Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1283Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalfunctions as a critical innate sensor for flagellated bacteria in all mucous organsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MiceNeutrophilscell surfaceQ9JLF7.fastaQ9JLF7859important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infectionELISA247782362014Pubchem_assay
PRRID_1283Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalfunctions as a critical innate sensor for flagellated bacteria in all mucous organsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)MiceNeutrophilscell surfaceQ9JLF7.fastaQ9JLF7859important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infectionELISA247782362014Pubchem_assay
PRRID_1284Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCscell surfaceQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247718542014Pubchem_assay
PRRID_1284Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCscell surfaceQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247718542014Pubchem_assay
PRRID_1285Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCscell surfaceO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247718542014Pubchem_assay
PRRID_1285Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCscell surfaceO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247718542014Pubchem_assay
PRRID_1286Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCscell surfaceQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247713282014Pubchem_assay
PRRID_1286Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCscell surfaceQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247713282014Pubchem_assay
PRRID_1287Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCscell surfaceO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247713282014Pubchem_assay
PRRID_1287Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCscell surfaceO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.ELISA247713282014Pubchem_assay
PRRID_1288Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCsCell Surface (Exogenous)Q9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.whole blood assay (WBA), ELISA247668202014Pubchem_assay
PRRID_1288Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCsCell Surface (Exogenous)Q9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.whole blood assay (WBA), ELISA247668202014Pubchem_assay
PRRID_1289Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCsCell Surface (Exogenous)O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.whole blood assay (WBA), ELISA247668202014Pubchem_assay
PRRID_1289Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCsCell Surface (Exogenous)O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.whole blood assay (WBA), ELISA247668202014Pubchem_assay
PRRID_1290Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCsextracellular domains of leucine-rich repeat motifsQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA247543202014Pubchem_assay
PRRID_1290Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCsextracellular domains of leucine-rich repeat motifsQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA247543202014Pubchem_assay
PRRID_1291Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCsextracellular domains of leucine-rich repeat motifsO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA247543202014Pubchem_assay
PRRID_1291Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCsextracellular domains of leucine-rich repeat motifsO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA247543202014Pubchem_assay
PRRID_1292Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalinduced significant up-regulation of IL-1b and IL-8Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs NAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.Real-time PCR247362052014Pubchem_assay
PRRID_1292Flagellin

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Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalinduced significant up-regulation of IL-1b and IL-8Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs NAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.Real-time PCR247362052014Pubchem_assay
PRRID_1293Flagellin

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Vibrio anguillarum (Bacteria)MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG377ProteinNaturalFlagellin induced expres- sion of inflammatory cytokines Toll-like receptor 5M (TLR5M)Toll-like receptor (TLR)Atlantic salmon (Salmo salar)muscle, head kidney, liver, gut, heart, spleen and gillNANANANAit could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellinReal-time PCR247362052014NA
PRRID_1293Flagellin

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Vibrio anguillarum (Bacteria)MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG377ProteinNaturalFlagellin induced expres- sion of inflammatory cytokines Toll-like receptor 5M (TLR5M)Toll-like receptor (TLR)Atlantic salmon (Salmo salar)muscle, head kidney, liver, gut, heart, spleen and gillNANANANAit could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellinReal-time PCR247362052014NA
PRRID_1294Flagellin

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Vibrio anguillarum (Bacteria)MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG377ProteinNaturalFlagellin induced expres- sion of inflammatory cytokines Toll-like receptor 5s (TLR5s)Toll-like receptor (TLR)Atlantic salmon (Salmo salar)predominanlty in liverNANANANAit could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellinReal-time PCR247362052014NA
PRRID_1294Flagellin

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Vibrio anguillarum (Bacteria)MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG377ProteinNaturalFlagellin induced expres- sion of inflammatory cytokines Toll-like receptor 5s (TLR5s)Toll-like receptor (TLR)Atlantic salmon (Salmo salar)predominanlty in liverNANANANAit could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellinReal-time PCR247362052014NA
PRRID_1295Flagellin

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Salmonella typhimurium strain 14028 (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalflagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediatorsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocytes and immature dendritic cells, as well as on epithelial cellsNAO60602.fastaO60602858activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activityELISA247090112014Pubchem_assay
PRRID_1295Flagellin

