Detailed description page of PRRDB2.0

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PRRID_1341 details
Primary information
PRRIDPRRID_1341
Ligand NameHMGB1
SourceEndogenous (others)
Sequence of ligandMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE
Length215
TypeProtein
OccurenceNatural
Role of LigandHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Domaincell surface
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
FunctionPossible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
Assay usedNA
PMID24807166
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1341
Ligand NameHMGB1
SourceEndogenous (others)
Sequence of ligandMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE
Length215
TypeProtein
OccurenceNatural
Role of LigandHMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Domaincell surface
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
FunctionPossible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia
Assay usedNA
PMID24807166
Year of Publication2014
Pubchem assayPubchem_assay