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	29207344	2017	NA
PRRID_2354	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2354	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2539	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	AmphiCTL1	C type Lectin (CTL/CLR)	B. belcheri	NA	NA	NA	NA	NA	NA	NA	29055189	2017	NA
PRRID_2539	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	AmphiCTL1	C type Lectin (CTL/CLR)	B. belcheri	NA	NA	NA	NA	NA	NA	NA	29055189	2017	NA

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