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Salmonella typhimurium strain 14028 (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalflagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediatorsToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocytes and immature dendritic cells, as well as on epithelial cellsNAO60602.fastaO60602858activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activityELISA247090112014Pubchem_assay
PRRID_1329HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAsignificant role in the pathogenesis of severe inflammatory responsesNA248300242014NA
PRRID_1329HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAsignificant role in the pathogenesis of severe inflammatory responsesNA248300242014NA
PRRID_1330HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyteCell Surface (Exogenous)O00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA248300242014Pubchem_assay
PRRID_1330HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyteCell Surface (Exogenous)O00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA248300242014Pubchem_assay
PRRID_1331HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA248300242014Pubchem_assay
PRRID_1331HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micemonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA248300242014Pubchem_assay
PRRID_1332HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice(DCs)Dendritic cellscell surfaceQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA248250612014Pubchem_assay
PRRID_1332HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice(DCs)Dendritic cellscell surfaceQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA248250612014Pubchem_assay
PRRID_1333HMGB1

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pulmonary vascular cells (e.g., endothelial cells) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalreleased in responses to local stresses (hypoxia or inflammation)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human Plateletsmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyteLeucine-rich Repeat (LRR) DomainQ7L0X0.fastaQ7L0X0811TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension)NA248123462014Pubchem_assay
PRRID_1333HMGB1

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pulmonary vascular cells (e.g., endothelial cells) (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalreleased in responses to local stresses (hypoxia or inflammation)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human Plateletsmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyteLeucine-rich Repeat (LRR) DomainQ7L0X0.fastaQ7L0X0811TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension)NA248123462014Pubchem_assay
PRRID_1334HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay a critical role in the pathogenesis of inflammationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Endotoxemic Micemonocyte/macrophagescell surfaceQ9QUK6.fastaQ9QUK6835HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokinesqRT-PCR, immunofluorescence assay, western blot248023902014Pubchem_assay
PRRID_1334HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay a critical role in the pathogenesis of inflammationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Endotoxemic Micemonocyte/macrophagescell surfaceQ9QUK6.fastaQ9QUK6835HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokinesqRT-PCR, immunofluorescence assay, western blot248023902014Pubchem_assay
PRRID_1335HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceKeratinocytes and mouse skincell surfaceQ9QUK6.fastaQ9QUK6835play a role in UVB induced immune suppressionNA247862232014Pubchem_assay
PRRID_1335HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceKeratinocytes and mouse skincell surfaceQ9QUK6.fastaQ9QUK6835play a role in UVB induced immune suppressionNA247862232014Pubchem_assay
PRRID_1336HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytes and mouse skincell surfaceO00206.fastaO00206839play a role in UVB induced immune suppressionNA247862232014Pubchem_assay
PRRID_1336HMGB1

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Human (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytes and mouse skincell surfaceO00206.fastaO00206839play a role in UVB induced immune suppressionNA247862232014Pubchem_assay
PRRID_1337HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalreleased in brain injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceischemic brain tissuecell surfaceQ9QUK6.fastaQ9QUK6835TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenonNA247845862014Pubchem_assay
PRRID_1337HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalreleased in brain injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Miceischemic brain tissuecell surfaceQ9QUK6.fastaQ9QUK6835TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenonNA247845862014Pubchem_assay
PRRID_1338HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalreleased in brain injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanischemic brain tissuecell surfaceO00206.fastaO00206839TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenonNA247845862014Pubchem_assay
PRRID_1338HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalreleased in brain injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanischemic brain tissuecell surfaceO00206.fastaO00206839TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenonNA247845862014Pubchem_assay
PRRID_1339HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)Q9QUK6.fastaQ9QUK6835plays a fundamental role in pathogen recognition and activation of innate immunityNA247543202014Pubchem_assay
PRRID_1339HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)Q9QUK6.fastaQ9QUK6835plays a fundamental role in pathogen recognition and activation of innate immunityNA247543202014Pubchem_assay
PRRID_1340HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA247543202014Pubchem_assay
PRRID_1340HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA247543202014Pubchem_assay
PRRID_1341HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceQ9QUN7.fastaQ9QUN7784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1341HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceQ9QUN7.fastaQ9QUN7784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1342HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceO60603.fastaO60603784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1342HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellscell surfaceO60603.fastaO60603784Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemiaNA248071662014Pubchem_assay
PRRID_1343HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytecell surfaceQ9QUK6.fastaQ9QUK6835Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1343HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytecell surfaceQ9QUK6.fastaQ9QUK6835Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1344HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytecell surfaceO00206.fastaO00206839Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1344HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytecell surfaceO00206.fastaO00206839Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemiaNA248071662014Pubchem_assay
PRRID_1381internalized flagellin

