Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1283 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | functions as a critical innate sensor for flagellated bacteria in all mucous organs | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Neutrophils | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection | ELISA | 24778236 | 2014 | Pubchem_assay |
| PRRID_1283 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | functions as a critical innate sensor for flagellated bacteria in all mucous organs | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Neutrophils | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection | ELISA | 24778236 | 2014 | Pubchem_assay |
| PRRID_1284 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1284 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1285 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | cell surface | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1285 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | cell surface | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1286 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1286 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1287 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | cell surface | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1287 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | cell surface | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1288 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1288 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1289 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | Cell Surface (Exogenous) | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1289 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | Cell Surface (Exogenous) | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1290 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1290 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1291 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1291 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1292 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced significant up-regulation of IL-1b and IL-8 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1292 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced significant up-regulation of IL-1b and IL-8 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | Real-time PCR | 24736205 | 2014 | Pubchem_assay |
| PRRID_1293 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5M (TLR5M) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1293 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5M (TLR5M) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1294 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5s (TLR5s) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | predominanlty in liver | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1294 | Flagellin Click for more detail | Vibrio anguillarum (Bacteria) | MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG | 377 | Protein | Natural | Flagellin induced expres- sion of inflammatory cytokines | Toll-like receptor 5s (TLR5s) | Toll-like receptor (TLR) | Atlantic salmon (Salmo salar) | predominanlty in liver | NA | NA | NA | NA | it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin | Real-time PCR | 24736205 | 2014 | NA |
| PRRID_1295 | Flagellin Click for more detail | Salmonella typhimurium strain 14028 (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes and immature dendritic cells, as well as on epithelial cells | NA | O60602.fasta | O60602 | 858 | activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity | ELISA | 24709011 | 2014 | Pubchem_assay |
| PRRID_1295 | Flagellin Click for more detail | Salmonella typhimurium strain 14028 (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes and immature dendritic cells, as well as on epithelial cells | NA | O60602.fasta | O60602 | 858 | activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity | ELISA | 24709011 | 2014 | Pubchem_assay |
| PRRID_1329 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 24830024 | 2014 | NA |
| PRRID_1329 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 24830024 | 2014 | NA |
| PRRID_1330 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1330 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1331 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1331 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1332 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1332 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1333 | HMGB1 Click for more detail | pulmonary vascular cells (e.g., endothelial cells) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human Platelets | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Leucine-rich Repeat (LRR) Domain | Q7L0X0.fasta | Q7L0X0 | 811 | TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension) | NA | 24812346 | 2014 | Pubchem_assay |
| PRRID_1333 | HMGB1 Click for more detail | pulmonary vascular cells (e.g., endothelial cells) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human Platelets | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Leucine-rich Repeat (LRR) Domain | Q7L0X0.fasta | Q7L0X0 | 811 | TLR4 is expressed on platelets which mediates inflammatory and immune responses in a variety of diseases including PAH (pulmonary arterial hypertension) | NA | 24812346 | 2014 | Pubchem_assay |
| PRRID_1334 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play a critical role in the pathogenesis of inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemic Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokines | qRT-PCR, immunofluorescence assay, western blot | 24802390 | 2014 | Pubchem_assay |
| PRRID_1334 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play a critical role in the pathogenesis of inflammation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemic Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokines | qRT-PCR, immunofluorescence assay, western blot | 24802390 | 2014 | Pubchem_assay |
| PRRID_1335 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1335 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1336 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes and mouse skin | cell surface | O00206.fasta | O00206 | 839 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1336 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes and mouse skin | cell surface | O00206.fasta | O00206 | 839 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1337 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1337 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1338 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | ischemic brain tissue | cell surface | O00206.fasta | O00206 | 839 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1338 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | ischemic brain tissue | cell surface | O00206.fasta | O00206 | 839 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1339 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1339 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1340 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1340 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1341 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1341 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1342 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | O60603.fasta | O60603 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1342 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | O60603.fasta | O60603 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1343 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1343 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1344 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1344 | HMGB1 Click for more detail | NA | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1381 | internalized flagellin Click for more detail | Salmonella typhimurium or Legionella pneumophila (Bacteria) | KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL | 76 | Protein | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | medullary collecting duct (MCD) cells | intracellular receptors | Q3UP24.fasta | Q3UP24 | 1024 | assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18 | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1381 | internalized flagellin Click for more detail | Salmonella typhimurium or Legionella pneumophila (Bacteria) | KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL | 76 | Protein | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | medullary collecting duct (MCD) cells | intracellular receptors | Q3UP24.fasta | Q3UP24 | 1024 | assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18 | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1382 | internalized flagellin Click for more detail | Salmonella typhimurium or Legionella pneumophila (Bacteria) | KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL | 76 | Protein | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Human | medullary collecting duct (MCD) cells | intracellular receptors | Q9NPP4.fasta | Q9NPP4 | 1024 | assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18 | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1382 | internalized flagellin Click for more detail | Salmonella typhimurium or Legionella pneumophila (Bacteria) | KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL | 76 | Protein | Natural | Flagellin and LPS stimulate the production of CXCL1 and CXCL2 | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Human | medullary collecting duct (MCD) cells | intracellular receptors | Q9NPP4.fasta | Q9NPP4 | 1024 | assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18 | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1463 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | JNKBP1 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1463 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | JNKBP1 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1466 | GLU Click for more detail | Gram-negative and Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | rAi- FREP-2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24680667 | 2014 | NA |
| PRRID_1466 | GLU Click for more detail | Gram-negative and Gram-positive bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | rAi- FREP-2 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24680667 | 2014 | NA |
| PRRID_1470 | N-Acetyl-D-mannosamine Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | ERGIC-53 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1470 | N-Acetyl-D-mannosamine Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | ERGIC-53 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1472 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | DUOX2 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1472 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | DUOX2 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1473 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | FRMPD2 | NOD-like receptor (NLR) | NA | stabilizes NOD2, required for NF-kB signalling | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1473 | LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | FRMPD2 | NOD-like receptor (NLR) | NA | stabilizes NOD2, required for NF-kB signalling | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1504 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | CARD8 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1504 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | CARD8 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1505 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1505 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1506 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | TRIM27 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1506 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | TRIM27 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1507 | NACHT-LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | MAVS | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1507 | NACHT-LRR Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | MAVS | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1508 | NACHT-LRR Click for more detail | Virus | NA | NA | Protein | Natural | NA | NIK | NOD-like receptor (NLR) | NA | antiviral defence | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1508 | NACHT-LRR Click for more detail | Virus | NA | NA | Protein | Natural | NA | NIK | NOD-like receptor (NLR) | NA | antiviral defence | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1511 | Acetyl-D-mannosamine Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | VIP36 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1511 | Acetyl-D-mannosamine Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Protein | Natural | NA | VIP36 | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24796868 | 2014 | NA |
| PRRID_1512 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | AAMP | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1512 | NACHT Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | AAMP | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1534 | PAMPS Click for more detail | Pathogens (others) | NA | NA | Protein | Natural | NA | McC1qDC | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24296435 | 2014 | NA |
| PRRID_1534 | PAMPS Click for more detail | Pathogens (others) | NA | NA | Protein | Natural | NA | McC1qDC | Pattern recognition receptor (PRR) | NA | NA | NA | NA | NA | NA | NA | NA | 24296435 | 2014 | NA |
| PRRID_1563 | CARDs Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1563 | CARDs Click for more detail | Bacteria | NA | NA | Protein | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 25520185 | 2014 | NA |
| PRRID_1592 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 | induces the release of interleukin 12 against T. gondii infected mice | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1592 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 | induces the release of interleukin 12 against T. gondii infected mice | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1593 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell compartment | Q6R5P0.fasta | Q6R5P0 | 926 | induces the release of interleukin 12 against T. gondii infected mice | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1593 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell compartment | Q6R5P0.fasta | Q6R5P0 | 926 | induces the release of interleukin 12 against T. gondii infected mice | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1594 | proteoglycolipid complex (P8) Click for more detail | Leishmania (others) | NA | NA | Protein | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1594 | proteoglycolipid complex (P8) Click for more detail | Leishmania (others) | NA | NA | Protein | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1600 | Recombinant IFNβ Click for more detail | CHO cells(others) | MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNCQCQKLLWQLNGRLEYCLKDRRNFDIPEEIKQLQQFQKEDAAVTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQRNHLKTVLEEKLEKEDFTRGKRMSSLHLKRYYGRILHYLKAKEDSHCAWTIVRVEILRNFYVINRLTGYLRN | 187 | Protein | Synthetic | play an important role in inducing non-specific resistance against a broad range of viral infections. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals | endosomal receptor | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | ELISA and Immunofluoroscence assay | 24830384 | 2014 | Pubchem_assay |
| PRRID_1600 | Recombinant IFNβ Click for more detail | CHO cells(others) | MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNCQCQKLLWQLNGRLEYCLKDRRNFDIPEEIKQLQQFQKEDAAVTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQRNHLKTVLEEKLEKEDFTRGKRMSSLHLKRYYGRILHYLKAKEDSHCAWTIVRVEILRNFYVINRLTGYLRN | 187 | Protein | Synthetic | play an important role in inducing non-specific resistance against a broad range of viral infections. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals | endosomal receptor | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | ELISA and Immunofluoroscence assay | 24830384 | 2014 | Pubchem_assay |
| PRRID_1610 | S100A12 Click for more detail | Bacteria | MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE | 92 | Protein | Natural | NA | Soluble RAGE (sRAGE) | Receptor for advanced glycation endproducts (RAGE) | NA | NA | NA | NA | NA | NA | NA | NA | 25183017 | 2014 | NA |
| PRRID_1610 | S100A12 Click for more detail | Bacteria | MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE | 92 | Protein | Natural | NA | Soluble RAGE (sRAGE) | Receptor for advanced glycation endproducts (RAGE) | NA | NA | NA | NA | NA | NA | NA | NA | 25183017 | 2014 | NA |