Detailed description page of PRRDB2.0

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PRRID_1382 details
Primary information
PRRIDPRRID_1382
Ligand Nameinternalized flagellin
SourceSalmonella typhimurium or Legionella pneumophila (Bacteria)
Sequence of ligandKLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL
Length76
TypeProtein
OccurenceNatural
Role of LigandFlagellin and LPS stimulate the production of CXCL1 and CXCL2
Name of receptorNod-like receptor C4 (NLRC4)
Type of receptorNOD-like receptor (NLR)
Source Human
Localizationmedullary collecting duct (MCD) cells
Domainintracellular receptors
Sequence of ReceptorQ9NPP4.fasta
Swiss prot IDQ9NPP4
Length Of Receptor1024
Functionassemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18
Assay usedELISA, adhesion and invasion assay
PMID24779433
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1382
Ligand Nameinternalized flagellin
SourceSalmonella typhimurium or Legionella pneumophila (Bacteria)
Sequence of ligandKLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL
Length76
TypeProtein
OccurenceNatural
Role of LigandFlagellin and LPS stimulate the production of CXCL1 and CXCL2
Name of receptorNod-like receptor C4 (NLRC4)
Type of receptorNOD-like receptor (NLR)
Source Human
Localizationmedullary collecting duct (MCD) cells
Domainintracellular receptors
Sequence of ReceptorQ9NPP4.fasta
Swiss prot IDQ9NPP4
Length Of Receptor1024
Functionassemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1β and IL-18
Assay usedELISA, adhesion and invasion assay
PMID24779433
Year of Publication2014
Pubchem assayPubchem_assay