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Salmonella typhimurium or Legionella pneumophila (Bacteria)KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL76ProteinNaturalFlagellin and LPS stimulate the production of CXCL1 and CXCL2Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)Micemedullary collecting duct (MCD) cellsintracellular receptorsQ3UP24.fastaQ3UP241024assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18ELISA, adhesion and invasion assay247794332014Pubchem_assay
PRRID_1381internalized flagellin

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Salmonella typhimurium or Legionella pneumophila (Bacteria)KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL76ProteinNaturalFlagellin and LPS stimulate the production of CXCL1 and CXCL2Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)Micemedullary collecting duct (MCD) cellsintracellular receptorsQ3UP24.fastaQ3UP241024assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18ELISA, adhesion and invasion assay247794332014Pubchem_assay
PRRID_1382internalized flagellin

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Salmonella typhimurium or Legionella pneumophila (Bacteria)KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL76ProteinNaturalFlagellin and LPS stimulate the production of CXCL1 and CXCL2Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)Humanmedullary collecting duct (MCD) cellsintracellular receptorsQ9NPP4.fastaQ9NPP41024assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18ELISA, adhesion and invasion assay247794332014Pubchem_assay
PRRID_1382internalized flagellin

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Salmonella typhimurium or Legionella pneumophila (Bacteria)KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL76ProteinNaturalFlagellin and LPS stimulate the production of CXCL1 and CXCL2Nod-like receptor C4 (NLRC4)NOD-like receptor (NLR)Humanmedullary collecting duct (MCD) cellsintracellular receptorsQ9NPP4.fastaQ9NPP41024assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18ELISA, adhesion and invasion assay247794332014Pubchem_assay
PRRID_1463LRR

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BacteriaNANAProteinNaturalNAJNKBP1Pattern recognition receptor (PRR)NANANANANANANANA255201852014NA
PRRID_1463LRR

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BacteriaNANAProteinNaturalNAJNKBP1Pattern recognition receptor (PRR)NANANANANANANANA255201852014NA
PRRID_1466GLU

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNArAi- FREP-2Pattern recognition receptor (PRR)NANANANANANANANA246806672014NA
PRRID_1466GLU

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Gram-negative and Gram-positive bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNArAi- FREP-2Pattern recognition receptor (PRR)NANANANANANANANA246806672014NA
PRRID_1470N-Acetyl-D-mannosamine

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNAERGIC-53Pattern recognition receptor (PRR)NANANANANANANANA247968682014NA
PRRID_1470N-Acetyl-D-mannosamine

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNAERGIC-53Pattern recognition receptor (PRR)NANANANANANANANA247968682014NA
PRRID_1472LRR

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BacteriaNANAProteinNaturalNADUOX2NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1472LRR

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BacteriaNANAProteinNaturalNADUOX2NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1473LRR

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BacteriaNANAProteinNaturalNAFRMPD2NOD-like receptor (NLR)NAstabilizes NOD2, required for NF-kB signallingNANANANANANA255201852014NA
PRRID_1473LRR

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BacteriaNANAProteinNaturalNAFRMPD2NOD-like receptor (NLR)NAstabilizes NOD2, required for NF-kB signallingNANANANANANA255201852014NA
PRRID_1504NACHT

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BacteriaNANAProteinNaturalNACARD8NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1504NACHT

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BacteriaNANAProteinNaturalNACARD8NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1505NACHT

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BacteriaNANAProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1505NACHT

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BacteriaNANAProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1506NACHT

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BacteriaNANAProteinNaturalNATRIM27NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1506NACHT

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BacteriaNANAProteinNaturalNATRIM27NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1507NACHT-LRR

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BacteriaNANAProteinNaturalNAMAVSNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1507NACHT-LRR

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BacteriaNANAProteinNaturalNAMAVSNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1508NACHT-LRR

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VirusNANAProteinNaturalNANIKNOD-like receptor (NLR)NAantiviral defenceNANANANANANA255201852014NA
PRRID_1508NACHT-LRR

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VirusNANAProteinNaturalNANIKNOD-like receptor (NLR)NAantiviral defenceNANANANANANA255201852014NA
PRRID_1511Acetyl-D-mannosamine

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNAVIP36Pattern recognition receptor (PRR)NANANANANANANANA247968682014NA
PRRID_1511Acetyl-D-mannosamine

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAProteinNaturalNAVIP36Pattern recognition receptor (PRR)NANANANANANANANA247968682014NA
PRRID_1512NACHT

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BacteriaNANAProteinNaturalNAAAMPNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1512NACHT

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BacteriaNANAProteinNaturalNAAAMPNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1534PAMPS

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Pathogens (others)NANAProteinNaturalNAMcC1qDCPattern recognition receptor (PRR)NANANANANANANANA242964352014NA
PRRID_1534PAMPS

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Pathogens (others)NANAProteinNaturalNAMcC1qDCPattern recognition receptor (PRR)NANANANANANANANA242964352014NA
PRRID_1563CARDs

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BacteriaNANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1563CARDs

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BacteriaNANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1592profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagesCell Surface (Exogenous)Q6R5P0.fastaQ6R5P0926induces the release of interleukin 12 against T. gondii infected miceNA248300242014Pubchem_assay
PRRID_1592profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagesCell Surface (Exogenous)Q6R5P0.fastaQ6R5P0926induces the release of interleukin 12 against T. gondii infected miceNA248300242014Pubchem_assay
PRRID_1593profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagescell compartmentQ6R5P0.fastaQ6R5P0926induces the release of interleukin 12 against T. gondii infected miceNA248071662014Pubchem_assay
PRRID_1593profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micemonocyte/macrophagescell compartmentQ6R5P0.fastaQ6R5P0926induces the release of interleukin 12 against T. gondii infected miceNA248071662014Pubchem_assay
PRRID_1594proteoglycolipid complex (P8)

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Leishmania (others)NANAProteinNaturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)TLR-deficient Mice on a C57BL/6monocyte/macrophagescell surfaceQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA248017352014Pubchem_assay
PRRID_1594proteoglycolipid complex (P8)

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Leishmania (others)NANAProteinNaturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)TLR-deficient Mice on a C57BL/6monocyte/macrophagescell surfaceQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA248017352014Pubchem_assay
PRRID_1600Recombinant IFNβ

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CHO cells(others)MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNCQCQKLLWQLNGRLEYCLKDRRNFDIPEEIKQLQQFQKEDAAVTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQRNHLKTVLEEKLEKEDFTRGKRMSSLHLKRYYGRILHYLKAKEDSHCAWTIVRVEILRNFYVINRLTGYLRN187ProteinSyntheticplay an important role in inducing non-specific resistance against a broad range of viral infections.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humannasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individualsendosomal receptorO15455.fastaO15455904TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsELISA and Immunofluoroscence assay248303842014Pubchem_assay
PRRID_1600Recombinant IFNβ

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CHO cells(others)MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNCQCQKLLWQLNGRLEYCLKDRRNFDIPEEIKQLQQFQKEDAAVTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQRNHLKTVLEEKLEKEDFTRGKRMSSLHLKRYYGRILHYLKAKEDSHCAWTIVRVEILRNFYVINRLTGYLRN187ProteinSyntheticplay an important role in inducing non-specific resistance against a broad range of viral infections.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Humannasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individualsendosomal receptorO15455.fastaO15455904TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsELISA and Immunofluoroscence assay248303842014Pubchem_assay
PRRID_1610S100A12

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BacteriaMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92ProteinNaturalNASoluble RAGE (sRAGE)Receptor for advanced glycation endproducts (RAGE)NANANANANANANANA251830172014NA
PRRID_1610S100A12

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BacteriaMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92ProteinNaturalNASoluble RAGE (sRAGE)Receptor for advanced glycation endproducts (RAGE)NANANANANANANANA251830172014NA